Patents by Inventor Helmut Borner

Helmut Borner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the production of indole derivatives
    Patent number: 5401854
    Abstract: A process for the production of indole derivatives, which is characterized in that in the presence of phosphoric acid a substitution with an imine is performed, and intermediate products of this process and the production of these intermediate products are described.
    Type: Grant
    Filed: March 8, 1993
    Date of Patent: March 28, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Gregor Haffer, Helmut Borner, Wolfgang Kubler, Klaus Nickisch
  • Process for the production of N-.beta.-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-.beta.-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradeca ne derivatives and their metal complexes
    Patent number: 5386028
    Abstract: A process for the production of N-.beta.-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-.beta.-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetrade cane derivatives and their metal complexes is described.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: January 31, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulf Tilstam, Helmut Borner, Klaus Nickisch, Heinz Gries, Johannes Platzek
  • Selective phenylation of 5-hydroxy-.beta.-carboline derivatives
    Patent number: 5329009
    Abstract: Disclosed is chemoselective phenylation of 5-hydroxy-.beta.-carbolines in the presence of weak bases while adding water.
    Type: Grant
    Filed: March 19, 1992
    Date of Patent: July 12, 1994
    Assignee: Schering Aktiengesellschaft
    Inventors: Gregor Haffer, Helmut Borner, Klaus Nickisch, Julius Deutsch
  • Process for the preparation of 2-bromo-8-ergolinyl compounds
    Patent number: 4970314
    Abstract: 2-bromo-8-ergolinyl compounds of the formula ##STR1## wherein R.sup.8 is NH.sub.2, NH--CONEt.sub.2, CONH.sub.2, ##STR2## and ##STR3## wherein R.sup.1 =C.sub.1-4 -alkyl andR.sup.2 =C.sub.1-4 -alkyl and benzyl,R.sup.9 and R.sup.10 each mean hydrogen or, together, a bond, and the substituent R.sup.8 can be in the .alpha.- or .beta.- position, and their acid addition salts,can be prepared from corresponding 8-ergolinyl compounds and their acid addition salts by bromination with elemental bromine in the presence of hydrogen bromide in a halogenated hydrocarbon.
    Type: Grant
    Filed: November 5, 1984
    Date of Patent: November 13, 1990
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Borner, Gregor Haffer, Gerhard Sauer
  • Process for the production of .beta.-carbolines by dehydrogenation
    Patent number: 4644062
    Abstract: .beta.-carbolines of formula I ##STR1## wherein R=C.sub.1-5 alkylR.sup.4 =H, C.sub.1-5 alkyl or --(CH.sub.2).sub.n --OR with n=1 or 2 andR.sup.A =H, R, (CHR).sub.n --OR, OCH.sub.2 Ph, OPh, OPh(Cl,Br),OR,OCH.sub.2 Ph(Cl,Br) NRR, Cl or Br,wherein n and R have the above meanings and there are one or two R.sup.A 's are prepared, by dehydrogenation at reaction temperatures below ambient temperature in an inert solvent with tert-butyl hypochlorite and a tertiary amine.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: February 17, 1987
    Assignee: Schering Aktiengesellschaft
    Inventors: Gregor Haffer, Helmut Borner, Andreas Huth