Patents by Inventor Helmut Robert Macke

Helmut Robert Macke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide compounds having improved binding affinity to somatostatin receptors
    Patent number: 7122622
    Abstract: The invention relates to a peptide compound having an improved binding affinity to somatostatin receptors, comprising a somatostatin analogue as the peptide and a chelating group covalently linked to the N-terminal free amino group of said peptide, wherein said somatostatin analogue carries an 1-naphthylalanine or a 3-benzothienylalanine residue in its 3-position. The invention further relates to said peptide compound labeled with a detectable element or with a therapeutic radionuclide, as well as to a diagnostic method and to a method for the therapeutic treatment of tumors, by using the labeled compounds.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: October 17, 2006
    Assignee: BioSynthema Inc.
    Inventors: Helmut Robert Macke, Jean-Claude Reubi, Jörg Simon Schmitt, Mihaela Ginj
  • Peptide compounds having improved binding affinity to somatostatin receptors
    Publication number: 20040044177
    Abstract: The invention relates to a peptide compound having an improved binding affinity to somatostatin receptors, comprising a somatostatin analogue as the peptide and a chelating group covalently linked to the N-terminal free amino group of said peptide, wherein said somatostatin analogue carries an 1-naphthylalanine or a 3-benzothienylalanine residue in its 3-position. The invention further relates to said peptide compound labeled with a detectable element or with a therapeutic radionuclide, as well as to a diagnostic method and to a method for the therapeutic treatment of tumors, by using the labeled compounds.
    Type: Application
    Filed: April 16, 2003
    Publication date: March 4, 2004
    Inventors: Helmut Robert Macke, Jean-Claude Reubi, Jorg Simon Schmitt, Mihaela Ginj