Abstract: A technical solution is directed to a clock recovery apparatus for multi-level signaling on a single-lane communication interface. The apparatus can use bin-map logic to successfully recover a common clock per symbol received on the multi-level signal interface. The multi-level signal can be PAM4 signaling where two bits are encoded to represent four levels. The clock recovery apparatus can detect signal level through individual edge detectors for each of the two bits and can handle jitter up to half-clock period.

Abstract: A method can include obtaining, at a physical communication layer integrated with a communication interface, a data packet, detecting, by a detection circuit integrated with the physical communication layer, a portion of data in the data packet corresponding to a marker identifying the data packet, linking, by the physical communication layer based on the marker, a timestamp with the data packet, and transmitting, by the physical communication layer, the data packet linked with the timestamp.

Abstract: Timing constraint auto-creation for integrated circuit testing includes analyzing an integrated circuit design using a first clocking attribute, wherein the first clocking attribute describes a first clock for the integrated circuit design; identifying, based on the analysis and the first clocking attribute, design features of the integrated circuit design necessitating timing constraints; and generating, based on the identified design features, the timing constraints for the static timing analysis of the integrated circuit design.

Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Abstract: The present disclosure describes systems and methods for performing timing analysis of circuit designs. According to an embodiment, a method includes assigning a timing margin to a non-scan latch of a circuit design and performing a timing analysis on the circuit design using the timing margin for the non-scan latch to produce timing results for the circuit design. The timing results include a slack value. The method also includes calculating a credit based on the slack value and updating the slack value based on the credit.

Abstract: Timing analysis of a digital integrated circuit using intent based timing constraints includes defining a plurality of intent groups for an integrated circuit design. Each intent group is associated with a different clock type of the integrated circuit design. A different timing phase of a plurality of timing phases of one or more clock signals of the integrated circuit design is associated with each intent group. One or more timing constraints is associated with each of the intent groups. A timing result is computed based on propagating the timing phases of each of the intent groups and applying the associated timing constraints from an input to a timing point of the integrated circuit design.

Abstract: Timing analysis of a digital integrated circuit includes determining an initial delay value for a gate of an integrated circuit design. The gate is located within a predefined area of the integrated circuit design. A first scale factor is calculated based on a number of switching transistors within the predefined area, and a second scale factor is calculated based on a voltage drop value associated with the predefined area. An updated delay value for the gate is calculated based on the initial delay value, the first scale factor, and the second scale factor.

Abstract: The present disclosure provides methods, systems, and media for optimized customer relationship management. A method for identifying subjects for a clinical procedure may comprise (a) retrieving, from a computer database, a first set of subject records, wherein the first set of subject records corresponds to a first set of subjects that are candidates for the clinical procedure; (b) processing the first set of subject records using a trained machine learning algorithm to generate a second set of subject records; and (c) electronically outputting the second set of subject records.

Abstract: A cooking appliance comprises an outer frame surface defining a cooktop and the cooktop defines an outlet port. An inner frame surface defines a heating cavity disposed below the cooktop and within the outer frame surface. The inner frame surface defines an inlet port and a chimney extends between a first end connected to the inlet port and a second end connected to the outlet port for directing steam from the heating cavity outside of the cooking appliance. A nozzle apparatus is connected around the outlet port and includes an inner wall defining at least one aperture. The at least one aperture is oriented at an acute angle relative to the cooktop. The nozzle apparatus includes at least one post for connection to the cooktop.

Abstract: Provided herein are populations of placental-derived natural killer cells comprising a cleavage resistant CD16. Also provided are methods of treating diseases, disorders or conditions in a human subject comprising administering to the subject an effective amount of a population of placental-derived natural killer cells comprising a cleavage resistant CD16 to the subject so as thereby to provide an effective treatment of the to the subject. The cells, such as CYNK cells, can be placental CD34+ cell-derived natural killer (NK) cells. The diseases, disorders or conditions include cancers such as multiple myeloma and lymphoma. The present invention also provides compositions comprising populations of placental-derived natural killer cells comprising a cleavage resistant CD16 for the treatment of a subject and methods of their use.

Abstract: A system, method, and computer program product for setting an employee contribution to a retirement plan are disclosed. The method includes: assigning, by a computer system, each employee in a plurality of employees to one of a plurality of clusters by processing socio-economic information for the plurality of employees using machine learning to generate a machine learning model; determining, by the computer system, a benchmark for each cluster in the plurality of clusters from a characteristic of contributions to a retirement plan of the employees assigned to the cluster; identifying, by the computer system, a selected cluster in the plurality of clusters for a selected employee using the machine learning model; and controlling displaying, by a graphical user interface, the benchmark for the selected cluster to the selected employee.

Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Abstract: Provided herein are methods of treating cancer in a human subject comprising administering to the subject an effective amount of human placental-derived natural killer cells comprising a CD38 chimeric antigen receptor (CAR) to the subject so as thereby to provide an effective treatment of the cancer in the subject. The cells, such as CYNK cells, can be placental CD34+ cell-derived natural killer (NK) cells. The cancers to be treated include multiple myeloma and lymphoma. The present invention also provides compositions comprising human placental-derived natural killer cells comprising a CD38 chimeric antigen receptor (CAR) or the treatment of multiple myeloma and lymphoma and methods of their use.

Abstract: The present invention relates to a stable liquid pharmaceutical composition of pemetrexed for parenteral administration. The invention provides composition comprising pemetrexed diacid, an organic amine and cyclodextrin. The composition may further comprise an inert gas. The composition can be ready to use infusion solution of pemetrexed diacid or liquid concentrate formulation to be diluted before administration to the patient. The present invention further relates to a process for manufacturing the compositions as well as use of the compositions of the invention for the treatment of malignant pleural mesothelioma and non-small cell lung cancer.

Abstract: A diabetes management system includes a handheld medical device, a mobile computing device, and a diabetes management application. The handheld medical device is configured to measure glucose in a sample of fluid residing in a test strip and associate a measurement time with the glucose measurement. The diabetes management application is configured to request a current device time from the RTC, determine a first device delta time by determining a difference between the current device time and an internal clock time, and associate a first timestamp with a glucose measurement, wherein the first timestamp is equal to the measurement time plus the first device delta time.

Abstract: Provided herein are stimulated placental stem cells and methods of treating individuals having diseases or disorders of the circulatory system using stimulated placental cells. The invention also provides methods of inducing angiogenesis using such stimulated cells or populations of cells comprising such stimulated cells.

Abstract: A video player that can launch a program from the video player while a video relating to the program (for example, a tutorial video) is being played. Also, a video player that can start a video location at a time location that is determined by a program location currently being executed by a computer program being run by the user. In order to do these things, a mapping is maintained between time ranges in the video and program locations to which the time ranges of the video respectively relate.

Abstract: To increase the efficiency of electronic design automation, in a putative electronic logic circuit design, at least one transparent latch is identified as a candidate for slack stealing. An initial timing slack, available for stealing, and associated with the at least one transparent latch, is determined. Responsive to a determination that the initial timing slack available for stealing is insufficient, it is determined whether the initial timing slack available for stealing is on a feedback path. If so, responsive to determining that the initial timing slack available for stealing is on the feedback path, the initial timing slack available for stealing is replaced with a next worse slack.

Abstract: To increase the efficiency of electronic design automation, in a putative electronic logic circuit design, at least one transparent latch is identified as a candidate for slack stealing. An initial timing slack, available for stealing, and associated with the at least one transparent latch, is determined. Responsive to a determination that the initial timing slack available for stealing is insufficient, it is determined whether the initial timing slack available for stealing is on a feedback path. If so, responsive to determining that the initial timing slack available for stealing is on the feedback path, the initial timing slack available for stealing is replaced with a next worse slack.