Patents by Inventor Helmut Adam
Helmut Adam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220378894Abstract: Methods of eliciting and/or modulating immune responses, therapeutic methods, and antigen delivery methods that include the step of administering a protein particle derived from a cell, the protein particle comprising a diphtheria toxin Cross Reacting Material (CRM) amino acid sequence are disclosed. Included are diagnostic methods using the protein particle derived from a cell, the protein particle comprising a diphtheria toxin CRM amino acid sequence. The methods disclosed herein may be useful as an antigen carrier delivery system.Type: ApplicationFiled: September 21, 2020Publication date: December 1, 2022Inventors: Bernd Helmut Adam REHM, Shuxiong CHEN
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Patent number: 10501505Abstract: The present invention relates to polymer particles and uses thereof. In particular the present invention relates to functionalized polymer particles, processes of production and uses thereof in the diagnosis, treatment or prevention of tuberculosis.Type: GrantFiled: February 4, 2015Date of Patent: December 10, 2019Inventors: Bernd Helmut Adam Rehm, Bryce Malcolm Buddle, David Neil Wedlock
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Publication number: 20180015156Abstract: The present invention relates to polymer particles and uses thereof. In particular the present invention relates to functionalised polymer particles, processes of production and uses thereof in eliciting a cell-mediated immune response and in the treatment or prevention of diseases or conditions including those caused by intracellular pathogens.Type: ApplicationFiled: March 8, 2017Publication date: January 18, 2018Inventors: Bernd Helmut Adam REHM, Natalie Anne PARLANE, David Neil WEDLOCK, Bryce Malcolm BUDDLE
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Publication number: 20170008938Abstract: The present invention relates to polymer particles and uses thereof. In particular the present invention relates to functionalised polymer particles, processes of production and uses thereof in the diagnosis, treatment or prevention of tuberculosis.Type: ApplicationFiled: February 4, 2015Publication date: January 12, 2017Inventors: Bernd Helmut Adam REHM, Bryce Malcolm BUDDLE, David Neil WEDLOCK
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Publication number: 20160175419Abstract: The present invention relates to polymer particles and uses thereof. In particular the present invention relates to functionalised polymer particles, processes of production and uses thereof in eliciting a cell-mediated immune response and in the treatment or prevention of diseases or conditions including those caused by intracellular pathogens.Type: ApplicationFiled: October 29, 2015Publication date: June 23, 2016Inventors: Bernd Helmut Adam Rehm, Natalie Anne Parlane, David Neil Wedlock, Bryce Malcolm Buddle
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Publication number: 20160145654Abstract: The present invention relates to polymer particles and uses thereof. The polymer particle may comprise a polymer selected from poly-beta-amino acids, polylactates, polythioesters and polyesters. In particular the present invention relates to functionalised polymer particles, processes of production and uses thereof. The methods, polymer particles and fusion proteins of the present invention have utility in diagnostics, protein production, biocatalyst immobilisation, and drug delivery.Type: ApplicationFiled: October 29, 2015Publication date: May 26, 2016Inventors: Bernd Helmut Adam Rehm, Bjorn Thomas Backstrom
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Publication number: 20140206759Abstract: The invention relates to a method for producing biodegradable, functionalised polymer particles, and to the use of the same as medicament carriers.Type: ApplicationFiled: December 30, 2013Publication date: July 24, 2014Applicant: Polybatics LimitedInventor: Bernd Helmut Adam Rehm
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Patent number: 8559535Abstract: In a relay scheme, a wireless source apparatus, a wireless destination apparatus and a wireless relay apparatus cooperate for handling transmission failures by space/time diverse channels. In the case of the successful direct transmission, reduced or no additional overhead for the relay selection is incurred. Thus, for a good SNR between source and destination, the inventive protocol has similar performance as a standard approach. In the case of a transmission failure e.g., due to small scale fading, a transmission via a different communication path implementing spatial diversity via a selected relay is supported. The device is to only activate the overhearing of signals in case of weak signal quality between sender and receiver. This selection of relay devices is done by demand only. A specific protocol for the reservation of the wireless medium for the entire cooperative communication has been specified.Type: GrantFiled: November 19, 2010Date of Patent: October 15, 2013Assignee: Lakeside Labs GmbHInventors: Helmut Adam, Wilfried Elmenreich, Christian Bettstetter
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Patent number: 8364075Abstract: In a relay scheme, a wireless source apparatus, a wireless destination apparatus and a wireless relay apparatus cooperate for handling transmission failures by space/time diverse channels. In the case of the successful direct transmission, reduced or no additional overhead for the relay selection is incurred. Thus, for a good SNR between source and destination, the inventive protocol has similar performance as a standard approach. In the case of a transmission failure e.g., due to small scale fading, a transmission via different communication paths implementing spatial diversity via a selected relay is supported. The device is to only activate the overhearing of signals in case of weak signal quality between sender and receiver. This selection of relay devices is done of demand only. A specific protocol for the reservation of the wireless medium for the entire cooperative communication has been specified.Type: GrantFiled: November 19, 2010Date of Patent: January 29, 2013Assignee: Lakeside Labs GmbHInventors: Helmut Adam, Wilfried Elmenreich, Christian Bettstetter
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Publication number: 20120201846Abstract: The present invention relates to polymer particles and uses thereof. In particular the present invention relates to functionalised polymer particles, processes of production and uses thereof in eliciting a cell-mediated immune response and in the treatment or prevention of diseases or conditions including those caused by intracellular pathogens.Type: ApplicationFiled: July 29, 2010Publication date: August 9, 2012Inventors: Bernd Helmut Adam Rehm, Natalie Anne Parlane, David Neil Wedlock, Bryce Malcolm Buddle
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Publication number: 20110124284Abstract: In a relay scheme, a wireless source apparatus, a wireless destination apparatus and a wireless relay apparatus cooperate for handling transmission failures by space/time diverse channels. In the case of the successful direct transmission, reduced or no additional overhead for the relay selection is incurred. Thus, for a good SNR between source and destination, the inventive protocol has similar performance as a standard approach. In the case of a transmission failure e.g., due to small scale fading, a transmission via different communication paths implementing spatial diversity via a selected relay is supported. The device is to only activate the overhearing of signals in case of weak signal quality between sender and receiver. This selection of relay devices is done of demand only. A specific protocol for the reservation of the wireless medium for the entire cooperative communication has been specified.Type: ApplicationFiled: November 19, 2010Publication date: May 26, 2011Inventors: Helmut Adam, Wilfried Elmenreich, Christian Bettstetter
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Publication number: 20110122933Abstract: In a relay scheme, a wireless source apparatus, a wireless destination apparatus and a wireless relay apparatus cooperate for handling transmission failures by space/time diverse channels. In the case of the successful direct transmission, reduced or no additional overhead for the relay selection is incurred. Thus, for a good SNR between source and destination, the inventive protocol has similar performance as a standard approach. In the case of a transmission failure e.g., due to small scale fading, a transmission via a different communication path implementing spatial diversity via a selected relay is supported. The device is to only activate the overhearing of signals in case of weak signal quality between sender and receiver. This selection of relay devices is done by demand only. A specific protocol for the reservation of the wireless medium for the entire cooperative communication has been specified.Type: ApplicationFiled: November 19, 2010Publication date: May 26, 2011Inventors: Helmut Adam, Wilfried Elmenreich, Christian Bettstetter
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Publication number: 20110124516Abstract: The present invention relates to polymer particles and uses thereof. The polymer particle may comprise a polymer selected from poly-beta-amino acids, polylactates, polythioesters and polyesters. In particular the present invention relates to functionalised polymer particles, processes of production and uses thereof. The methods, polymer particles and fusion proteins of the present invention have utility in diagnostics, protein production, biocatalyst immobilisation, and drug delivery.Type: ApplicationFiled: September 27, 2006Publication date: May 26, 2011Inventors: Bernd Helmut Adam Rehm, Bjorn Thomas Backstrom
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Publication number: 20100086972Abstract: The invention relates to a method for producing biodegradable, functionalised polymer particles, and to the use of the same as medicament carriers.Type: ApplicationFiled: October 8, 2009Publication date: April 8, 2010Applicant: Massey UniversityInventor: Bernd Helmut Adam Rehm
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Patent number: 7622277Abstract: The invention relates to a method for producing biodegradable, functionalised polymer particles, and to the use of the same as medicament carriers.Type: GrantFiled: August 22, 2003Date of Patent: November 24, 2009Assignee: Massey UniversityInventor: Bernd Helmut Adam Rehm
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Patent number: 5915988Abstract: A contact for engaging a magnet wire in an insulation displacement manner having a magnet wire insulation displacement contact section for engaging the magnet wire, a conductor engaging portion for engaging an electrical conductor that is be interconnected with the magnet wire, and a body portion therebetween where the conductor engaging portion extends from the body portion as a spring member having a contact surface thereupon remote from the body for forming a wiping interconnection with the conductor.Type: GrantFiled: July 24, 1997Date of Patent: June 29, 1999Assignee: The Whitaker CorporationInventors: Helmut Adam Bitsch, Hartmuth Georg Friedrich Ploesser
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Patent number: 4795189Abstract: An impact activated automotive safety system relying upon relative movement between a drive unit and a chassis of an automobile and comprising a plurality of cables attached, at one of their ends, to the chassis on opposite sides, and slung around a rear portion, of the drive unit and respectively attached by their other ends to a plurality of safety features such as, for instance, a collapsible steering column, seatbelt coiling devices, and seat-lifting mechanisms, all of which would be activated substantially simultaneously in case of a frontal collision by forces transmitted to them by the cables.Type: GrantFiled: August 6, 1987Date of Patent: January 3, 1989Assignee: Audi AG.Inventors: Elmar Vollmer, Helmut Adam, Werner Wilhelm
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Patent number: 4703827Abstract: A safety apparatus for removing the steering wheel of an automotive vehicle from a zone of potential impact with the head of a driver, in case of collision, including a substantially unstretchable connecting member between the steering wheel and a part of the vehicle likely to move forwardly relative to the chassis in case of collision and transferring such movement to the steering wheel to withdraw it towards the dashboard. The steering wheel may be mounted on an axially collapsible column.Type: GrantFiled: August 8, 1985Date of Patent: November 3, 1987Assignee: Audi A.G.Inventors: Elmar Vollmer, Jens Hofmann, Helmut Adam
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Patent number: 3985635Abstract: Separator shields are provided between the substrates subject to sputtering and the boundaries between cathodes or between portions of the cathodes exposing different materials to be sputtered by a glow discharge. The shields extend to a few millimeters' spacing from the cathode and are at a potential at or near ground potential within .+-. 50 volts of the potential of the substrates. A common rear and side shield and a common electrical feed-through connection is provided for the cathode structure or cathodes. The substrates may be passed repeatedly through the sputtering zone or, in a circular configuration, can be moved in a circular path, so as to facilitate alloy-type coatings by producing very thin layers in alternation. The shielding reduces masking of one material by another on the cathode by cross-sputtering, thereby maintaining close to constancy the sputtering rates of the different materials for up to several hundred hours of operation.Type: GrantFiled: February 1, 1974Date of Patent: October 12, 1976Assignee: Robert Bosch G.m.b.H.Inventors: Helmut Adam, Hans Lutz, Gert Siegle
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Patent number: 3930975Abstract: Copper is sputtered onto a substrate to make a solder-fast contact layer by carrying out the sputtering in a discharge of a monatomic gas containing 0.5 to 16% of air, nitrogen or oxygen which reduces the conductivity of the copper layer, but makes it resistant to alloying with a solution in solder, to an extent comparable with the results obtained by the provision of intermediate diffusion barrier layers. Best results are obtained in an argon discharge in the presence of an admixture of nitrogen or air between 2 and 4% by volume. The solder-wetting properties are not impaired.Type: GrantFiled: October 10, 1974Date of Patent: January 6, 1976Assignee: Robert Bosch G.m.b.H.Inventors: Gert Siegle, Hans Lutz, Helmut Adam, Erhard Gossl