Patents by Inventor Helle Woldike

Helle Woldike has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of Proteins in E. Coli
    Publication number: 20100041153
    Abstract: Plasmid comprising a DNA tag encoding a peptide tag of the sequence MX1(X 2X 3) n X 1 represents K or R; X 2 represents M, S or T; X 3 represents K or R; n represents an integer of 1 or larger; and wherein said DNA is operably-linked to a promoter sequence are provided.
    Type: Application
    Filed: February 22, 2008
    Publication date: February 18, 2010
    Applicant: NOVO NORDISK HEALTHCARE AG
    Inventors: Helle Woldike, Christine Bruun Schiodt
  • IL-21 Derivatives and Variants
    Publication number: 20090253864
    Abstract: The invention provides derivatives of IL-21 or variants thereof, methods of producing such variants, new variants of IL-21, and various methods of using such molecules.
    Type: Application
    Filed: August 12, 2008
    Publication date: October 8, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Bernd Peschke, Christine Bruun Schiodt, Helle Woldike, Florencio Zaragoza Dorwald, Anne Worsaae
  • Expression of Proteins in E.Coli
    Publication number: 20090035821
    Abstract: Plasmid comprising a DNA tag encoding a peptide tag of the sequence MX1(X2X3)n wherein X1 represents K, R or H; X2 represents A, G, H, M, S or T; X3 represents K, R, H, A, Q or V; n represents an integer of 1 or larger; and wherein said DNA is operably-linked to a promoter sequence are provided.
    Type: Application
    Filed: August 30, 2006
    Publication date: February 5, 2009
    Applicant: Novo Nordisk A/S
    Inventors: Helle Woldike, Christine Bruun Schiodt
  • IL-21 Derivatives and variants
    Publication number: 20060228331
    Abstract: The invention provides derivatives of IL-21 or variants thereof, methods of producing such variants, new variants of IL-21, and various methods of using such molecules.
    Type: Application
    Filed: April 10, 2006
    Publication date: October 12, 2006
    Applicant: Novo Nordisk A/S
    Inventors: Bernd Peschke, Christine Schiodt, Helle Woldike, Florencio Dorwald, Anne Worsaae
  • Method for the production of FVII
    Publication number: 20020160458
    Abstract: Disclosed is a method for high efficiency release of recombinant proteins in eukaryotic cells and more specifically, for enhancing the secretion of Factor VII by co-expression of kex2 endoprotease with FVII in cells of mammalian origin.
    Type: Application
    Filed: November 13, 2001
    Publication date: October 31, 2002
    Inventors: Helle Woldike, Finn Wiberg, Lars Soegaard Nielsen
  • Process for the production of protein products in aspergillus
    Patent number: 5536661
    Abstract: A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA-sequences encoding functions facilitating gene expression, a suitable marker for selection of transformants, and a DNA-sequence encoding the desired protein product. The process enables industrial production of many different polypeptides and proteins in A. oryzae. Examples of such products are chymosin or prochymosin and other rennets, proteases, lipases and amylases. Also disclosed is an effective promoter for expression of a protein in Aspergillus. A preferred promoter is the TAKA-amylase promoter or functional parts thereof. There is also provided a process for the production of a recombinant Humicola lipase. The recombinant Humicola lipase from A. oryzae differs from the native lipase in having a greater glycosylation and in exhibiting an improved thermostability.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: July 16, 1996
    Assignee: Novo Nordisk A/S
    Inventors: Esper Boel, Tove Christensen, Helle Woldike