Patents by Inventor Helmut Pieper

Helmut Pieper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090163480
    Abstract: The present invention relates to modified amino acids of general formula wherein A, Z, X, n, m, R, R2, R3, R4 and R11 are defined as in claims 1 to 5, their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.
    Type: Application
    Filed: December 17, 2008
    Publication date: June 25, 2009
    Applicant: Dr. Karl Thomae GmbH
    Inventors: Klaus RUDOLF, Wolfgang EBERLEIN, Wolfhard ENGEL, Helmut PIEPER, Henri DOODS, Gerhard HALLERMAYER, Michael ENTZEROTH, Wolfgang WIENEN
  • Patent number: 7498325
    Abstract: The present invention relates to modified amino acids of general formula wherein A, Z, X, n, m, R, R2, R3, R4 and R11 are defined as in claims 1 to 5, their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: March 3, 2009
    Assignee: Karl Thomas GmbH
    Inventors: Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Helmut Pieper, Henri Doods, Gerhard Hallermayer, Michael Entzeroth, Wolfgang Wienen
  • Publication number: 20040214819
    Abstract: The present invention relates to modified amino acids of general formula 1
    Type: Application
    Filed: April 29, 2004
    Publication date: October 28, 2004
    Applicant: Dr. Karl Thomae GmbH
    Inventors: Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Helmut Pieper, Henri Doods, Gerhard Hallermayer, Michael Entzeroth, Wolfgang Wienen
  • Publication number: 20030069231
    Abstract: The present invention relates to modified amino acids of general formula 1
    Type: Application
    Filed: April 10, 2002
    Publication date: April 10, 2003
    Inventors: Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Helmut Pieper, Henri Doods, Gerhard Hallermayer, Michael Entzeroth, Wolfgang Wienen
  • Patent number: 6344449
    Abstract: The present invention relates to modified amino acids of general formula wherein A, Z, X, n, m, R, R2, R3, R4 and R11 are defined as in claims 1 to 5, their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: February 5, 2002
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Helmut Pieper, Henri Doods, Gerhard Hallermayer, Michael Entzeroth, Wolfgang Wienen
  • Publication number: 20010036946
    Abstract: The present invention relates to modified amino acids of general formula 1
    Type: Application
    Filed: February 21, 2001
    Publication date: November 1, 2001
    Inventors: Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Helmut Pieper, Henri Doods, Gerhard Hallermayer, Michael Entzeroth, Wolfgang Wienen
  • Patent number: 6289694
    Abstract: During the melting of glass from charging material in furnaces with burners and regenerators for the recovery of waste heat, oxygen and primary fuel are introduced into the area around the flame roots under slightly sub-stoichiometric conditions to cover the heat requirement of the melting process. In order to further reduce the levels of NOx, and CO in the waste gases by re-burning or post oxidation, secondary fuel and, further downstream, additional air are introduced beyond the flame in order to reduce the level of NOx, in or above the checkerwork by means of the secondary fuel and to carry out re-burning or post oxidation downstream by means of the supply of air, so that ultimately approximately stoichiometric combustion takes place. Before the waste gases enter a waste gas stack they are used to preheat the charging material in at least one raw material pre-heater.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: September 18, 2001
    Assignee: Beteiligungen Sorg GmbH & Co. KG
    Inventor: Helmut Pieper
  • Patent number: 6154481
    Abstract: In a glass melting furnace, a radiation screen wall is installed between a melting area and a refining area with a refining bank. This radiation screen wall leaves a flow path above the melt surface of the glass bath for the return flow of at least part of the combustion gases from the refining area to the melting area. In order to suppress a return flow of already refined and very hot glass melt from the refining area into a melting area, but still allow the charging material to melt completely as early as possible, the furnace is operated to produce at least one upward current between the middle of the melting area and the front face of the refining bank in the glass melt.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: November 28, 2000
    Assignee: Beteiligungen Sorg GmbH Co. KG
    Inventors: Helmut Sorg, Helmut Pieper
  • Patent number: 6085551
    Abstract: In the manufacturing of high melting point glasses with volatile components, in particular of glasses from the group of boron glasses and borosilicate glasses, a furnace is provided that has a superstructure, fossil fuel burners, and a melting tank. In front of a conditioning zone and a throat leading to an extraction zone, a step-shaped raised area in the bottom is provided which is formed continuously over the complete width of the melting tank. In order to suppress segregation or, respectively, phase separation, to protect the furnace construction materials and to enable problem-free operation, a temperature of at least 1600.degree. C.
    Type: Grant
    Filed: April 2, 1998
    Date of Patent: July 11, 2000
    Assignee: Beteiligungen Sorg GmbH & Co. KG
    Inventors: Helmut Pieper, Joachim Matthes
  • Patent number: 5994356
    Abstract: The present invention relates to carboxylic acid derivatives of the general formula ##STR1## in which R.sub.a to R.sub.c, A, B, D, E and X.sub.1 to X.sub.3 are as defined in claim 1, their tautomers, their stereoisomers including their mixtures, and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases, which have useful pharmacological properties, preferably aggregation-inhibiting inhibiting actions, medicaments containing these compounds, their use and processes for their preparation.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: November 30, 1999
    Assignee: Karl Thomae
    Inventors: Helmut Pieper, Gunter Linz, Volkhard Austel, Frank Himmelsbach, Brian Guth, Johannes Weisenberger
  • Patent number: 5958952
    Abstract: The present invention relates to phenyl amidines of general formula (I), ##STR1## in which R.sup.1 to R.sup.5 are as defined in claim 1, their tautomers, their stereoisomers and their mixtures and their salts, especially their physiologically acceptable salts with inorganic or organic acids or bases also having valuable pharmacological properties, preferably aggregation-limiting effects, producing them.
    Type: Grant
    Filed: December 17, 1997
    Date of Patent: September 28, 1999
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Volkhard Austel, Gunther Linz, Helmut Pieper, Brian Guth, Johannes Weisenberger
  • Patent number: 5922717
    Abstract: The present invention relates to piperazine derivatives of the general formula ##STR1## in which R.sub.a, Y.sub.1 to Y.sub.3 and E are defined herein, tautomers thereof, stereoisomers thereof, including their mixtures, and salts thereof, and in particular physiologically tolerated salts thereof with inorganic or organic acids or bases. These compounds have valuable pharmacological properties, such as aggregation-inhibiting activity. This invention also relates to medicaments comprising these compounds and to processes for the preparation of these compounds.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: July 13, 1999
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Helmut Pieper, Volkhard Austel, Frank Himmelsbach, Gunter Linz, Brian Guth, Johannes Weisenberger
  • Patent number: 5922763
    Abstract: The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing these compounds and processes for preparing them.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: July 13, 1999
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Helmut Pieper, Volkhard Austel, Gunter Linz, Thomas Muller, Wolfgang Eisert, Johannes Weisenberger
  • Patent number: 5880284
    Abstract: The invention relates to cyclic urea derivatives of general formula I ##STR1## wherein R.sub.a, R.sub.b, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation inhibiting effects, and to drugs containing the compounds and processes for preparing them.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: March 9, 1999
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Volkhard Austel, Gunter Linz, Helmut Pieper, Brian Guth, Thomas Muller, Johannes Weisenberger
  • Patent number: 5852192
    Abstract: The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: December 22, 1998
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Helmut Pieper, Volkhard Austel, Guenter Linz, Johannes Weisenberger, Wolfgang Eisert, Thomas Mueller
  • Patent number: 5827849
    Abstract: The invention relates to cyclic derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined in claim 1, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: October 27, 1998
    Assignee: Karl Thomae GmbH
    Inventors: F. Himmelsbach, Helmut Pieper, Volkhard Austel, Gunter Linz, Brian Guth, Thomas Muller, Johannes Weisenberger
  • Patent number: 5817677
    Abstract: 5-Membered heterocyclic compounds, of which the following compounds are exemplary:(a) 4-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-1-(4-piperidyl)imida zole,(b) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-4-methyl-2-(4-piperi dyl)-1,3-thiazole,(c) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-t hiazole,(d) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3, 4-thiadiazole,(e) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiaz ole,(f) 5-??trans-4-(carboxymethoxy)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3- thiazole,(g) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole,(h) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3- thiazole, and(i) 4-??trans-4-carboxycyclohexyl!aminocarbonyl!-1-?2-(4-piperidyl)ethyl!imida zole.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: October 6, 1998
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Gunter Linz, Frank Himmelsbach, Helmut Pieper, Volkhard Austel, Brian Guth, Johannes Weisenberger
  • Patent number: 5755846
    Abstract: A method of operating a regenerative glass melting furnace with end-firing or cross-firing utilizes burners to provide sub-stoichiometric combustion and super-stoichiometric combustion along the sidewalls or transverse walls of the furnace and equipment associated with the method. Fuel supply is controlled so that overall combustion is stoichiometric.
    Type: Grant
    Filed: May 10, 1994
    Date of Patent: May 26, 1998
    Assignee: Beteiligungen Sorg GmbH & Co. KG
    Inventors: Manfred Wagner, Klaus Sorg, Helmut Pieper
  • Patent number: 5736559
    Abstract: The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing these compounds and processes for preparing them.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: April 7, 1998
    Assignee: Karl Thomae GmbH
    Inventors: Frank Himmelsbach, Helmut Pieper, Volkhard Austel, Gunter Linz, Thomas Muller, Wolfgang Eisert, Johannes Weisenberger
  • Patent number: 5728190
    Abstract: A tank furnace for the inertization of non-flammable batch, which contains hazardous substances, metals and less than 10% by weight of carbon, by vitrification with glass forming aggregates by producing a glassy melt. The furnace has a batch charging device and a tank, on the rim of which a furnace crown rests, electrodes for heating the melt, a supply of oxidizing gases to the melt and, as an outlet for the melt, an overflow channel which can be heated. Nozzles are installed in the bottom of the tank to introduce oxidizing gases in order to reduce the eluate values, and the electrodes are immersed in the melt from above. It is preferable to install the nozzles at sloping sidewalls of the tank which slope upwardly and outwardly.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: March 17, 1998
    Assignee: Beteiligungen Sorg GmbH & Co. AG
    Inventors: Helmut Pieper, Lothar Rott, Matjaz Bucar