Patents by Inventor Helmut Kalwass

Helmut Kalwass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic resolution of .alpha.-tertiary carboxylic acid esters
    Patent number: 5492830
    Abstract: A method for the resolution of .alpha.-tertiary carboxylic acid esters by partial hydrolysis is disclosed. The partial hydrolysis is carried out by contacting the esters with an aqueous solution in the presence of a serine carboxypeptidase, and the hydrolysis product is separated from unreacted starting material to obtain the hydrolysis product or the unreacted starting material in enantiomerically enriched form. A novel ester hydrolase which is particularly useful in this method, and a nucleotide sequence encoding this enzyme, are also described.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: February 20, 1996
    Assignee: Genzyme Corporation
    Inventors: Helmut Kalwass, Christopher Yee, Todd Blythe, Spencer Shames, Elizabeth Rogers