Patents by Inventor Helle Naver

Helle Naver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivative of an insulin analogue
    Patent number: 9896496
    Abstract: The present invention provides a novel derivative of an analogue of human insulin, useful for the treatment of diabetes.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: February 20, 2018
    Assignee: Novo Nordisk A/S
    Inventors: Peter Madsen, Tina Moeller Tagmose, Helle Naver, Thomas Boerglum Kjeldsen
  • Insulin formulations
    Patent number: 9481721
    Abstract: A stable pharmaceutical formulation containing an insulin derivative can conveniently be prepared by adding glycerol, phenol, m-cresol and zinc ions to it.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: November 1, 2016
    Assignee: Novo Nordisk A/S
    Inventors: Helle Naver, Morten Schlein, Dorte Bjerre Steensgaard, Ingrid Vivika Petterson
  • NOVEL DERIVATIVE OF AN INSULIN ANALOGUE
    Publication number: 20160215037
    Abstract: The present invention provides a novel derivative of an analogue of human insulin, useful for the treatment of diabetes.
    Type: Application
    Filed: October 3, 2014
    Publication date: July 28, 2016
    Inventors: Peter Madsen, Tina Moeller Tagmose, Helle Naver, Thomas Boerglum Kjeldsen
  • Preparation Comprising Insulin, Nicotinamide and an Amino Acid
    Publication number: 20150182595
    Abstract: Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
    Type: Application
    Filed: March 16, 2015
    Publication date: July 2, 2015
    Inventors: Helle Birk Olsen, Svend Havelund, Ulla Ribel-Madsen, Jeppe Sturis, Helle Naver, Morten Schlein, Svend Ludvigsen
  • INSULIN FORMULATIONS
    Publication number: 20150126442
    Abstract: A stable pharmaceutical formulation containing an insulin derivative can conveniently be prepared by adding glycerol, phenol, m-cresol and zinc ions to it.
    Type: Application
    Filed: April 5, 2013
    Publication date: May 7, 2015
    Applicant: NOVO NORDISK A/S
    Inventors: Helle Naver, Morten Schlein, Dorte Bjerre Steensgaard, Ingrid Vivika Petterson
  • NOVEL USE OF INSULIN DERIVATIVES
    Publication number: 20150111820
    Abstract: This invention relates to insulin derivatives having long duration of action. The insulin derivatives have been found to be useful for the treatment of diabetes, and in particular for less frequent administration to the diabetic patients, in particular as seldom as about once weekly.
    Type: Application
    Filed: July 8, 2013
    Publication date: April 23, 2015
    Inventors: Lone Pridal, Helle Naver, Peter Madsen, Thomas Boerglum Kjeldsen
  • STABLE NON-AQUEOUS LIQUID PHARMACEUTICAL COMPOSITIONS COMPRISING AN INSULIN
    Publication number: 20140329744
    Abstract: The invention describes a non-aqueous liquid pharmaceutical composition comprising at least one lipid and at least one insulin. Also described is a method of producing a pharmaceutical composition comprising a lipid and a method of purifying a lipid, a cosolvent, a surfactant or a pharmaceutical composition comprising a lipid.
    Type: Application
    Filed: July 17, 2014
    Publication date: November 6, 2014
    Inventors: Helle Naver, Florian A. Foeger, Thomas Hoeg-Jensen, Charlotte H. Fynbo
  • Pharmaceutical solution of non covalently bound albumin and acylated insulin
    Patent number: 8865647
    Abstract: If albumin is added to a pharmaceutical formulation containing acylated insulin described in WO 2009/022005 and WO 2009/022013, the acylated insulin can be kept in solution after subcutaneous injection.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: October 21, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Helle Naver, Svend Havelund, Peter Madsen
  • Preparation Comprising Insulin, Nicotinamide and an Amino Acid
    Publication number: 20140206610
    Abstract: Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
    Type: Application
    Filed: March 24, 2014
    Publication date: July 24, 2014
    Applicant: Novo Nordisk A/S
    Inventors: Helle Birk Olsen, Svend Havelund, Ulla Ribel-Madsen, Jeppe Sturis, Helle Naver, Morten Schlein, Svend Ludvigsen
  • Preparation comprising insulin, nicotinamide and an amino acid
    Patent number: 8324157
    Abstract: Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: December 4, 2012
    Assignee: Novo Nordisk A/S
    Inventors: Helle Birk Olsen, Svend Havelund, Ulla Ribel-Madsen, Jeppe Sturis, Helle Naver, Morten Schlein, Svend Ludvigsen
  • Pharmaceutical Solution of Non Covalently Bound Albumin and Acylated Insulin
    Publication number: 20120245085
    Abstract: If albumin is added to a pharmaceutical formulation containing acylated insulin described in WO 2009/022005 and WO 2009/022013, the acylated insulin can be kept in solution after subcutaneous injection.
    Type: Application
    Filed: November 1, 2010
    Publication date: September 27, 2012
    Applicant: Novo Nordisk A/S
    Inventors: Helle Naver, Svend Havelund, Peter Madsen
  • STABLE NON-AQUEOUS LIQUID PHARMACEUTICAL COMPOSITIONS COMPRISING AN INSULIN
    Publication number: 20120196800
    Abstract: The invention describes a non-aqueous liquid pharmaceutical composition comprising at least one lipid and at least one insulin. Also described is a method of producing a pharmaceutical composition comprising a lipid and a method of purifying a lipid, a cosolvent, a surfactant or a pharmaceutical composition comprising a lipid.
    Type: Application
    Filed: September 16, 2010
    Publication date: August 2, 2012
    Applicant: Novo Nordisk A/S
    Inventors: Helle Naver, Florian Anders Föger, Thomas Hoeg-Jensen, Charlotte Harkjaer Fynbo
  • Preparation Comprising Insulin, Nicotinamide and an Amino Acid
    Publication number: 20120135920
    Abstract: Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
    Type: Application
    Filed: December 1, 2011
    Publication date: May 31, 2012
    Applicant: Novo Nordisk A/S
    Inventors: Helle Birk Olsen, Svend Havelund, Ulla Ribel-Madsen, Jeppe Sturis, Helle Naver, Morten Schlein, Svend Ludvigsen
  • Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
    Publication number: 20110009314
    Abstract: The present invention is related to fast acting single-chain insulin comprising a modified B-chain and the A-chain of human insulin or an analogue thereof connected by a connecting peptide wherein one or more of the amino acid residues in position B25, B26 or B27 in the human B-chain are Glu or Asp or are deleted and/or B28 is Glu, Asp, Lys or is deleted, and the amino acid residue in position B10 in the human insulin B-chain is Gln, Ala, Val, Thr or Ser. The invention is also related to pharmaceutical compositions being a mixture of the rapid acting single-chain insulin and the protracted acylated insulin.
    Type: Application
    Filed: September 17, 2010
    Publication date: January 13, 2011
    Applicant: Novo Nordisk A/S
    Inventors: Helle Naver, Thomas Børglum Kjeldsen
  • Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
    Publication number: 20090069216
    Abstract: The present invention is related to fast acting single-chain insulin comprising a modified B-chain and the A-chain of human insulin or an analogue thereof connected by a connecting peptide wherein one or more of the amino acid residues in position B25, B26 or B27 in the human B-chain are Glu or Asp or are deleted and/or B28 is Glu, Asp, Lys or is deleted, and the amino acid residue in position B10 in the human insulin B-chain is Gln, Ala, Val, Thr or Ser. The invention is also related to pharmaceutical compositions being a mixture of the rapid acting single-chain insulin and the protracted acylated insulin.
    Type: Application
    Filed: February 19, 2007
    Publication date: March 12, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Helle Naver, Thomas Borglum Kjeldsen