Patents by Inventor Hemaka A. Rajapakse

Hemaka A. Rajapakse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4,6-Substituted Pyridyl Derivative Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
    Publication number: 20080015233
    Abstract: The present invention is directed to 2,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: April 20, 2005
    Publication date: January 17, 2008
    Inventors: James Barrow, Georgia McGaughey, Philippe Nantermet, Hemaka Rajapakse, Harold Selnick, Shaun Stauffer, Joseph Vacca, Shawn Stachel, Craig Coburn, Matthew Stanton
  • 2,3,4,6-Substituted Pyridyl Derivative Compounds Useful As Beta-Secretase Inhibitors For The Treatment Of Alzheimer's Disease
    Publication number: 20070293497
    Abstract: The present invention is directed to 2,3,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: November 18, 2005
    Publication date: December 20, 2007
    Inventors: Philippe Nantermet, Hemaka Rajapakse, Harold Selnick, James Barrow, Shaun Stauffer, Joseph Vacca, Keith Moore, Shawn Stachel, Mattahew Stanton
  • 1,3,5-Substituted Phenyl Derivative Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
    Publication number: 20070244119
    Abstract: The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: April 15, 2005
    Publication date: October 18, 2007
    Inventors: James Barrow, Georgia McGaughey, Philippe Nantermet, Hemaka Rajapakse, Harold Selnick, Shaun Stauffer, Craig Coburn
  • Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
    Publication number: 20070088165
    Abstract: The present invention is directed to benzylether and benzylamino derivative compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: November 19, 2004
    Publication date: April 19, 2007
    Inventors: Philippe Nantermet, Hemaka Rajapakse, Harold Selnick, Shaun Stauffer, Mary Beth Young
  • Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
    Publication number: 20070021454
    Abstract: The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: July 14, 2006
    Publication date: January 25, 2007
    Inventors: Craig Coburn, Melissa Egbertson, Samuel Graham, Georgia McGaughey, Shaun Stauffer, Hemaka Rajapakse, Philippe Nantermet, Shawn Stachel, Wenjin Yang, Wanli Lu, Bruce Fahr
  • Benzylether and benzylamino beta-secretase inhibitors for the treatment of alzheimer's disease
    Publication number: 20060293380
    Abstract: The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: September 29, 2004
    Publication date: December 28, 2006
    Inventors: Philippe Nantermet, Hemaka Rajapakse, Harold Selnick
  • Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease
    Publication number: 20060149092
    Abstract: The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
    Type: Application
    Filed: June 25, 2004
    Publication date: July 6, 2006
    Inventors: Philippe Nantermet, Hemaka Rajapakse, Harold Selnick