Patents by Inventor Heming Wei

Heming Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12282261
    Abstract: Methods of fabricating an object via direct laser lithography are provided. In embodiments, such a method comprises illuminating, via an optical fiber having an end facet and a metalens directly on the end facet, a location within a photosensitive composition from which an object is to be fabricated with light, thereby inducing a multiphoton process within the photosensitive composition to generate a region of the object; and repeating the illuminating step one or more additional times at one or more additional locations to generate one or more additional regions of the object.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: April 22, 2025
    Assignee: Northwestern University
    Inventors: Sridhar Krishnaswamy, Heming Wei, Wisnu Hadibrata, Koray Aydin
  • Patent number: 12257079
    Abstract: An intraocular pressure (IOP) includes a transmission film component, which is in direct contact with intraocular aqueous humor and configured to sense pressure fluctuations in the intraocular aqueous humor; a reflective film component set on an inner side of the transmission film component; and an adhesion layer component set on an inner layer of the reflective film component and configured to connect to an attachment device. An enclosed space formed by the reflective film component and the transmission film component constitutes a resonance chamber, which is filled with a filling medium. When a pressure in the intraocular aqueous humor is changed, the transmission film component is deformed, resulting in a change in a near-infrared (NIR) spectrum reflected by the reflective film component; the IOP is detected according to the change of the NIR spectrum.
    Type: Grant
    Filed: October 21, 2022
    Date of Patent: March 25, 2025
    Assignee: MINGCHE BIOTECHNOLOGY CO., LTD
    Inventors: Dongni Ren, Fule Wang, Kemin Wang, Ruixue Yin, Heming Wei, Hongbo Zhang
  • Publication number: 20230337983
    Abstract: An intraocular pressure (IOP) includes a transmission film component, which is in direct contact with intraocular aqueous humor and configured to sense pressure fluctuations in the intraocular aqueous humor; a reflective film component set on an inner side of the transmission film component; and an adhesion layer component set on an inner layer of the reflective film component and configured to connect to an attachment device. An enclosed space formed by the reflective film component and the transmission film component constitutes a resonance chamber, which is filled with a filling medium. When a pressure in the intraocular aqueous humor is changed, the transmission film component is deformed, resulting in a change in a near-infrared (NIR) spectrum reflected by the reflective film component; the TOP is detected according to the change of the NIR spectrum.
    Type: Application
    Filed: October 21, 2022
    Publication date: October 26, 2023
    Inventors: Dongni REN, Fule WANG, Kemin WANG, Ruixue YIN, Heming WEI, Hongbo ZHANG
  • Publication number: 20220171293
    Abstract: Methods of fabricating an object via direct laser lithography are provided. In embodiments, such a method comprises illuminating, via an optical fiber having an end facet and a metalens directly on the end facet, a location within a photosensitive composition from which an object is to be fabricated with light, thereby inducing a multiphoton process within the photosensitive composition to generate a region of the object; and repeating the illuminating step one or more additional times at one or more additional locations to generate one or more additional regions of the object.
    Type: Application
    Filed: November 1, 2021
    Publication date: June 2, 2022
    Inventors: Sridhar Krishnaswamy, Heming Wei, Wisnu Hadibrata, Koray Aydin
  • Publication number: 20190084241
    Abstract: A multiscale multiphoton photolithography system for fabricating a 3D object may comprise a support structure configured to support a light-sensitive composition from which the 3D object is to be fabricated; a microscope objective configured to focus light on the light-sensitive composition via an optical path; a first optical assembly configured to provide light of a first wavelength to the microscope objective, the first wavelength selected to induce a single photon process in the light-sensitive composition; a second optical assembly configured to provide light of a second wavelength to the microscope objective, the second wavelength selected to induce a multiphoton process in the light-sensitive composition; and a controller operably coupled to the first and second optical assemblies.
    Type: Application
    Filed: September 20, 2018
    Publication date: March 21, 2019
    Inventors: Sridhar Krishnaswamy, Heming Wei
  • Patent number: 9598675
    Abstract: The present invention provides a method for preparing mesenchymal stem cell-like cells and cardiomyocyte-like cells from induced pluripotent stem cells. With the method, embryoid bodies are first formed from induced pluripotent stem cells in a non-adherent substrate. The embryoid bodies are then contacted with a serum-free and insulin-free medium comprising a p38-MAPK inhibitor to form aggregates of contracting embryoid bodies. The contracting embryoid body aggregate(s) are then induced to form mesenchymal stem-cell-like cells and aggregates of cardiomyocyte-like stem cells with a medium comprising ?5% serum in a cell-culture treated substrate. The cardiomyocyte-like cells and the mesenchymal stem-cell like cells may be separated to give isolated populations of each cell type. The population of cardiomyocyte-like cells and mesenchymal stem-cell like cells and the isolated population of each cell type may be used for replacing cells.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: March 21, 2017
    Assignee: SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Winston Se Ngie Shim, Heming Wei
  • Publication number: 20140314725
    Abstract: The present invention provides a method for preparing mesenchymal stem cell-like cells and cardiomyocyte-like cells from induced pluripotent stem cells. With the method, embryoid bodies are first formed from induced pluripotent stem cells in a non-adherent substrate. The embryoid bodies are then contacted with a serum-free and insulin-free medium comprising a p38-MAPK inhibitor to form aggregates of contracting embryoid bodies. The contracting embryoid body aggregate(s) are then induced to form mesenchymal stem-cell-like cells and aggregates of cardiomyocyte-like stem cells with a medium comprising ?5% serum in a cell-culture treated substrate. The cardiomyocyte-like cells and the mesenchymal stem-cell like cells may be separated to give isolated populations of each cell type. The population of cardiomyocyte-like cells and mesenchymal stem-cell like cells and the isolated population of each cell type may be used for replacing cells.
    Type: Application
    Filed: October 12, 2012
    Publication date: October 23, 2014
    Applicant: SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Winston Se Ngie Shim, Heming Wei
  • Publication number: 20090215171
    Abstract: An isolated polynucleotide coding for platelet endothelial cell adhesion molecule-1 (PECAM-1), and obtainable by amplifying cDNA from total human white blood cells by PCR; peptides encoding PECAM-1 5th Ig-like domain; an antibody against one of the peptides; associated compositions methods and kits of parts.
    Type: Application
    Filed: December 19, 2008
    Publication date: August 27, 2009
    Applicant: The Johns Hopkins University
    Inventors: Subroto Chatterjee, Heming Wei
  • Publication number: 20060127921
    Abstract: An isolated polynucleotide coding for platelet endothelial cell adhesion molecule-1 (PECAM-1), and obtainable by amplifying cDNA from total human white blood cells by PCR; peptides encoding PECAM-1 5th Ig-like domain; an antibody against one of the peptides; associated compositions methods and kits of parts.
    Type: Application
    Filed: June 21, 2005
    Publication date: June 15, 2006
    Inventors: Subroto Chatterjee, Heming Wei