Patents by Inventor Hemayet Ullah

Hemayet Ullah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11737462
    Abstract: Compounds and methods are described herein that are effective to modulate plant response (e.g., plant susceptibility) to environmentally-induced stress. The compounds and methods described herein advantageously may be used to modulate environmental stress resistance in a wide variety of plants. Environmental stresses include, for example, high light intensity (UV exposure), temperature (e.g., high heat), high soil salinity, and low soil moisture (e.g., drought). As used herein, environmental stresses include any conditions that result in increased generation of reactive oxygen species (ROS) and accumulation of ROS in the plant cells. The compounds described herein that are effective to modulate resistance to the stress prevent, directly or indirectly, or increase phosphorylation of Tyr248 of the RACK1A protein.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: August 29, 2023
    Assignees: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITY
    Inventors: Sivanesan Dakshanamurthy, Hemayet Ullah
  • Publication number: 20230183703
    Abstract: The present disclosure provides compositions and methods for treating and detecting coronavirus infection, and in particular embodiments, provides compositions and methods for treating and detecting SARS-CoV-2 infection. The present disclosure also relates to the production of compositions for treating and detecting coronavirus infection, and in particular embodiments, to the production of compositions for treating and detecting SARS-CoV-2 infection.
    Type: Application
    Filed: May 14, 2021
    Publication date: June 15, 2023
    Applicant: HOWARD UNIVERSITY
    Inventor: Hemayet ULLAH
  • Patent number: 11596623
    Abstract: A method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site-utilizing virus (IRES-utilizing virus) involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: March 7, 2023
    Assignees: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITY
    Inventors: Hemayet Ullah, Sivanesan Dakshanamurthy
  • Patent number: 11576901
    Abstract: A method effective in treating a viral infection involves administering a therapeutically effective amount of at least one compound capable of inhibiting expression of at least a portion of a virus genome containing an internal ribosomal entry site, or a pharmaceutically acceptable salt thereof. The compound has an azole moiety comprising a five member heterocyclic ring containing at least one nitrogen atom, a hydrophobic moiety bonded to the heterocyclic ring of the azole, and a donor/acceptor moiety bonded to the heterocyclic ring having at least one of hydrogen bond donor and a hydrogen bond acceptor.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: February 14, 2023
    Assignees: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITY
    Inventors: Hemayet Ullah, Sivanesan Dakshanamurthy
  • Publication number: 20220211673
    Abstract: A combinatorial method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site utilizing virus (IRES-utilizing virus) in a host in need of treatment involves administering the host a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo; and either separately administering another anti-viral drug and/or pro-drug to the anti-viral drug or co-administering the anti-viral drug and/or the pro-drug with the compound, its tautomer, or its pharmaceutically acceptable salt.
    Type: Application
    Filed: April 27, 2020
    Publication date: July 7, 2022
    Applicants: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITY
    Inventors: Hemayet ULLAH, Sivanesan DAKSHANAMURTHY
  • Publication number: 20220168277
    Abstract: A method for treating against, or at least inhibiting or suppressing, the proliferation of a cancer involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting metastasis of cancer cells, wherein the compound is represented by the formula (1): wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.
    Type: Application
    Filed: March 25, 2020
    Publication date: June 2, 2022
    Applicants: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITY
    Inventors: Hemayet ULLAH, Sivanesan DAKSHANAMURTHY
  • Publication number: 20220096442
    Abstract: A method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site-utilizing virus (IRES-utilizing virus) involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.
    Type: Application
    Filed: October 29, 2019
    Publication date: March 31, 2022
    Applicants: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITY
    Inventors: Hemayet ULLAH, Sivanesan DAKSHANAMURTHY
  • Publication number: 20200297699
    Abstract: A method effective in treating a viral infection involves administering a therapeutically effective amount of at least one compound capable of inhibiting expression of at least a portion of a virus genome containing an internal ribosomal entry site, or a pharmaceutically acceptable salt thereof. The compound has an azole moiety comprising a five member heterocyclic ring containing at least one nitrogen atom, a hydrophobic moiety bonded to the heterocyclic ring of the azole, and a donor/acceptor moiety bonded to the heterocyclic ring having at least one of hydrogen bond donor and a hydrogen bond acceptor.
    Type: Application
    Filed: March 27, 2017
    Publication date: September 24, 2020
    Inventors: Hemayet ULLAH, Sivanesan DAKSHANAMURTHY
  • Publication number: 20180360043
    Abstract: Compounds and methods are described herein that are effective to modulate plant response (e.g., plant susceptibility) to environmentally-induced stress. The compounds and methods described herein advantageously may be used to modulate environmental stress resistance in a wide variety of plants. Environmental stresses include, for example, high light intensity (UV exposure), temperature (e.g., high heat), high soil salinity, and low soil moisture (e.g., drought). As used herein, environmental stresses include any conditions that result in increased generation of reactive oxygen species (ROS) and accumulation of ROS in the plant cells. The compounds described herein that are effective to modulate resistance to the stress prevent, directly or indirectly, or increase phosphorylation of Tyr248 of the RACK1A protein.
    Type: Application
    Filed: September 5, 2018
    Publication date: December 20, 2018
    Inventors: Sivanesan Dakshanamurthy, Hemayet Ullah
  • Publication number: 20150119250
    Abstract: Compounds and methods are described herein that are effective to modulate plant response (e.g., plant susceptibility) to environmentally-induced stress. The compounds and methods described herein advantageously may be used to modulate environmental stress resistance in a wide variety of plants. Environmental stresses include, for example, high light intensity (UV exposure), temperature (e.g., high heat), high soil salinity, and low soil moisture (e.g., drought). As used herein, environmental stresses include any conditions that result in increased generation of reactive oxygen species (ROS) and accumulation of ROS in the plant cells. The compounds described herein that are effective to modulate resistance to the stress prevent, directly or indirectly, or increase phosphorylation of Tyr248 of the RACK1A protein.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 30, 2015
    Inventors: Sivanesan Dakshanamurthy, Hemayet Ullah
  • Publication number: 20040187176
    Abstract: The invention provides methods for improving plant agronomic traits by altering the expression or activity of plant G-protein alpha and beta subunits that are GPA1 or AGB1 orthologs. The invention also provides such transgenic plants with improved agronomic traits. One embodiment of the invention includes methods for modulating the expression or activity of a plant G-protein beta subunit that is an AGB1 ortholog to alter one or more of the following: the time to reach and duration of flowering, fruit yield, root biomass, seed size, seed shape, plant size, and the number of stem branches. The present invention also encompasses methods for modulating the expression or activity of a plant G-protein alpha subunit that is a GPA1 ortholog to alter one or more of the following: the duration of flowering, fruit and seed yield, plant size, seed size, and seed shape.
    Type: Application
    Filed: June 24, 2003
    Publication date: September 23, 2004
    Inventors: Douglas Boyes, Keith Davis, Alan Jones, Hemayet Ullah, Jin-Gui Chen, Rao Mulpuri, Ani Chatterjee, Mary P. Ward