Abstract: The present invention relates to systems and methods for screening compounds and/or mutant ribosomal proteins in a eukaryotic cell that increase or decrease the translation of a target gene and thereby ameliorate or revert a defective and/or undesired translation of a target gene. Disclosed are compounds and proteins as identified with the methods and systems of the invention, pharmaceutical and cosmetic compositions thereof, their uses for the preparation of a medicament, methods of treatment of a disease or condition or cosmetic condition related to the defective translation of a gene, for example genetic diseases such as Epidermolysis bullosa, as well as diagnostic measures practical for the clinical evaluation of such diseases or conditions. Also, kits are provided which comprise the identified compounds and/or proteins in addition to suitable means for performing the methods of the invention.

Abstract: The present invention relates to systems and methods for screening compounds and/or mutant ribosomal proteins in a eukaryotic cell that increase or decrease the translation of a target gene and thereby ameliorate or revert a defective and/or undesired translation of a target gene. Disclosed are compounds and proteins as identified with the methods and systems of the invention, pharmaceutical and cosmetic compositions thereof, their uses for the preparation of a medicament, methods of treatment of a disease or condition or cosmetic condition related to the defective translation of a gene, for example genetic diseases such as Epidermolysis bullosa, as well as diagnostic measures practical for the clinical evaluation of such diseases or conditions. Also, kits are provided which comprise the identified compounds and/or proteins in addition to suitable means for performing the methods of the invention.

Abstract: An augment device includes a hollow sleeve surrounding a channel extending through the hollow sleeve from a top to a bottom of the hollow sleeve, the hollow sleeve comprising a wall having an inner face and an outer face. The hollow sleeve includes at least one bending joint, the bending joint being configured for compressing the channel. Thereby the hollow sleeve may be compressed under an external force, leading to a decreased circumference and width of the hollow sleeve. This leads to a gap between the perimeter of the augment device and surrounding bone material, breaking any connections, By virtue of this, a much facilitated removal of the augment device can be achieved. Further, an extraction tool includes grippers for engaging and compressing the augment device, and further instruments, particularly a jig, for achieving an effective removal.

Abstract: A remote control module for a self-propelled working device has a terminal data interface for interchanging data with a mobile terminal using a terminal data protocol specific to the terminal type, and a working device data interface for interchanging data with the working device using a working device data protocol specific to the working device type. A processing unit is adapted, when the mobile terminal is coupled to the self-propelled working device, to determine the identity and the type of the terminal and the identity and the type of the working device via the respective data interface or to retrieve them from a data memory, to reciprocally translate the respective data protocols when interchanging data between the terminal and the working device, and to transmit machine control data (MCD) from the terminal to the working device and to transmit machine status data (MSD) from the working device to the terminal.

Abstract: The invention proposes a system for gravimetrically combining individual bulk material components in one or a plurality of transport container(s). The system comprises a plurality of storage containers for storing the bulk material components equipped with one dosing unit each in order to transfer a respective bulk material component into the transport container. Each of the storage containers is associated with a weighing means disposed below each storage container. The transport containers can be moved between the dosing units of the supply containers along a guidance and cooperate with the weighing means.

Abstract: The invention proposes a system for gravimetrically combining individual bulk material components in one or a plurality of transport container(s). The system comprises a plurality of storage containers for storing the bulk material components equipped with one dosing unit each in order to transfer a respective bulk material component into the transport container. Each of the storage containers is associated with a weighing means disposed below each storage container. The transport containers can be moved between the dosing units of the supply containers along a guidance and cooperate with the weighing means.

Abstract: A filter-fan unit has a housing, at least one fan arranged in the housing, and at least one filter connected to the housing. The housing is transferable from a transport/storage position into a position of use, wherein the transport/storage position is significantly smaller than the position of use. The housing is foldable from the transport/storage position into the position of use. The housing has a housing frame and one or more sidewalls connected with one side to the housing frame.

Abstract: The invention relates to a method for the storage of deep-frozen goods in a freezer having a speed-controlled compressor. In accordance with the invention, the compressor is operated in long-term operation and the temperature is lowered in a low-temperature mode to a temperature which is clearly below ?18° C., and is kept substantially constant at this selected temperature with only low temperature fluctuations which are caused by a change in speed of the compressor.

Abstract: A device for conditioning recirculating air in a cleanroom has at least one fan having a housing. A return air conduit is provided through which a first portion of recirculating air is supplied from the cleanroom to the at least one fan. A second portion of the recirculating air is directly supplied to the at least one fan by bypassing the at least one return air conduit.

Abstract: A filter-fan unit has a housing, at least one fan arranged in the housing, and at least one filter connected to the housing. The housing is transferable from a transport/storage position into a position of use, wherein the transport/storage position is significantly smaller than the position of use. The housing is foldable from the transport/storage position into the position of use. The housing has a housing frame and one or more sidewalls connected with one side to the housing frame.

Abstract: The invention relates to a method for the coupled production of two esters by reacting a mixture of aliphatic alcohols with an aliphatic carboxylic acid and then treating the resulting mixture by distillation. During the distillation process, a side flow that is taken from the distillation column that is connected downstream of the esterification reactor is fed back into said esterification reactor. The pure ester compounds are obtained from the bottom of the distillation columns that are connected downstream of the esterification reactor.

Abstract: The present invention relates to the arrangement of a stator and a spare stator. In order to avoid a permanent correction in the length of the driving shaft, the spare stator is connected to the instantaneously operated stator or is configured in a single piece. Upon occurrence of a defined amount of wear, this stator combination is merely reversed through 180° relative to the longitudinal axis or an intermediate tube is inserted so that the spare stator arrives in the rotor region.

Abstract: The invention relates to a method for the storage of deep-frozen goods in a freezer having a speed-controlled compressor. In accordance with the invention, the compressor is operated in long-term operation and the temperature is lowered in a low-temperature mode to a temperature which is clearly below ?18° C., and is kept substantially constant at this selected temperature with only low temperature fluctuations which are caused by a change in speed of the compressor.

Abstract: A device for conditioning recirculating air in a cleanroom has at least one fan having a housing. A return air conduit is provided through which a first portion of recirculating air is supplied from the cleanroom to the at least one fan. A second portion of the recirculating air is directly supplied to the at least one fan by bypassing the at least one return air conduit.

Abstract: The present invention relates to the arrangement of a stator and a spare stator. In order to avoid a permanent correction in the length of the driving shaft, the spare stator is connected to the instantaneously operated stator or is configured in a single piece. Upon occurrence of a defined amount of wear, this stator combination is merely reversed through 180° relative to the longitudinal axis or an intermediate tube is inserted so that the spare stator arrives in the rotor region.

Abstract: The invention relates to a method for the coupled production of two esters by reacting a mixture of aliphatic alcohols with an aliphatic carboxylic acid and then treating the resulting mixture by distillation. During the distillation process, a side flow that is taken from the distillation column that is connected downstream of the esterification reactor is fed back into said esterification reactor. The pure ester compounds are obtained from the bottom of the distillation columns that are connected downstream of the esterification reactor.

Abstract: An equalizer for automatically equalizing a high-frequency power amplifier having a reference carrier generator which generates a reference carrier from a measured input signal of the high-frequency power amplifier, and a first synchronous demodulator while generating an input envelope curve from the measured input signal and from the reference carrier. A second synchronous demodulator which generates an in-phase component of an output envelope curve from the measured output signal of the high-frequency power amplifier and from the reference carrier, as well as a phase shifter which shifts the phase of the reference carrier 90° are also provided. A third synchronous demodulator generates a quadrature component of the output envelope curve from the measured output signal of the high-frequency power amplifier and from the reference carrier that has been shifted 90° in phase.

Abstract: A catalytic converter housing arrangement includes inlet and outlet funnels having large diameter ends mounted by connection bevels at the ends of a wound metal sheet forming a tubular central part of the catalytic converter and welded to the bevels. The funnels are produced from tubular blanks by expanding one end and drawing in the other end. This results in a significant reduction in weight compared with funnels which are deep-drawn from sheet-metal blanks.

Abstract: A blower unit for clean rooms has a housing with a bottom, a cover, and first and second sidewalls. A filter is connected to the bottom. At least one blower is mounted in the housing. At least one air flow channel is connected to the blower and extends within the housing in an upward direction between two opposite ones of the first sidewalls. In the airflow channel clean air flows from the blower to the filter. Soundproofing material is connected to at least one side of the airflow channel.

Abstract: A method and apparatus for making a plurality of integral support plates for chairs, involving passing a strip of metallic material along a forming line and carrying our a series of operations on the strip, including: piercing and lancing holes, removing material adjacent the holes to permit use of a strip carrier, and cutting notches in opposed longitudinal sides at a first stage; then lancing the strip along two substantially transverse lines extending inwardly to the lancing holes; then carrying out a plurality of sequential operations for creating an integral, closed-ended sleeve projecting from the plate. A subsequent stage involves piercing the closed end of the sleeve and trimming away excessive edge material around the plate. At a later stage, reinforcement ribs are provided, along with any additional profiles that are needed. Then, mounting holes and any required slots are pierced. Finally, the completed support plate is cut from the strip.