Patents by Inventor Helmut Dahl

Helmut Dahl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6512139
    Abstract: The invention relates to the use of an oxidation inhibitor, i.e. active carbon, for ambient air in industrial manufacturing, especially in the processing of prostane derivatives, whereby the oxidation inhibitor removes ozone from the process air before contact with said prostane derivatives. The concentration of decomposition products is reduced.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: January 28, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: Torsten Wagner, Martin Wessel, Ralph Lipp, Bernd Iffert, Heinrich Michel, J├╝rgen Westermann, Helmut Dahl, Werner Skuballa
  • Patent number: 5403724
    Abstract: A process for production of 15-alpha-hydroxyprostaglandin intermediates of formula I ##STR1## wherein X is CH.sub.2,A is trans --CH.dbd.CH--B is ethylenedioxy or 2,2-dimethylpropylenedioxy,R.sub.1 is benzoyl, andR.sub.2 is ##STR2## by treating a ketone of formula II ##STR3## wherein A, B, X, R.sub.1 and R.sub.2 have the meanings indicated above, with a culture of Candida solani (NCYC 41) and isolating the resulting 15-alpha-hydroxyprostaglandin intermediate.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: April 4, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Helmut Dahl, Werner Skuballa
  • Patent number: 5248609
    Abstract: The invention relates to a process for the production of optically active (-)-oxabicyclo[3.3.0]octanolones of formula (-)-I ##STR1## wherein R is defined herein, comprising subjecting a racemic mixture of oxabicyclo[3.3.0]octanolone acylate to stereospecific acylate hydrolysis and separating the resultant products.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: September 28, 1993
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Helmut Dahl
  • Patent number: 5200530
    Abstract: The invention relates to a new process for the reduction of 15-keto carbacyclin intermediates in the presence of cerium(III) Salts.
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: April 6, 1993
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Dahl, Gabriela Buttner, Dieter Peschel
  • Patent number: 5102793
    Abstract: A microbiological process for sterospecific monoketo reduction of racemic 3-keto-bicyclic carbacyclin intermediates to the corresponding optically active 30.alpha. hydroxy compounds is provided.
    Type: Grant
    Filed: July 13, 1988
    Date of Patent: April 7, 1992
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Helmut Dahl, Helmut Vorbruggen
  • Patent number: 5010065
    Abstract: The invention relates to cyclodextrin clathrates of 5-cyanoprostacyclin analogs.
    Type: Grant
    Filed: November 28, 1988
    Date of Patent: April 23, 1991
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Skuballa, Helmut Dahl, Helmut Vorbrueggen, Olaf Loge, Karl-Heinz Thierauch
  • Patent number: 4925956
    Abstract: The invention relates to a process for manufacturing optically active carbacyclin intermediate products from racemic cis-bicyclo[3.3.0]octane-2-carboxylic acids. This process makes it possible in an advantageous way to produce important intermediates for the synthesis of stable and pharmacologically active carbacyclin derivatives.
    Type: Grant
    Filed: July 13, 1988
    Date of Patent: May 15, 1990
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Skuballa, Helmut Dahl
  • Patent number: 4894391
    Abstract: 5-Cyanoprostacyclins of Formula I ##STR1## wherein A is a --CH.sub.2 --CH.sub.2 --, trans--CH.dbd.CH--, or --C.tbd.C-group,W is a free or functionally modified hydroxymethylene group or a free or functionally modified ##STR2## wherein the OH-group can be in the .alpha.- or .beta.-position, D and E together form a direct bond orD is the group ##STR3## a straight-chain, saturated alkylene group of 1-5 carbon atoms, a branched, saturated or a straight-chain, unsaturated alkylene group of 2-5 carbon atoms, any of which can optionally be substituted by fluorine atoms,n is the number 1, 2, or 3,E is oxygen, sulfur, a --C.tbd.C-bond, a direct bond, or a --CR.sub.4 .dbd.CR.sub.5 -group wherein R.sub.4 and R.sub.5 are different and can be a hydrogen atom or an alkyl group of 1-3 carbon atoms,R.sub.2 is an alkyl, cycloalkyl, optionally substituted aryl, or heterocyclic group,R.sub.1 is a free or functionally modified hydroxy group, andR.sub.3 is an acetal residue ##STR4## wherein R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.
    Type: Grant
    Filed: June 25, 1984
    Date of Patent: January 16, 1990
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Skuballa, Helmut Dahl, Bernd Raduchel, Helmut Vorbruggen, Olaf Loge
  • Patent number: 4894336
    Abstract: Process for the production of optically active (+)-bicyclo[3.3.0]octanol derivatives of formula (+)-I, in which R.sub.1 and R.sub.2 represent jointly an oxygen atom or the double-bond residue --O--X--O-- with X as a straight or branched-chain alkylene with 1-7 C-atoms, or R.sub.1 and R.sub.2 represent separately the residue OR.sub.5 with R.sub.5 as a straight or branched-chain alkyl with 1-7 C-atoms, and R.sub.3 the residue COOZ with Z as a hydrogen atom, straight or branched chain alkyl with 1-7 C atoms, cycloalkyl with 3-6 C atoms, phenyl or aralkyl with 7-10 atoms or R.sub.3 is the residue --(CH.sub.2).sub.n --O--COR.sub.4 with n having the meaning 1-4 and R.sub.4 as a straight or branched-chain alkyl with 1-7 C atoms, cycloalkyl with 3-6 C atoms, phenyl or aralkyl with 7-10 C atoms. The process is characterized in that racemic 3.alpha.-cyloxy-cis-bicyclo[3.3.0]-octane derivatives of formula (+)-II, wherein R.sub.1, R.sub.2 R.sub.3 and R.sub.
    Type: Grant
    Filed: July 13, 1988
    Date of Patent: January 16, 1990
    Assignee: Schering Aktiengesellschaft
    Inventors: Karl Petzoldt, Helmut Dahl, Werner Skuballa
  • Patent number: 4886788
    Abstract: Cyclodextrin clathrates of carbacyclin analogs of general Formula I ##STR1## wherein R.sub.1 is hydrogen, alkyl or alkenyl of up to 10 carbon atoms,A is a --CH.sub.2 CH.sub.2 --, trans--CH.dbd.CH--, or --C.tbd.C-- group,W is a free or functionally modified hydroxymethylene group or a free or functionally modified ##STR2## wherein the OH-group can be in the .alpha.- or .beta.-position,D is ##STR3## alkylene, or unsaturated alkylene each of which can optionally be substituted by fluorine atoms,m is 1, 2 or 3,E is a direct bond, a --C.tbd.C-- group, or --CR.sub.4 .dbd.CR.sub.5 -- group, wherein R.sub.4 is hydrogen or an alkyl group of 1-5 carbon atoms, and R.sub.5 is hydrogen or an alkyl group of 1-5 carbon atoms, and R.sub.5 is hydrogen, halogen, or an alkyl group of 1-5 carbon atoms,R.sub.2 is alkyl or alkenyl of up to 10 carbon atoms, cycloalkyl of 3-10 carbon atoms or an optionally substituted aryl group of 6-10 carbon atoms, or a heterocyclic group, andR.sub.
    Type: Grant
    Filed: March 9, 1987
    Date of Patent: December 12, 1989
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Skuballa, Helmut Vorbrueggen, Helmut Dahl, Claus-Steffen Stuerzebecher, Karl-Heinz Thierauch
  • Patent number: 4247635
    Abstract: A process for the preparation of a 15 .alpha.-hydroxyprostaglandin intermediate of the formula ##STR1## wherein R.sub.1 is phenoxymethyl, phenoxymethyl substituted on the phenyl moiety by halogen or trifluoromethyl, or alkyl of 1-5 carbon atoms, andR.sub.2 is hydrogen, acetyl, benzoyl or p-phenylbenzoyl,which comprises stereospecifically microbiologically reducing a corresponding 15-ketone of the formula ##STR2## with a strain of the microorganism Kloeckera, Saccharomyces or Hansenula.
    Type: Grant
    Filed: December 5, 1979
    Date of Patent: January 27, 1981
    Assignee: Schering Aktiengesellschaft
    Inventors: Klaus Kieslich, Bernd Raduchel, Werner Skubalia, Helmut Vorbruggen, Helmut Dahl
  • Patent number: 4224320
    Abstract: Steroids of the formula ##STR1## wherein represents a single or double bond,X is hydrogen, fluorine or methyl;Y is hydrogen, hydroxy or alkanoyloxy of 1-6 carbon atoms;Z is hydrogen or methyl;V is methylene, ethylidene, hydroxymethylene or vinylidene; andR.sub.1 is alkyl of 1-6 carbon atoms or alkyl of 2-6 carbon atoms with an oxygen atom between two of the carbon atoms;R.sub.2 is hydrogen or alkyl of 1-6 carbon atoms, orR.sub.1 and R.sub.2 together form a tri- or tetramethylene group provided that Y is hydroxy or alkanoyloxy;have pharmacological activity and are useful as intermediates for preparing other pharmacologically active steroids.
    Type: Grant
    Filed: January 25, 1979
    Date of Patent: September 23, 1980
    Assignee: Schering, Aktiengesellschaft
    Inventors: Helmut Dahl, Ernst Schottle, Reinhold Wieske, Alfred Weber, Mario Kennecke
  • Patent number: 4207316
    Abstract: Corticoids of the formula ##STR1## wherein represents a single bond or a double bond;X is hydrogen, fluorine, chlorine or methyl;Y is hydrogen and Z is hydrogen, fluorine or chlorine, orY and Z together are a carbon-to-carbon bond;V is .beta.-hydroxymethylene, .beta.-chloromethylene or carbonyl;W is methylene, ethylidene or vinylidene;Q is oxygen or sulfur;R.sub.1 is alkyl of 1-8 carbon atoms, alkyl of 2-8 carbon atoms with an oxygen atom between two of the carbon atoms or benzyl, and R.sub.2 is hydrogen or alkyl of 1-4 carbon atoms, orR.sub.1 and R.sub.2 collectively are trimethylene or tetramethylene; andR.sub.3 is hydrogen, fluorine, chlorine, hydroxy, or hydroxy esterified by a C.sub.1-16 hydrocarbon carboxylic acid have valuable pharmacological properties, e.g., anti-inflammatory activity.
    Type: Grant
    Filed: January 25, 1979
    Date of Patent: June 10, 1980
    Assignee: Schering Aktiengesellschaft
    Inventors: Ernst Schottle, Alfred Weber, Mario Kennecke, Helmut Dahl, Joachim-Friedrich Kapp, Hans Wendt, Klaus Annen, Henry Laurent, Rudolf Wiechert
  • Patent number: 4179336
    Abstract: The side chains of sterols are degraded by fermentation with microorganisms capable of doing so in an improved manner by employing in such fermentations sterol derivatives of the formula ##STR1## wherein n is 1 or 2; R.sub.1 is H or lower alkyl, R.sub.2 is alkyl, whose chain optionally is interrupted by an oxygen atom, or when n is 2, also a hydrogen atom; and R.sub.3 is a sterol side chain.
    Type: Grant
    Filed: July 6, 1977
    Date of Patent: December 18, 1979
    Assignee: Schering Aktiengellschaft
    Inventors: Alfred Weber, Mario Kennecke, Helmut Dahl
  • Patent number: 4052447
    Abstract: Bicycloalkanes of the formula ##STR1## WHEREIN N IS THE INTEGER 1 OR 2; R is methyl or ethyl, and X and Y collectively are a free or ketalized oxo group or X is a hydrogen atom and y is a free, etherified or esterified hydroxy group, are produced by hydrogenating a compound of the formula ##STR2## WHEREIN N, R, X, and Y have the values given above and Me is an alkali metal atom, in an aqueous solution with hydrogen and a palladium-, platinum- or rhodium-containing hydrogenation catalyst. The corresponding free acid is obtained by acidifying the reaction mixture and isolating the reaction product.
    Type: Grant
    Filed: December 18, 1975
    Date of Patent: October 4, 1977
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Dahl, Hans Peter Lorenz