Patents by Inventor Helmut Wahlig
Helmut Wahlig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8003121Abstract: System of implant components containing active agents, wherein each component is intended to function as an additive for an implant material produced with a powdery or finely granulated starting material and/or active agents and additives. Each component is powdery or finely granulated and includes at least one powdery or finely granulated active agent or additive having a higher dosage than the desired concentration for the application. The components themselves are made of a powdery or finely granulated starting material for the implant material, as well as of the active agent or additive. The active agents can be chemotherapeutical agents, such as antibiotics, whereas the additives can be x-ray contrast materials and/or or additives that alter the physical properties of the starting material, such as its elasticity or viscosity.Type: GrantFiled: August 1, 2000Date of Patent: August 23, 2011Assignee: aap Biomaterials GmbH & Co. KGInventors: Elvira Dingeldein, Helmut Wahlig, Jörg Bauer, Edgar Wüst, Christoph Sattig
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Patent number: 6957909Abstract: Blister packaging unit (10) for at least two components packed in separate individual packages, at least one of which has a pulverulent or granular consistency, which are to be prepared before use with the further packaged component(s) in a mixer or applicator to form a ready-to-use mixture. The individual packages of the components are inserted in correspondingly pre-shaped receptacles (32; 34) in the blister (30) of a suitable film or other material and this blister is closed on the side of the open mouth of the receptacles by a cover (36) of cardboard, plastic, metal or some other suitable material which may be torn off or opened in some other manner.Type: GrantFiled: July 20, 2000Date of Patent: October 25, 2005Assignee: Smith & Nephew, Inc.Inventors: Elvira Dingeldein, Helmut Wahlig, Christoph Sattig, Edgar Wüst
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Patent number: 6796701Abstract: A preparation and application device for implant materials consisting of at least one powder or granulate component and one liquid component, which are to be prepared immediately before use, is disclosed. The device comprises a first container which holds the powder or granulate component in a sterile, closed-off manner; and a second container which holds the liquid component in a sterile, closed-off manner and which can be connected to the first container. A mixing shaft which is hollow and located on a mixing mechanism is guided out of the first container is hollow and joins a hand pump for producing negative pressure at its external end. A measuring device which indicates the negative pressure can be connected to the first container and the housing of the hand pump is configured in such a way that it is suitable for use as a handle for moving the mixing shaft.Type: GrantFiled: August 20, 2002Date of Patent: September 28, 2004Assignee: Coripharm Medizinprodukte GmbH & Co. KGInventors: Helmut Wahlig, Elvira Dingeldein, Edgar Wüst, Christoph Sattig
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Patent number: 6755563Abstract: The invention relates to a preparation and application device for materials which are to be prepared as a paste-like, flowable mass from at least one powder or granulate component and one liquid component, especially bone cement, with an elongated mixing cylinder for receiving the components to be mixed, comprising in one end region a sealable through-opening that can optionally be provided with a discharge unit for the paste-like material to be prepared, and a piston which can be inserted into the other, opposite, open end. The piston is displaceable in the cylinder and seals against the inner wall of the cylinder. The piston is penetrated by an elongated mixing shaft sealed against the piston, and a mixing mechanism is disposed at the cylinder inside-end of the mixing shaft and a handle disposed at the cylinder outside-end of the mixing shaft.Type: GrantFiled: October 31, 2002Date of Patent: June 29, 2004Assignee: Coripharm Medizinprodukte GmbH & Co. KGInventors: Helmut Wahlig, Elvira Dingeldein, Christoph Sattig, Edgar Wüst
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Patent number: 6689375Abstract: The powdery component of the implant material consists essentially of a mixture of hydroxyl apatite powder and calcium sulfate powder, wherein the hydroxyl apatite powder consists of synthetically prepared, precipitated crystalline nanoparticles of high purity, which have a crystal size of 10-20 nm width and 50-60 nm length. The specific absorbing BET surface area of the nanocrystals is preferably 100-150 m2/g.Type: GrantFiled: June 5, 2002Date of Patent: February 10, 2004Assignee: Coripharm Medizinprodukte GmbH & Co. KGInventors: Helmut Wahlig, Elvira Dingeldein, Edgar Wüst, Christoph Sattig
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Publication number: 20030075564Abstract: The invention relates to a preparation and application device for materials which are to be prepared as a paste-like, flowable mass from at least one powder or granulate component and one liquid component, especially bone cement, with an elongated mixing cylinder for receiving the components to be mixed, comprising in one end region a sealable through-opening that can optionally be provided with a discharge unit for the paste-like material to be prepared, and a piston which can be inserted into the other, opposite, open end. The piston is displaceable in the cylinder and seals against the inner wall of the cylinder. The piston is penetrated by an elongated mixing shaft sealed against the piston, and a mixing mechanism is disposed at the cylinder inside-end of the mixing shaft and a handle disposed at the cylinder outside-end of the mixing shaft.Type: ApplicationFiled: October 31, 2002Publication date: April 24, 2003Inventors: Helmut Wahlig, Elvira Dingeldein, Christoph Sattig, Edgar Wust
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Publication number: 20030021180Abstract: The invention relates to a preparation and application device (10) for implant materials consisting of at least one powder or granulate component and one liquid component, which are to be prepared immediately before use. Said device comprises a first container (12) which holds the powder or granulate component in a sterile, closed-off manner; and a second container (54) which holds the liquid component in a sterile, closed-off manner and which can be connected to the first container (12). Means are provided for producing an overflow connection between the two containers, on a mixing mechanism (30) which is located on a mixing shaft (28) that is guided out of the container in a sealed manner. The first container is configured in such a way that it can he connected to a negative pressure source.Type: ApplicationFiled: August 20, 2002Publication date: January 30, 2003Inventors: Helmut Wahlig, Elvira Dingeldein, Edgar Wust, Christoph Sattig
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Patent number: 6118043Abstract: The invention relates to a bone replacement material which comprises one or more polypeptides having the biological action of fibroblast growth factors in a porous matrix. The healing-in properties correspond to those of autologous bone transplantation.Type: GrantFiled: June 7, 1995Date of Patent: September 12, 2000Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Berthold Nies, Elvira Dingeldein, Helmut Wahlig
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Patent number: 6080801Abstract: A multiple component material, in particular a filler particle containing implantation material is produced and used to anchor prothesis components in bones, to strengthen bones, as dowel for bone screws and as implants for anchoring screws. The polymer component of the disclosed implantation material is preferably based on an acrylate or polymethacrylate basis, or on an acrylate and methacrylate copolymer or a mixture thereof. The polymer component encloses the filler particles at least in part. Preferably, the filler particles are 5 to 15 .mu.m in size and have at least 50% void volume. The multiple component material is stored in a dry, stable particulate form ready for use by mixing with monomer liquid.Type: GrantFiled: July 14, 1998Date of Patent: June 27, 2000Assignee: Klaus DraenertInventors: Klaus Draenert, Helmut Wahlig
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Patent number: 5338772Abstract: The invention relates to an implant material which is based on a composite material of calcium phosphate ceramic particles and bioabsorbable polymer, in which the proportion of calcium phosphate ceramic particles is at least 50% by weight and the particles are joined to one another by polymer bridges to give a three-dimensional open-pore structure in which the particle surfaces are covered with polymer to the extent of not more than 50%. This implant material is distinguished by particularly favorable growing-in and healing-in properties.Type: GrantFiled: June 22, 1992Date of Patent: August 16, 1994Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Hans-Jorg Bauer, Gerd Bauer, Elvira Dingeldein, Helmut Wahlig
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Patent number: 4937257Abstract: New flavanone derivatives of the formula I ##STR1## wherein Ar.sup.1 and Ar.sup.2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen, COOalkyl and/or NO.sub.2 and/or substituted by a methylenedioxy group, and the alkyl, alkoxy and acyl groups each have 1-7 C atoms, but wherein the HO group is only in the 6-position if at least one of the radicals Ar.sup.1 and Ar.sup.2 is substituted phenyl, and the phosphoric acid esters thereof and the salts of these compounds display antiallergic effects. Salts of the I-phosphoric acid esters with aminoglycoside antibiotics are outstandingly stable and possess advantageous kinetics of liberation.Type: GrantFiled: August 28, 1985Date of Patent: June 26, 1990Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rolf Gericke, Helmut Wahlig, Elvira Dingeldein
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Patent number: 4869906Abstract: A resorbable porous tricalcium phosphate, in which the pores are sealed with a filler mixture of an antibiotic and a filler, in particular an amino acid, is particularly advantageous for use in the preparation of bone cements.Type: GrantFiled: April 17, 1987Date of Patent: September 26, 1989Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Elvira Dingeldein, Helmut Wahlig, Manfred Wotschokowsky, Gu Moddelmog
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Patent number: 4853225Abstract: The invention relates to an implantable medicament depot comprising physiologically acceptable excipients and at least one delayed release active compound which is a chemotherapeutic of the gyrase inhibitor type.The depot can be used for combating infections.Type: GrantFiled: December 5, 1986Date of Patent: August 1, 1989Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Helmut Wahlig, Elvira Dingeldein, Johannes Rothe, Wolfgang Stille
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Patent number: 4797282Abstract: A drug depot, which can be implanted in the body, for the controlled, delayed release of cytostatics, comprises a synthetic material based on polyacrylates and/or polymethacrylates containing a cytostatic and at least one amino acid. The depot can be used in a particularly advantageous manner for the local control of tumors.Type: GrantFiled: April 18, 1986Date of Patent: January 10, 1989Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Helmut Wahlig, Elvira Dingeldein
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Patent number: 4632933Abstract: New sulfur-containing imidazole derivatives of the general formula ##STR1## in which Ar is a phenyl radical which is unsubstituted or substituted by one or two halogen atoms, Y is O or S, and Z is a 1-imidazolyl or 2-methyl-1-imidazolyl radical, and their physiologically acceptable acid addition salts, have antimycotic and antibacterial activity.Type: GrantFiled: February 24, 1984Date of Patent: December 30, 1986Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Joachim Gante, Helmut Prucher, Helmut Wahlig, Volkmar Rudolph
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Patent number: 4617293Abstract: Flavonoid phosphates of aminoglycoside antibiotics are useful sparingly soluble salts, e.g., for achieving a depot effect.Type: GrantFiled: May 23, 1984Date of Patent: October 14, 1986Assignee: Merck Patent Gesellschaft mit beschraenkter HaftungInventors: Helmut Wahlig, Elvira Dingeldein, Richard Kirchlechner, Dieter Orth, Werner Rogalski
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Patent number: 4347234Abstract: A shaped mass resorbable in the body, comprises collagen and a bioresorbable binding agent for collagen, the binding agent being selected, e.g., from polymers of C.sub.2-16 .alpha.-hydroxyalkanoic acids, polymers of natural amino acids, hydrolyzed collagen or hydrolyzed elastin.Type: GrantFiled: June 15, 1981Date of Patent: August 31, 1982Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Helmut Wahlig, Elvira Dingeldain, Dietrich Braun
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Patent number: 4291013Abstract: A shaped mass resorbable in the body, comprises collagen and a bioresorbable binding agent for collagen, the binding agent being selected, e.g., from polymers of C.sub.2-16 .alpha.-hydroxyalkanoic acids, polymers of natural amino acids, hydrolyzed collagen or hydrolyzed elastin.Type: GrantFiled: October 9, 1979Date of Patent: September 22, 1981Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Helmut Wahlig, Elvira Dingeldein, Dietrich Braun
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Patent number: 4285961Abstract: Basic thioethers of the formulaR--A--(CH.sub.2).sub.n --Zwherein R is p-R.sup.5 -S-phenyl or 2-dibenzothienyl; A is --CHR.sup.3 --CHR.sup.4 --, --CR.sup.3 (OH)--CHR.sup.4 --, --CHR.sup.3 --CR.sup.4 (OH)-- or --CR.sup.3 .dbd.CR.sup.4 --; Z is --NR.sup.1 R.sup.2, 1-imidazolyl or 1,2,4-triazol-1-yl; n is 1, 2 or 3; R.sup.1 and R.sup.2 are the same or different and each is H, alkyl of 1-4 carbon atoms or together form alkylene of 4-7 ring carbon atoms, or form 3-oxapentamethylene; R.sup.3 and R.sup.4 are the same or different and each is H, alkyl of 1-4 carbon atoms or phenyl; R.sup.5 is an unsubstituted phenyl or benzyl group or a phenyl or benzyl group substituted with 1 or 2 of halogen, nitro, amino and/or alkoxy of 1-4 carbon atoms, alkyl of 1-6 carbon atoms, or cycloalkyl of 3-7 ring carbon atoms, with the proviso that R.sup.5 is alkyl of 1-6 carbon atoms, or cycloalkyl of 3-7 ring carbon atoms when A is --CHR.sup.3 --CH.sub.2 -- and Z is 1-imidazolyl possess valuable pharmacological properties.Type: GrantFiled: October 9, 1979Date of Patent: August 25, 1981Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Helmut Prucher, Jurgen Uhl, Hans-Adolf Kurmeier, Volkmar Rudolph, Helmut Wahlig
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Patent number: 4243810Abstract: Novel pyridone-acetic acid derivative, viz. 3,5-dichloro-4-pyridone-1-acetic acid (I) is used as an intermediate in the production of certain cephem derivatives having anti-bacterial activity against gram-negative and gram-positive bacteria. The acid (I) is prepared by methods generally known in the art, e.g. by reacting 3,5-dichloro-4-pyridone with chloracetic acid or bromoacetic acid.Type: GrantFiled: February 1, 1979Date of Patent: January 6, 1981Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rolf Gericke, Werner Rogalski, Rolf Bergmann, Walter Hameister, Helmut Wahlig