Patents by Inventor Helmut Hintner

Helmut Hintner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240124944
    Abstract: The present invention relates to systems and methods for screening compounds and/or mutant ribosomal proteins in a eukaryotic cell that increase or decrease the translation of a target gene and thereby ameliorate or revert a defective and/or undesired translation of a target gene. Disclosed are compounds and proteins as identified with the methods and systems of the invention, pharmaceutical and cosmetic compositions thereof, their uses for the preparation of a medicament, methods of treatment of a disease or condition or cosmetic condition related to the defective translation of a gene, for example genetic diseases such as Epidermolysis bullosa, as well as diagnostic measures practical for the clinical evaluation of such diseases or conditions. Also, kits are provided which comprise the identified compounds and/or proteins in addition to suitable means for performing the methods of the invention.
    Type: Application
    Filed: November 30, 2023
    Publication date: April 18, 2024
    Inventors: Hannelore BREITENBACH-KOLLER, Helmut HINTNER, Johann BAUER, Olaf HAUBENREISSER
  • Patent number: 11959145
    Abstract: The present invention relates to systems and methods for screening compounds and/or mutant ribosomal proteins in a eukaryotic cell that increase or decrease the translation of a target gene and thereby ameliorate or revert a defective and/or undesired translation of a target gene. Disclosed are compounds and proteins as identified with the methods and systems of the invention, pharmaceutical and cosmetic compositions thereof, their uses for the preparation of a medicament, methods of treatment of a disease or condition or cosmetic condition related to the defective translation of a gene, for example genetic diseases such as Epidermolysis bullosa, as well as diagnostic measures practical for the clinical evaluation of such diseases or conditions. Also, kits are provided which comprise the identified compounds and/or proteins in addition to suitable means for performing the methods of the invention.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: April 16, 2024
    Inventors: Hannelore Breitenbach-Koller, Helmut Hintner, Johann Bauer, Olaf Haubenreisser
  • Publication number: 20230288402
    Abstract: The present invention relates to a method for identifying a pharmaceutically active compound that modulates the rpL35 (rpL35/rpL29)-dependent translation of at least one mRNA in a mammalian cell. The mRNA may comprise a premature termination codon (PTC), undergoes premature translation termination, causes programmed ?1 ribosomal frame shifting (?1PRF), or is a polycistronic mRNA. Furthermore a respective screening system, methods of treating or preventing a disease or condition, and compounds that modulate the rpL35 (rpL35/rpL29)-dependent translation, in particular atazanavir or derivatives thereof and artemisinin or artesunate or derivatives thereof are provided.
    Type: Application
    Filed: July 30, 2021
    Publication date: September 14, 2023
    Inventors: HANNELORE BREITENBACH-KOLLER, JÖRG VON HAGEN, HELMUT HINTNER, FRIEDRICH LOTTSPEICH, HANS-WERNER MEWES, NORBERT MÜLLER, ANDREAS FRIEDRICH, KATHARINA ELSENSOHN, CLAUDIA MOSSHAMMER, MICHAEL WIESSNER, THOMAS KARL, JAN SCHERNTHANER, ADRIANA RATHNER
  • Publication number: 20120134983
    Abstract: The present invention relates to systems and methods for screening compounds and/or mutant ribosomal proteins in a eukaryotic cell that increase or decrease the translation of a target gene and thereby ameliorate or revert a defective and/or undesired translation of a target gene. Disclosed are compounds and proteins as identified with the methods and systems of the invention, pharmaceutical and cosmetic compositions thereof, their uses for the preparation of a medicament, methods of treatment of a disease or condition or cosmetic condition related to the defective translation of a gene, for example genetic diseases such as Epidermolysis bullosa, as well as diagnostic measures practical for the clinical evaluation of such diseases or conditions.
    Type: Application
    Filed: May 12, 2010
    Publication date: May 31, 2012
    Inventors: Hannelore Breitenbach-Koller, Helmut Hintner, Johann Bauer, Olaf Haubenreisser