Patents by Inventor Hendrick Bothmann

Hendrick Bothmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of ?7 nicotinic acetylcholine receptors and therapeutic uses thereof
    Patent number: 8163729
    Abstract: The present invention provides compounds of formula (I) and compositions thereof, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.
    Type: Grant
    Filed: January 16, 2008
    Date of Patent: April 24, 2012
    Assignees: Wyeth, Siena Biotech S.p.A.
    Inventors: Chiara Ghiron, Arianna Nencini, Iolanda Micco, Riccardo Zanaletti, Laura Maccari, Hendrick Bothmann, Simon N. Haydar, Maurizio Varrone, Carmela Pratelli, Boyd L. Harrison
  • ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS
    Publication number: 20100130474
    Abstract: The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate ?7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory systems.
    Type: Application
    Filed: July 16, 2009
    Publication date: May 27, 2010
    Applicants: WYETH, SIENA BIOTECH S.P.A.
    Inventors: Hendrick Bothmann, Chiara Ghiron, Laura Maccari, Iolanda Micco, Arianna Nencini, Riccardo Zanaletti, Simon N. Haydar
  • MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF
    Publication number: 20100029606
    Abstract: The present invention provides compounds of formula (I) and compositions thereof, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.
    Type: Application
    Filed: January 16, 2008
    Publication date: February 4, 2010
    Applicants: WYETH, SIENA BIOTECH S.P.A.
    Inventors: Chiara Ghiron, Arianna Nencini, Iolanda Micco, Riccardo Zanaletti, Laura Maccari, Hendrick Bothmann, Simon N. Haydar, Maurizio Varrone, Carmela Pratelli, Boyd L. Harrison
  • MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF
    Publication number: 20100016288
    Abstract: Compounds with ?7 nicotinic acetylcholine receptor (?7 nAChR) agonistic activity, processes for their preparation, pharmaceutical compositions containing the same and the use thereof for the treatment of neurological and psychiatric diseases.
    Type: Application
    Filed: July 15, 2008
    Publication date: January 21, 2010
    Inventors: Hendrick BOTHMANN, Renza Roncarati, Jolanda Micco, Arianna Nencini, Chiara Ghiron
  • Novel methods for obtaining, identifying and applying nucleic acid sequences and (poly)peptides which increase the expression yields of periplasmic proteins in functional form
    Publication number: 20040152103
    Abstract: The present invention relates to a method for obtaining nucleic acid sequences encoding (poly)peptides which increase the expression yields of periplasmic proteins in functional form upon co-expression of said (poly)peptides and said periplasmic proteins. The invention also provides a method for the identification of said (poly)peptides. Furthermore, the present invention relates to a method for increasing the expression yields of periplasmic proteins in functional form by co-expressing (poly)peptides, for example Skp, FkpA, or a homolog of Skp or FkpA, in bacteria.
    Type: Application
    Filed: August 19, 2003
    Publication date: August 5, 2004
    Inventors: Andreas Plueckthun, Hendrick Bothmann
  • Methods for obtaining, identifying and applying nucleic acid sequences and (poly)peptides which increase the expression yields of periplasmic proteins in functional form
    Patent number: 6630317
    Abstract: The present invention relates to a method for obtaining nucleic acid sequences encoding (poly)peptides which increase the expression yields of periplasmic proteins in functional form upon co-expression of said (poly)peptides and said periplasmic proteins. The invention also provides a method for the identification of said (poly)peptides. Furthermore, the present invention relates to a method for increasing the expression yields of periplasmic proteins in functional form by co-expressing (poly)peptides, for example Skp, FkpA, or a homolog of Skp or FkpA, in bacteria.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: October 7, 2003
    Assignee: University of Zurich
    Inventors: Andreas Plückthun, Hendrick Bothmann