Abstract: This invention relates to ammonium salts and stable storable ammonium salts and ammonium salt/mineral salt clathrate compounds (inclusion compounds, clusters) having acid dibasic anionic acid residues such as bicarbonate, to methods for producing them and to pharmaco-medical and chemical synthetic applications for said compounds.

Abstract: The invention relates to the production and use of novel 14?-alkyl-18-norsteroids, 8?,14?-dialkyl-18-norsteroids, spiro[cyclopentano-perhydronaphthalin]-3,1?-pentanes or hexanes in addition to 14?-fluoro-15?,17?-dihydroxy-steroids, by reacting 17-hydroxy-14,15-epoxi-steroids with water-free acids or Lewis acids and followed by derivatisation. The resulting compounds can be used as intermediate products for or as medicaments in human and veterinary medicine, whereby the emphasis is on improving inflammatory processes, hormone replacement therapy and the use thereof as enzyme inhibitors in the treatment of tumours.

Abstract: A novel class of gonane type and D-homo-gonane type steroids having sulfatase-inhibiting and/or estrogenic activity is presented for application in the pharmaceutical industry. The number and location of sulfamoyloxy groups on the steroids provides for sulfatase inhibiting and estrogenic activities that independently vary over a wide range, allowing the customization of the pharmaceutical for specific purposes, including treatment and diagnosis of estrogen-dependent tumors.

Abstract: The invention relates to 11.beta.-aryl-gona-4,9-dienes of formula I ##STR1## wherein the variables are defined in the specification. The compounds are progesterone synthesis inhibitors and are suitable for inducing labor or an abortion, and for treating endometriosis, dysmenorrhea, and endocrine hormone-dependent tumors.

Abstract: This invention relates to 11.beta.-aryl-gona-4,9-dienes of the general formula I ##STR1## wherein the variables are defined in the specification. The compounds are progesterone antagonists and are suitable for inducing labor or an abortion.

Abstract: 11.sym.-Aryl-16.alpha.,17.alpha.-cyclohexano-estra-4,9-dienes of formula ##STR1## wherein R.sup.1 is H or a methyl group;R.sup.2 is --OCH.sub.3, --SCH.sub.3, --N(CH.sub.3).sub.2, --NHCH.sub.3, --CN, --CHO, --COCH.sub.3 or --CHOHCH.sub.3 ;X is --CHO, --COCH.sub.3, --CH.sub.2 OH, --CHOHCH.sub.3, --CH.sub.2 CHO--C.sub.1-7 -alkyl, --CH.sub.2 CHO--C.sub.1-7 -alkanoyl, --CH.sub.2 O--C.sub.1-7 -alkyl, --CH.sub.2 O--C.sub.1-7-alkanoyl, --COO--C.sub.1-7 -alkyl, CH.sub.3 CH.sub.2 --, --CH.sub.3, --COOH or --CN; andY is .dbd.O, .dbd.NOH, .dbd.NOCH.sub.3 or a cyclic thioketal having 2 or 3 ring atomsare provided, as well as pharmaceutical compositions containing said compounds, methods of use of said compounds, and processes for their production.

Abstract: 11.beta.-substituted-16.alpha., 17.alpha.-methylene-estra-4,9-dien-3-ones of formula I ##STR1## wherein R.sup.1 is a methyl or ethyl group;R.sup.2 is H; a C.sub.1-6 -alkyl, -alkoxymethyl, -alkanoyl or -alkoxcarbonyl group ; 2-methoxyethyl; 2-hydroxyethyl; 2-C.sub.1-4 -alkanoyloxyethyl; or a tri-C.sub.1-4 -alkylsilyl group;R.sup.3 is vinyl; a C.sub.1-6 -alkyl; or a phenyl radical para-substituted by --OCH.sub.3, --SCH.sub.3, --N(CH.sub.3), --CN, --CHO, CH.sub.3 CO--, CH.sub.3 CHOH-- or --CH.sub.2 OH;R.sup.6 is H or a C.sub.1-4 -alkyl group;X is O, a hydroxy- or methoxyimino group (.dbd.N.about.OH or --N.about.OCH.sub.3), or a cyclic thioketal with 2 or 3 carbon ring atomsare provided, as well as pharmaceutical compositions containing said compounds, methods of use of said compounds, and processes for their production.

Abstract: Gona-1,3,5(10),9(11)-tetraenes having the formula ##STR1## IN WHICH FORMULA N IS 1 OR 2,R.sup.1 is a hydrogen, hydroxy, alkoxy, or alkanoyl substituent,R.sup.2 is a hydrogen, alkoxy, acetoxy, alkyl, akenyl, or alkynyl substituent, or a substituent having the formula --CH.sub.2 X in which X is a halogen, pseudohalogen, or O-alkyl substituent, orR.sup.1 or R.sup.2 together are oxygen, or a methyleneoxy or ethylenedioxy substituent,R.sup.3 is a hydroxy, alkoxy, alkanoyl, or alkoxymethyleneoxy substituent, andR.sup.4 is a methyl or ethyl substituent,Are made from gona-1,3,5(10)trienes by electrolysis of a solution thereof in water and/or a primary or secondary alcohol in the presence of an electroconductive compound.The gona-1,3,5(10),9(11)-tetraenes are intermediates for the production of steroidal pharmaceuticals for fertility control in human and animal therapeutics.