Patents by Inventor Helmer Rasche

Helmer Rasche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7964586
    Abstract: A method for obtaining an extract containing the natural mixture of conjugated equine estrogens in which a mixture of conjugated estrogens obtained by solid-phase extraction from pregnant mares' urine is depleted in phenolic urine contents and in non-conjugated lipophilic compounds selected from the group consisting of non-conjugated flavonoids, non-conjugated isoflavonoids, non-conjugated norisoprenoids, non-conjugated steroids, in particular androstane and pregnane steroids, and comparable non-conjugated compounds.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: June 21, 2011
    Assignee: Abbott Products GmbH
    Inventors: Heinz-Helmer Rasche, Kirsten Wilbrand, Sabine Banschbach
  • Patent number: 7524833
    Abstract: A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorbent cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: April 28, 2009
    Assignee: Solvay Pharmaceuticals GmbH
    Inventors: Juergen Ahnsorge, Ivan Ban, Heinz-Helmer Rasche
  • Publication number: 20070212751
    Abstract: Use of bacterial strains of the species Amycolatopsis mediterranei for microbial transformation of 9?,10?-steroids of formula (I) to their corresponding 11?-hydroxyl analogues, as well as specific strains of that species, a process for transforming 9?,10?-steroids to their corresponding 11?-hydroxyl derivatives using bacterials strains of the species Amycolatopsis mediterranei, and subsequent isolation of the 11?-hydroxyl derivatives from the bacterial culture medium. The resulting 11?-hydroxylated products are useful intermediates for preparing novel steroidal compounds with 9?,10?-confirmation carrying different kinds of substituents in the 11?-position.
    Type: Application
    Filed: January 16, 2007
    Publication date: September 13, 2007
    Applicant: SOLVAY PHARMACEUTICALS GmbH
    Inventors: Josef Messinger, Heinrich-Hubert Thole, Heinz-Helmer Rasche, Michael Schmidt, Juha Hakala
  • Patent number: 7220733
    Abstract: A method of separating cresol from mares' urine by pervaporation using pore-free polymeric silicone membranes in which starting urine solutions containing high-quality and -quantity conjugated estrogens with a reduced or substantially removed cresol content are provided which are advantageously suitable for obtaining natural mixtures of conjugated estrogens from pregnant mares' urine.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: May 22, 2007
    Assignee: Solvay Pharmaceuticals GmbH
    Inventors: Heinz-Helmer Rasche, Kirsten Wilbrand, Kerstin Woltmann
  • Publication number: 20060234994
    Abstract: A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorbent cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.
    Type: Application
    Filed: June 13, 2006
    Publication date: October 19, 2006
    Inventors: Juergen Ahnsorge, Ivan Ban, Heinz-Helmer Rasche
  • Patent number: 7081451
    Abstract: A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogens as active ingredient. The apparatus is suitable for decentralized concentration and stabilization of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorber cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: July 25, 2006
    Assignee: Solvay Pharmaceuticals GmbH
    Inventors: Juergen Ahnsorge, Ivan Ban, Heinz-Helmer Rasche
  • Patent number: 7074325
    Abstract: An apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogens as active ingredient. The apparatus is suitable for decentralized concentration and stabilization of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorber cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: July 11, 2006
    Assignee: Solvay Pharmaceuticals GmbH
    Inventors: Juergen Ahnsorge, Ivan Ban, Heinz-Helmer Rasche
  • Publication number: 20050230303
    Abstract: An apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogens as active ingredient. The apparatus is suitable for decentralized concentration and stabilization of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorber cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.
    Type: Application
    Filed: June 1, 2005
    Publication date: October 20, 2005
    Inventors: Juergen Ahnsorge, Ivan Ban, Heinz-Helmer Rasche
  • Publication number: 20030215953
    Abstract: A method of separating cresol from mares' urine by pervaporation using pore-free polymeric silicone membranes in which starting urine solutions containing high-quality and -quantity conjugated estrogens with a reduced or substantially removed cresol content are provided which are advantageously suitable for obtaining natural mixtures of conjugated estrogens from pregnant mares' urine.
    Type: Application
    Filed: March 28, 2003
    Publication date: November 20, 2003
    Applicant: Solvay Pharmaceuticals GmbH
    Inventors: Heinz-Helmer Rasche, Kirsten Wilbrand, Kerstin Woltmann
  • Publication number: 20030105344
    Abstract: A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogens as active ingredient. The apparatus is suitable for decentralized concentration and stabilization of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorber cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.
    Type: Application
    Filed: April 1, 2002
    Publication date: June 5, 2003
    Applicant: Solvay Pharmaceuticals GmbH.
    Inventors: Juergen Ahnsorge, Ivan Ban, Heinz-Helmer Rasche
  • Patent number: 6300468
    Abstract: A process for producing porous polymer beads in which polymers, preferably polyolefins or polyvinyl chloride, are dissolved in a solvent, preferably halogenated hydrocarbons or alkyl esters, at temperatures close to the boiling point of the solvent. The hot polymer solution is cooled, and the polymer beads formed during the cooling process are separated, washed and dried. The porous polymer beads are useful, for example, as catalyst carriers or as adsorption agents.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: October 9, 2001
    Assignee: Solvay Deutschland GmbH
    Inventors: Karl-Heinz Bretz, Heinz-Helmer Rasche, Helmut Derleth, Philippe Francois
  • Patent number: 5814624
    Abstract: A method for obtaining an extract from urine of pregnant mares containing a natural mixture of conjugated estrogens by solid-phase extraction of the mixture of conjugated estrogens from the urine of pregnant mares on RP silica gel.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: September 29, 1998
    Assignee: Solvay Deutschland GmbH
    Inventors: Ivan Ban, Friederich Borchers, Henning Heinemann, Heinz-Helmer Rasche
  • Patent number: 5723454
    Abstract: A method for obtaining an extract containing the natural mixture of conjugated estrogens from mare urine by solid-phase extraction of the mixture of conjugated estrogens from the urine of pregnant mares on non-ionic semi-polar polymeric adsorber resins.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: March 3, 1998
    Assignee: Sovlay Deutschland GmbH
    Inventors: Ivan Ban, Henning Heinemann, Gerhard Mechtold, Heinz-Helmer Rasche
  • Patent number: 5494696
    Abstract: A partially denatured whey protein product with a protein content of 65-95% by weight relative to the dry matter, a protein denaturization level of 55-80%, and a mean particle size in the range from 30 to 60 .mu.m, in particular 40-50 .mu.m. The product is suitable for use in foods as an additive with an emulsifying action and good organoleptic properties, particularly in cold-prepared emulsions.
    Type: Grant
    Filed: December 1, 1994
    Date of Patent: February 27, 1996
    Assignee: Danmark Protein A/S
    Inventors: Hans H. Holst, Arne Christensen, Kristian Albertsen, Lars D. Jensen, Mads C. Pedersen, Brian Thomsen, Helmer Rasche, Ulrich Hartmann