Abstract: Organic peptide containing substances with insulin-like activity derived from blood or a blood component of a warm-blooded animal, which comprises the steps of pre-treating the blood or blood component by adjusting the pH thereof to a value of from 2 to 4 or of from 8 to 10, incubating the pre-treated blood at a temperature of from about 15 to about 40.degree. C for a period of at least four hours, cooling the incubated blood to a temperature of less than 10.degree. C, and recovering from the treated blood after neutralization organic peptide substances having a molecular weight of from about 1000 to about 5000, and an insulin-like activity of from about 14 to about 40 .mu.U/mg solid.

Abstract: The invention concerns a process for removing inorganic salts from a liquid medium having a solids content of from about 25 to about 65 mg/ml and containing active organic peptide substances of a molecular weight of from about 500 to about 10,000 and up to 70% by weight inorganic salts based on the solids content of the liquid medium, which comprises the steps of transferring said liquid medium onto a filtration gel layer carried on a perforated centrifuge drum at a liquid medium: gel volume ratio of from about 1:2.5 to about 1:4.5, said filtration gel layer being higher cross-linked and having a particle size of from about 40 to 120 .mu., centrifuging at a centrifugal force of from about 800 to about 1500 g, and collecting the liquid centrifugate containing the active organic peptide substances and a low amount of salt.The substance recovered by the process possesses growth regulating properties and can be recovered from mammalian blood or serum.

Abstract: The invention concerns a novel process for obtaining insulin-like active substances from blood or a blood component of a warm-blooded animal, which comprises the steps of pre-treating the blood or blood component by adjusting the pH thereof to a value of from 2 to 4 or of from 8 to 10, incubating the pre-treated blood at a temperature of from about 15.degree. to about 40.degree. C for a period of at least four hours, cooling the incubated blood to a temperature of less than 10.degree. C, and recovering from the treated blood after neutralization organic peptide substances having a molecular weight of from about 1000 to about 5000, and an insulin-like activity of from about 14 to about 40 .mu.U/mg solid.

Abstract: Novel blood extracts of vertebrata, i.e. animals having a vertebral column, especially warm blooded animals, which blood extracts possess cell respiration stimulating activity and stimulate the growth of cells and to novel processes for the preparation of the said blood extracts.

Abstract: Compositions derived from spleens of vertebrata and process for obtaining the said compositions which are useful for increasing or decreasing the normal rate of tissue growth.