Abstract: This invention relates to the field of therapeutic agents for the treatment of Age-Associated Memory Impairment (AAMI). In particular, the present invention utilizes compositions comprising at least one compound capable of elevating ketone body concentrations in a mammal (e.g., ketogenic compounds), administered in an amount effective for treatment or prevention of loss of cognitive function caused by reduced neuronal metabolism in AAMI. In one embodiment, the composition includes medium chain triglycerides (MCT). In another embodiment, the compositions are administered in the presence of carbohydrate. The present invention also relates to oral dosage forms, in particular, a nutritional drink comprising at least one compound capable of elevating ketone body concentrations in a mammal.

Abstract: Antennas with steerable antenna patterns and techniques for using such antennas are described. In accordance with the invention, antenna patterns with one or more NULLs are used. Through the use of digital control signals the antenna pattern is steered so that a source of signal interference, e.g., a multipath signal, will be located in a NULL. In this manner the received signal's S/N ratio can be maximized thereby facilitating demodulation. The techniques of the invention can be applied to television, computer devices, mobile devices and a wide range of other systems. Digital commands to control an antenna may include multiple information fields, e.g., a direction field, a channel field, a gain field and a polarity field. Antennas incapable of supporting the specified fields disregard information in fields which are not supported. Information in each supported field is decoded and used to adjust the corresponding antenna characteristic.

Abstract: The system is a distributed video transcoding system that allows content to be transformed from one digital format to another close to the ingest and delivery points to minimize the time and cost of the transfer between end points. Additionally by making transcoding an integral part of the distribution of content itself, significant efficiencies can be gained. The distribution can be improved by transcoding at different phases of the transfer. Within the system decisions can be made to utilize different transcoding resources based on various business rules and priorities.

Abstract: An interlock system for use with casing running tools including, without limitation, casing running tools utilized with rig top drive systems. A pressure circuit is in communication with casing running tool slips and spider assembly slips. The pressure circuit controls the supply of pressure to: (1) release the spider slips only when the casing running tool slips are engaged and supporting the entire pipe string; and (2) release the casing running tool slips only when the spider slips are engaged and supporting the entire pipe string.

Abstract: The present invention describes an implantable tissue lifting and fixation device. More particularly, the present invention describes a temporal brow lifting device comprised of a bio-absorbable supportive backing. The device has a shape of a curvilinear end and a tail end region. The curvilinear end region comprises a plurality of attachment points protruding from the supportive backing, and the tail region comprises of a plurality of cavities in order to secure the device at the desired elevated position in the deep temporal fascia. The plurality of attachment points distributes tension in a multi-vector direction over the contact area between the device and the tissue. The attachment points can be manufactured separately and attached, however, preferably, the attachment points are made integral with the temporal brow lifting device.

Abstract: Benzodiazepine derivative of formula (I), and pharmaceutically acceptable salts thereof, are found to be active against RSV Formula (I) Wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6 alkyl; -each R3 is the same or different and represents halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio C1-6 haloalkyl, C1-6 haloalkoxy, amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, nitro, cyano, —CO2R?, CONR?R?, —NH—CO—R?, —S(O)R?, —S(O)2R?, —NH—S(O)2R?, —S(O)NR?R? or —S(O)2NR?R? wherein each R? and R? is the same or different and represents hydrogen or C1-6 alkyl; -n is from 0 to 3; R4 represents hydrogen or C1-6 alkyl; —R6 represents C1-6 alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-C(O)—C(O)—, heteroaryl-C(O)—C(O)—, carbocyclyl-C(O)—C(O)—, heterocyclyl-C(O)—C(O)— or, —XR6; —X represents —CO—, —S(O)— or —S(0)2—; and —R6 represents C1-6 alkyl, hydroxy, C1-6 alk

Abstract: The present invention involves the production of a fabric having double-sided encapsulation and a film overlaid on each side. In some embodiments, the fabric is a composite article that possesses low or a lack of air permeability, is light in weight, is flexible, and can be sewn in one web. Applications for such composite articles can range from entertainment devices such as inflatable toys to emergency devices such as airbags, inflatable rafts, aircraft emergency escape slides, various safety gear, and jump cushions commonly used by firefighters.

Abstract: A variable geometry turbocharger is simplified yet able to maintain pulse energy. In a first embodiment, a turbine housing is provided with a pivoting wall which pivots about a point near the entry to the turbine housing. By moving the wall about the pivot point, the effective volume of the turbine housing volute is varied, thus effectively reducing the volume of exhaust gas in the volute, allowing control of exhaust gas flowing to the turbine wheel. In the second embodiment of the invention, a rotating wedge segment within the volute is rotated from a first position to a second position, changing the effective volume of the volute and allowing control of exhaust gas flowing to the turbine wheel.

Abstract: The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K?. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: A laser woodworking machine for cutting wood is disclosed. The machine includes a laser cutting head having two sections structurally configured to include sensors for measurements of depth and of reflected frequencies, a laser unit for supplying power to the laser cutting head, a cabinet enclosure for housing the laser unit and including a table surface, a radial arm supported by a column secured to the inside rear portion of the cabinet enclosure and including a pair of radial supports extending perpendicularly from opposite sides of the column and parallel to each other, and a glider carriage secured to the radial supports and including two substantially flat surfaces above and below the radial supports so that the glider carriage slides along the radial supports via sleeves, the glider carriage further comprising support for the laser cutting head so that the laser cutting head is moveable along the radial arm.

Abstract: A method for manufacturing a semiconductor device includes fabricating an active layer on a first side of a semiconductor substrate. The method also includes fabricating a metal layer on a second side of the semiconductor substrate. The metal layer includes a passive device embedded within the metal layer. The passive device can electrically couple to the active layer with through vias.

Abstract: There is disclosed various embodiments of an implantable anchor for permanently anchoring a medical lead or catheter. For instance, there is disclosed an implantable anchor including a body having a longitudinal lumen defined therein, wherein the longitudinal lumen is sized to accept a portion of the medical lead or catheter, a bending mechanism coupled to the body for bending the lead to a predetermined angle within the body, and a retaining mechanism for maintaining the predetermined angle of the bent lead within the body.

Abstract: In a direct electron detector, backscattering of electrons into the detector volume from below the sensor is prevented. In some embodiments, an empty space is maintained below the sensor. In other embodiments, a structure below the sensor includes geometry, such as multiple high aspects ratio channels, either extending to or from the sensor to trap electrons, or a structure of angled surfaces to deflect the electrons that pass through the sensor.

Abstract: An adhesive label includes a polymeric first film layer that has an affinity for water. The label is useful in various labeling applications and especially adhesive labeling of reusable and recyclable containers which require removal of the label during a washing process in a warm or hot washing fluid.

Abstract: A respiratory mask (10) that comprises a mask body (12) and a harness (21) that includes a carriage (22) and a strap (24). The mask body (12) lacks a rigid insert, is non-elastomeric, and is adapted for fitting over a person's nose and mouth. The mask body (12) has a nose portion (14), a chin portion (16), first and second cheek portions (18 and 20), and an axis (32) that extends from the nose portion (14) to the chin portion (16). The mask body (12) is constructed to deform such that the first and second cheek portions (18 and 20) move towards each other about the axis (32). The carriage (22) is joined to the mask body (12), and the strap (24) is joined to the carriage (22) for supporting the mask body (12) over a person's nose and mouth. When tension is applied to the strap (24) and an opposing force acts at the nose and chin portions of the mask body, the first and second cheek portions (18, 20) exhibit movement about the axis (32) towards each other.

Abstract: A disposable roof covering comprising a plastic substrate having a porous top surface, and a superabsorbent polymer located between the top surface and bottom surface of the substrate. The polymer absorbs water contacting the roof covering and allows it to evaporate over time to cool the roof structure and interior of the building. The invention provides a lightweight, low cost roof covering for cooling buildings. A method for cooling a roof structure by applying the disposable roof covering over the roof structure is also provided.

Abstract: In one embodiment, the present invention includes a method for the synthesis of an ester derivative of acetoacetate. The method includes providing a first ester of acetoacetate and providing an alcohol. The method further includes combining the first ester of acetoacetate and the alcohol in the presence of an enzyme capable of transesterification in a non-aqueous solvent to form the ester derivative of acetoacetate. The method results in the formation of the ester derivative of acetoacetate, which, in one embodiment, is monoacetoacetin.

Abstract: A polymeric film for labeling articles comprises an asymmetric multilayered film comprising specialized skin and core layers whose compositions address multiple needs including adhesion of a printing ink and an adhesive and die-cuttability. The polymeric film provides improved performance in the conversion to an adhesive containing label stock and adhesive label.

Abstract: A ballistic transfer delay device and method of use. The ballistic transfer delay device does not include a firing pin and it is not pressure initiated. The device comprises a time delay fuse, a through-bulkhead initiator to initiate the time delay fuse, and an output booster to ballistically transfer the energy from the initiated time delay fuse.