Patents by Inventor Helmut Stahr

Helmut Stahr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOLID FORMS OF (S)-2-METHOXY-3--PROPIONIC ACID AND OF SALTS THEREOF
    Publication number: 20170281602
    Abstract: The present invention relates to solid forms of (S)-2-methoxy-3-{442-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxyl-benzo[b]thiophen-7-yl}-propionic acid, and of salts of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid.
    Type: Application
    Filed: June 14, 2017
    Publication date: October 5, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lukas Dreier, Andre Egli, Karsten Faehnrich, Olaf Grassmann, Peter Mohr, Urs Schwitter, Helmut Stahr, Nicole Wyttenbach
  • SOLID FORMS OF (S)-2-METHOXY-3--PROPIONIC ACID AND OF SALTS THEREOF
    Publication number: 20150182505
    Abstract: The present invention relates to solid forms of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid, and of salts of (S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid.
    Type: Application
    Filed: March 11, 2015
    Publication date: July 2, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lukas Dreier, Andre Egli, Karsten Faehnrich, Olaf Grassman, Peter Mohr, Urs Schwitter, Helmut Stahr, Nicole Wyttenbach
  • Preparation for a cyclohexanecarboxylic acid derivative and intermediates
    Patent number: 8143442
    Abstract: A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: March 27, 2012
    Assignee: Hoffmann-LA Roche Inc.
    Inventors: Gerard John Harnett, Ursula Hoffmann, Michael Jansen, Reinhard Reents, Tim Sattelkau, Dennis A. Smith, Helmut Stahr
  • Process for the preparation of a macrocycle
    Patent number: 8106187
    Abstract: The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula wherein R1 is an amino protecting group and X is halogen by way of a ring closing metathesis approach.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: January 31, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Michelangelo Scalone, Helmut Stahr
  • Process for cyclohexanecarboxylic acid derivatives
    Patent number: 7858823
    Abstract: A process for the preparation of a compound of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: December 28, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ursula Hoffmann, Michael Jansen, Reinhard Reents, Helmut Stahr
  • Process for the preparation of macrocyclic compounds
    Patent number: 7847106
    Abstract: The present invention relates to a new process for the preparation of tripeptides of formula I wherein R1 is an amino protecting group and X is a halogen atom and wherein the tipeptide contains two olefinic moieties suitably disposed to undergo an intramolecular olefin metathesis reaction and produce macrocyclic tripeptides useful for the manufacture of macrocyclic HCV protease inhibitors.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: December 7, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Francois Gantz, Helmut Stahr
  • Process for the preparation of a macrocycle
    Publication number: 20100036116
    Abstract: The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula wherein R1 is an amino protecting group and X is halogen by way of a ring closing metathesis approach.
    Type: Application
    Filed: August 7, 2009
    Publication date: February 11, 2010
    Inventors: Michelangelo Scalone, Helmut Stahr
  • PREPARATION FOR A CYCLOHEXANECARBOXYLIC ACID DERIVATIVE AND INTERMEDIATES
    Publication number: 20090253928
    Abstract: A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Application
    Filed: March 31, 2009
    Publication date: October 8, 2009
    Inventors: Gerard John Harnett, Ursula Hoffmann, Michael Jansen, Reinhard Reents, Tim Sattelkau, Dennis A. Smith, Helmut Stahr
  • PROCESS FOR CYCLOHEXANECARBOXYLIC ACID DERIVATIVES
    Publication number: 20090253927
    Abstract: A process for the preparation of a compound of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
    Type: Application
    Filed: March 31, 2009
    Publication date: October 8, 2009
    Inventors: Ursula Hoffmann, Michael Jansen, Reinhard Reents, Helmut Stahr
  • Process for the preparation of macrocyclic compounds
    Publication number: 20080269502
    Abstract: The present invention relates to a new process for the preparation of diene compounds of the formula I wherein R1 is an amino protecting group and X is a halogen atom which may serve as intermediates for the manufacture of macrocyclic HCV protease inhibitors.
    Type: Application
    Filed: April 24, 2008
    Publication date: October 30, 2008
    Inventors: Francois Gantz, Helmut Stahr
  • Process for the preparation of the insulin sensitizer
    Patent number: 7259176
    Abstract: A novel process for the preparation of compounds of formula I and optionally converting a compound of formula I into a pharmaceutically acceptable salt is disclosed. The compounds of formula I and the corresponding salts, e.g. the sodium salts, are pharmaceutically active substances. Processes for the creation of intermediates are also disclosed.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: August 21, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wolfgang Goehring, Ursula Hoffmann, Michelangelo Scalone, Helmut Stahr, Shaoning Wang
  • Novel process for the preparation of the insulin sensitizer
    Publication number: 20040267023
    Abstract: A novel process for the preparation of compounds of formula I 1
    Type: Application
    Filed: June 21, 2004
    Publication date: December 30, 2004
    Inventors: Wolfgang Goehring, Ursula Hoffmann, Michelangelo Scalone, Helmut Stahr, Shaoning Wang
  • Method of producing 3,4-dehydroprolines and 3,4-dehydropiperidines
    Patent number: 6579971
    Abstract: A process for preparing compounds of the formula I in which R is hydrogen, C1-C6-alkoxy, —NHC1-C6-alkyl, —N(C1-C6-alkyl)2, OH, NH2 R1 is hydrogen, C1-C6-alkyl, Me3Si, C1-C6-alkyl-S R2 is Boc, C1-C6-acyl, mesyl, benzenesulfonyl, tosyl, trifluoroacetyl, A1-A3-peptide n is 1, 2 R4 is H, C1-C6-alkyl, is described.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: June 17, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Schäfer, Günter Helmchen, Uli Kazmaier, Simone Schleich, Helmut Stahr, Volker Wolfart