Abstract: The present invention proposes a formulation and the process to prepare thick water to be administered to patients afflicted by dysphagia. It particularly comprises of a polymer that helps the formulation to stay thick when administered and thins out as it passes to the stomach. The formulation does not regain viscosity when it enters duodenum and small intestine regions. This formulation for the management of dysphagia can be prepared at any consistency/viscosity required. Some of the advantages proposed are a decrease in feeling of satiety, ease of administration and no effect on the bioavailability of co-administered medications.

Abstract: A combination oral liquid formulation of melatonin with a antihistaminic drug has been proposed as a sleep-aid agent. The solubility and stability of melatonin was improved by using cyclodextrin and adjusting the pH to a suitable value. The combination drug is expected to have a dual mode of action. The antihistaminic agent may help patient to fall asleep quickly and melatonin may be effective subsequently providing a sound sleep to the patient.

Abstract: Ferrous sulfate and ferrous ammonium sulfate are known to kill moss and liverwort. They impart acidity in the lawn. Moss grows better in an acidic pH. The current invention proposes a formulation of ferrous sulfate or ferrous ammonium sulfate and zero valent iron with lime. Lime neutralizes the acidity produced by the ferrous salt and keeps the pH of the soil at 7 to 7.5. The formulation produces an immediate effect to eradicate moss and also provides a sustained effect over a long period. Another embodiment contains an addition of antimicrobial agents such as benzalkonium chloride, dichlorophen, and didecyldimethyl ammonium chloride to the ferrous sulfate-lime formulation.

Abstract: The present invention claims the usage of coating technology to produce multi-segmented pharmaceutical dosage forms for a combination drug therapy. The core matrix containing a drug is coated with drug containing solutions or suspensions. The separation of different drugs in the core and various coating segments prevents drug-drug interaction and improve drug stability, provide desired release rates for different drugs in the dosage form. The dosage form may release drugs in different parts of the gastrointestinal tract.

Abstract: The crystalline, stable methanesulfonate salt of nefazodone showed significantly higher intrinsic dissolution in water and THAM buffer (pH 7.5) compared to other salts of nefazodone. The faster dissolution rate of this salt at neutral pH suggests better dissolution and absorption in the intestine, allowing controlled release of nefazodone for oral formulations.