Patents by Inventor Helmut Wachtel
Helmut Wachtel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6191132Abstract: The new use of antagonists of the AMPA receptor complex and its physiologically compatible salts as pharmaceutical agents for prevention and treatment of Parkinson's disease as well as pharmaceutical agents, which contain these compounds, is described.Type: GrantFiled: November 4, 1993Date of Patent: February 20, 2001Assignee: Schering AktiengesellschaftInventors: Thomas Klockgether, Peter-Andreas Löschmann, David Norman Stephens, Lechoslaw Turski, Helmut Wachtel
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Patent number: 6117895Abstract: Compounds of formula I ##STR1## are useful for treating TNF-mediated diseases.Type: GrantFiled: July 18, 1996Date of Patent: September 12, 2000Assignee: Schering AktiengesellschaftInventors: Helmut Wachtel, Hermann Graf, Herbert Schneider, Daryl Faulds, H. Daniel Perez, Harald Dinter
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Patent number: 6060501Abstract: A pharmaceutically composition for treating MS comprising an effective amount of a combination of a PDE IV inhibitor and an anti-inflammatory and immunomodulatory drug in a pharmaceutically acceptable carrier.Type: GrantFiled: September 24, 1997Date of Patent: May 9, 2000Assignee: Schering AktiengesellschaftInventors: Helmut Wachtel, Peter-Andreas Loschmann, Hermann Graf, H. Daniel Perez
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Patent number: 6025376Abstract: This invention relates to (R)-(-)-methylphenyloxazolidinone derivatives, a process for their production and their use as pharmaceutical agents.Type: GrantFiled: August 2, 1996Date of Patent: February 15, 2000Assignee: Schering AktiengesellschaftInventors: Henry Laurent, Eckhard Ottow, Gerald Kirsch, Helmut Wachtel, Herbert Schneider, Daryl Faulds, Harald Dinter
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Patent number: 6011060Abstract: Described are racemic and enantiomerically pure chiral phenyldihydrofuranones, their preparation and their use in drugs (selective inhibition of the cAMP-specific phosphodiesterase IV).Type: GrantFiled: December 11, 1998Date of Patent: January 4, 2000Assignee: Schering AktiengesellschaftInventors: Henry Laurent, Peter Esperling, Kurt Hamp, Herbert Schneider, Helmut Wachtel
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Patent number: 5847010Abstract: The present invention is a method of preventing or ameliorating the episodic recurrence of MS, comprising administering an effective amount of selective phosphodiesterase inhibitors of Type IV, e.g., Rolipram, e.g., wherein the severity of the episodic recurrences is ameliorated or the time period between episodes is lengthened.Type: GrantFiled: September 22, 1997Date of Patent: December 8, 1998Assignee: Berlex Laboratories, Inc.Inventors: Joel Hedgpeth, Helmut Wachtel
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Patent number: 5672622Abstract: The present invention is a method of preventing or ameliorating the episodic recurrence of MS, comprising administering an effective amount of selective phosphodiesterase inhibitors of Type IV, e.g., Rolipram, e.g., wherein the severity of the episodic recurrences is ameliorated or the time period between episodes is lengthened.Type: GrantFiled: October 21, 1994Date of Patent: September 30, 1997Assignee: Berlex Laboratories, Inc.Inventors: Joseph Hedgepeth, Helmut Wachtel
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Patent number: 5547958Abstract: 8.alpha.-acylamino ergolines are useful dopamine agonists.Type: GrantFiled: December 27, 1994Date of Patent: August 20, 1996Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Thomas Brumby, Helmut Wachtel, Jonathan Turner, Peter-Andreas Loschmann
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Patent number: 5411966Abstract: Compounds of formula I and their acid addition salts ##STR1## in which R.sup.2 R.sup.6 R.sup.13 and X have the meanings defined herein are described as well as a process and intermediates for their production, and pharmaceutical agents containing these compounds.Type: GrantFiled: September 27, 1993Date of Patent: May 2, 1995Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Bernd Schroter, Thomas Brumby, Helmut Wachtel, Peter A. Loschmann
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Patent number: 5401748Abstract: 2,14-Disubstituted ergolines of formula I ##STR1## in which R, R.sup.2, R.sup.6, R.sup.14 and X have the meaning named in the application, as well as their production and use in pharmaceutical agents, are described.Type: GrantFiled: March 12, 1993Date of Patent: March 28, 1995Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Helmut Wachtel, Peter A. Loschmann
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Patent number: 5242678Abstract: Compounds of general Formula I labeled with 7.sup.5 Br, .sup.76 Br, .sup.77 Br, .sup.80m Br or .sup.80 Br isotopes ##STR1## wherein R.sup.6 is a C.sub.1-6 hydrocarbon residue and C.sub.2 C.sub.3, C.sub.9 C.sub.10 is a single or a double bond, as well as their acid addition salts, as diagnostic media to image dopamine.Type: GrantFiled: June 26, 1989Date of Patent: September 7, 1993Assignee: Schering AktiengesellschaftInventors: Bernard Maziere, Helmut Wachtel, Peter-Andreas Loeschmann, Rainer Dorow, Bernard Acksteiner, Dominique Comar, Christian Loch
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Patent number: 5219862Abstract: Compounds of formula I ##STR1## in which R.sup.2 means optionally substituted C.sub.1-7 alkyl, C.sub.2-7 alkenyl, CH.sub.2 --O--C.sub.1-4 alkyl or CH.sub.2 --S--C.sub.1-4 alkylR.sup.6 means C.sub.2-6 alkyl, C.sub.3-6 alkenyl or C.sub.3-5 -cycloalkyl-C.sub.1-2 alkyl andR.sup.8 means CH.sub.2 --X, ##STR2## in which X stands for CN, OCH.sub.3, SCH.sub.3 or CONH.sub.2 and R.sup.1 stands for hydrogen, halogen, methyl or methoxy, and R.sup.3 and R.sup.4 each mean C.sub.1-4 alkyl or (CH.sub.2).sub.n --N(CH.sub.3).sub.2, in which n=1-4, and their acid addition salts, the process for their production, their use as pharmaceutical agents as well as intermediate compounds are described.Type: GrantFiled: December 21, 1990Date of Patent: June 15, 1993Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Thomas Brumby, Helmut Wachtel, Jonathan Turner, Peter A. Loschmann
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Patent number: 5212178Abstract: 8.alpha.-acylamino ergolines are useful dopamine agonists.Type: GrantFiled: May 14, 1990Date of Patent: May 18, 1993Assignee: Schering AktiengesellschaftInventors: Gerhard Sauer, Thomas Brumby, Helmut Wachtel, Jonathan Turner, Peter-Andreas Loschmann
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Patent number: 5158957Abstract: 2-Substituted ergolines ##STR1## wherein C.sub.2 C.sub.3 and C.sub.9 C.sub.10 represent a single of double bond;X is oxygen or sulfur;R.sup.2 is C.sub.1-10 alkyl, optionally halogen-substituted C.sub.2-10 alkenyl, CH.sub.2 YR.sup.3, CR.sup.12 (OR.sup.4)R.sup.5, CH.sub.2 --CHR.sup.9 --COR.sup.10 or COR.sup.12,whereinY is oxygen or sulfur,R.sup.3 is hydrogen, C.sub.1-4 alkyl, phenyl, C.sub.2-5 acyl or phenyl C.sub.1-4 alkyl,R.sup.4 is hydrogen or C.sub.2-5 acyl,R.sup.5 is C.sub.1-9 alkyl,R.sup.9 is COCH.sub.3 or COO-C.sub.1-4 alkyl,R.sup.10 is C.sub.1-4 alkyl or O-C.sub.1-4 alkyl,R.sup.12 is hydrogen or C.sub.1-9 alkyl; andR.sup.6 is C.sub.2-10 alkyl, C.sub.3-10 alkenyl or C.sub.4-10 cycloalkyl-C.sub.1-3 -alkyl,and acid addition salts, isomers and isomeric mixtures thereof are dopaminergic agonists and useful for treating Parkinson's Disease.Type: GrantFiled: June 26, 1991Date of Patent: October 27, 1992Assignee: Schering AktiengesellschaftInventors: Thomas Brumby, Gerhard Sauer, Josef Heindl, Jonathan Turner, Gerhard Kuhne, Helmut Wachtel
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Patent number: 5064854Abstract: Compounds of general Formula I are disclosed ##STR1## wherein R.sup.1 is C.sub.1-4 -alkyl,R.sup.3 is hydrogen, C.sub.1-4 -alkyl, acyl, aryl,R.sup.5 is hydrogen, C.sub.1-4 -alkyl,X is oxygen, CH.sub.2 or NR.sup.4 with R.sup.4 =hydrogen, C.sub.1-4 -alkyl andY is an aromatic or nonaromatic ring system which can optionally contain one to two hetero atoms and can be substituted, and the stereoisomers and their mixtures,as well as their preparation and use as medicinal agents.Type: GrantFiled: July 7, 1989Date of Patent: November 12, 1991Assignee: Schering AktiengesellschaftInventors: Andreas Huth, Ralph Schmiechen, Helmut Wachtel, Herbert H. Schneider
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Patent number: 5059612Abstract: The invention relates to a method of treating dementia, such as cerebro-vascular dementia, for example, multiple infarct dementia and amyloid angiopathic dementia, cerebro-parenchymatous dementia, such as Alzheimer's dementia and Pick's disease, and dementia caused by brain tumor, hydrocephalus, hepatic meningitis, cerebral trauma, or cerebral function disorders, comprising administering rolipram.Type: GrantFiled: September 7, 1990Date of Patent: October 22, 1991Assignee: Schering AktiengesellschaftInventors: Taiichiro Imanishi, Yasuyuki Ichimaru, Aiko Sawa, Fukio Konno, Helmut Wachtel, Showa Ueki, Michihiro Fujiwara, Tsuneyuki Yamamoto
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Patent number: 5037832Abstract: 2-Substituted ergolines ##STR1## wherein C.sub.2 C.sub.3 and C.sub.9 C.sub.10 represent a single or double bond;X is oxygen or sulfur;R.sup.2 is C.sub.1-10 alkyl, optionally halogen-substituted C.sub.2-10 alkenyl, CH.sub.2 YR.sup.3, CR.sup.12 (OR.sup.4)R.sup.5, CH.sub.2 -CHR.sup.9 -COR.sup.10 or COR.sup.12, whereinY is oxygen or sulfur,R.sup.3 is hydrogen, C.sub.1-4 alkyl, phenyl, C.sub.2-5 acyl or phenyl C.sub.1-4 alkyl,R.sup.4 is hydrogen or C.sub.2-5 acyl,R.sup.5 is C.sub.1-9 alkyl,R.sup.9 is COCH.sub.3 or COO-C.sub.1-4 alkyl,R.sup.10 is C.sub.1-4 alkyl or O-C.sub.1-4 alkyl,R.sup.12 is hydrogen or C.sub.1-9 alkyl; andR.sup.6 is C.sub.2-10 alkyl, C.sub.3-10 alkenyl or C.sub.4-10 cycloalkyl-C.sub.1-3 -alkyl,and acid addition salts, isomers and isomeric mixtures thereof are dopaminergic agonists and useful for treating Parkinson's Disease.Type: GrantFiled: July 17, 1989Date of Patent: August 6, 1991Assignee: Schering AktiengesellschaftInventors: Thomas Brumby, Gerhard Sauer, Josef Heindl, Jonathan Turner, Gerhard Kuhne, Helmut Wachtel
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Patent number: 4970200Abstract: The enzyme cofactor nicotinamide adenine dinucleotide or a salt thereof is useful for the treatment of Parkinson's disease.Type: GrantFiled: March 1, 1989Date of Patent: November 13, 1990Assignee: Schering AktiengesellschaftInventors: Walther Birkmayer, Jorg Birkmayer, Reinhard Horowski, Helmut Wachtel, Peter-Andreas Loschmann
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Patent number: 4925854Abstract: Benzimidazole derivatives of general Formula I ##STR1## wherein R.sup.1 and R.sup.2, being identical or different, each mean hydrogen or an optionally substituted hydrocarbon residue andX is oxygen or sulfur,as well as the acid addition salts thereof, are useful, e.g., as dopaminergic agents.Type: GrantFiled: August 25, 1988Date of Patent: May 15, 1990Assignee: Schering AktiengesellschaftInventors: Klaus Schollkopf, Helmut Wachtel
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Patent number: 4874768Abstract: The disclosure relates to 1,2-substituted ergoline derivatives of general Formula I ##STR1## wherein X is an oxygen or sulfur atom,R.sup.1 is a lower alkyl group,R.sup.2 is halogen, acyl, a saturated or unsaturated lower alkyl group which can optionally be substituted by OR.sup.4 wherein R.sup.4 is hydrogen, lower alkyl, tetrahydropyranyl or cycloalkyl, or by an optionally substituted aryl residue, an S-R.sup.5 -group wherein R.sup.5 means a lower alkyl group which can optionally be substituted by aryl or an optionally substituted aryl residue, a ##STR2## wherein n=2 o4 3, or a --CHO-group, R.sup.3 is lower alkyl or acyl, andC.sub.9 -C.sub.10 is a CC-single or a CC-double bond, and the hydrogen atom in the 10-position is in the .alpha.-location if C.sub.9 -C.sub.10 is a CC-single bond, as well as the acid addition salts thereof. The compounds exhibit valuable pharmacological properties.Type: GrantFiled: October 6, 1986Date of Patent: October 17, 1989Assignee: Schering AktiengesellschaftInventors: Andreas Huth, Gerhard Sauer, Helmut Wachtel