Abstract: The application is directed to polymer coatings which can be modified to control biointerfacial interactions including biofilm formation and protein adsorption onto said coatings. The polymer coatings comprise a First Component comprising epoxide or alkenyl groups, and a Second Component comprising at least one amine group. The polymer coatings further comprise at least one bioactive agent which may control said biofilm formation and/or protein adsorption. Also disclosed herein are methods for producing said coatings incorporating bioactive molecules in one or two step procedures on a substrate. The polymer coating may be immobilised on the substrate via the reaction of functional groups present on the First Component and/or Second Component with complimentary functional groups disposed on at least one surface of the substrate.

Abstract: The application is directed to polymer coatings which can be modified to control biointerfacial interactions including biofilm formation and protein adsorption onto said coatings. The polymer coatings comprise a First Component comprising epoxide or alkenyl groups, and a Second Component comprising at least one amine group. The polymer coatings further comprise at least one bioactive agent which may control said biofilm formation and/or protein adsorption. Also disclosed herein are methods for producing said coatings incorporating bioactive molecules in one or two step procedures on a substrate. The polymer coating may be immobilised on the substrate via the reaction of functional groups present on the First Component and/or Second Component with complimentary functional groups disposed on at least one surface of the substrate.

Abstract: Methods for treating diseased or damaged tissue in a subject are disclosed, involving administering to said subject at a site wherein diseased or damaged tissue occurs, cells of a type(s) normally found in healthy tissue corresponding to the diseased or damaged tissue, and/or suitable progenitor cells thereof, in association with bioresorbable beads or particles and optionally a gel and/or gel-forming substance. Where the cells an/or suitable progenitor cells thereof are chondrocytes, embryonic stem cells and/or bone marrow stromal cells, the methods of the invention are suitable for treating, for example, articular cartilage degeneration associated with primary osteoarthritis.