Patents by Inventor Helmuth H. G. van Es

Helmuth H. G. van Es has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND MEANS FOR TREATMENT OF OSTEOARTHRITIS
    Publication number: 20140107181
    Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject.
    Type: Application
    Filed: October 17, 2013
    Publication date: April 17, 2014
    Applicant: GALAPAGOS N.V.
    Inventors: Nick Vandeghinste, Peter Herwig Maria Tomme, Frits Michiels, Libin Ma, Blandine Mille-Baker, Helmuth H.G. van Es
  • METHOD AND MEANS FOR TREATMENT OF OSTEOARTHRITIS
    Publication number: 20120190727
    Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject.
    Type: Application
    Filed: January 27, 2012
    Publication date: July 26, 2012
    Applicant: GALAPAGOS NV
    Inventors: Nick Vandeghinste, Peter Herwig Maria Tomme, Frits Michiels, Libin Ma, Blandine Mille-Baker, Helmuth H.G. van Es
  • METHOD AND MEANS FOR TREATMENT OF OSTEOARTHRITIS
    Publication number: 20100087514
    Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject.
    Type: Application
    Filed: October 7, 2009
    Publication date: April 8, 2010
    Applicant: Galapagos BV
    Inventors: Nick Vandeghinste, Peter Herwig Maria Tomme, Frits Michiels, Libin Ma, Blandine Mille-Baker, Helmuth H.G. van Es
  • Adenovirus vectors with knobless fibers, and their uses
    Publication number: 20030082146
    Abstract: Novel adenoviral vectors in which the knob of the fiber protein has been removed and replaced with a binding ligand are provided. Further provided are methods of constructing such vectors and uses therefor. A modified knobless adenovirus comprising a new binding ligand according to the invention has improved capabilities of entry into specific cell types.
    Type: Application
    Filed: October 28, 2002
    Publication date: May 1, 2003
    Inventors: Helmuth H. G. van Es, Victor W. van Beusechem
  • Swap/counter selection: a rapid cloning method
    Publication number: 20020177229
    Abstract: A method for transferring a polynucleic acid sequence from a donor vector to an acceptor vector wherein said donor vector includes a first antibiotic resistance functioning sequence (ARFS) and said acceptor vector includes a second ARFS comprising:
    Type: Application
    Filed: January 18, 2002
    Publication date: November 28, 2002
    Inventors: Ivo Piest, Godefridus A.M. Michiels, Helmuth H.G. van Es, Onno van de Stolpe
  • High throughput screening of gene function using adenoviral libraries for functional genomics applications
    Patent number: 6413776
    Abstract: Novel adenovirus vectors and methods for their use are provided to determine the function of the product(s) of one or more sample nucleic acids. The sample nucleic acids are synthetic oligonucleotides, DNA, or cDNA and encode polypeptides, antisense nucleic acids or GSEs. The sample nucleic acids are expressed in a host by recombinant adenovirus vectors to alter at least one phenotype of the host. The altered phenotype(s) is identified as a means to assign a biological function to the product(s) encoded by the sample nucleic acid(s).
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: July 2, 2002
    Assignee: Galapagos Geonomics N.V.
    Inventors: Ronald Vogels, Abraham Bout, Helmuth H. G. van Es, Govert Shouten