Abstract: A microtome, in particular an ultramicrotome, has a drive-control system by which the movement of the specimen arm, relative to the knife, is subdivided into a comparatively slow cutting movement and a more rapid return movement. The drive-control system gradually decelerates the specimen arm at the transition, from the comparatively rapid return movement to the slower cutting movement, so that a jerk, which would generate mechanical vibrations in the drive system, is avoided and the specimen arm is smoothly decelerated from the comparatively high speed to the lower speed.