Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides a plant comprising a functional mammalian enzyme providing N-glycan biosynthesis that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.

Abstract: The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus 5 containing galactose residues on both arms and which are devoid of (or reduce in) xylose and fucose can be obtained. The invention is further directed to said glycoprotein obtained and host system comprising said protein.

Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.

Abstract: A residual current circuit breaker 1 has a partition wall 3 which separates an over-current protection device 4 from a residual current detection circuit 5. A plunger rod 24 extends through a bore 23 in the armature 21 of a coil 20 and is moved independently through the coil 20 to trip the breaker if a residual current is detected by the circuit 5. The plunger rod 24 is moved by a drive rod 31, the operation of which is controlled by a permanent magnet which retains the drive rod 31 retracted and an electromagnet which allows the drive rod 31 to drive forwardly under the action of a spring 32 in the event of a residual current being detected. The plunger rod 30 is reset by a reset lever 40 which is moved when an operating handle 18 of the breaker moves from a non-tripped to a tripped position on tripping of the breaker.

Abstract: An electric circuit breaker or load switch has at least one fixed contact, a movable contact and a spring system having a rigid arm and a leaf spring. The leaf spring is hinged to the arm to provide an arm-leaf spring assembly in the form of a toggle mechanism, having a first end hinged to a movably supported element bearing the movable contact, and a second end which is hingedly supported at a distance from and opposite the fixed contact. The second end, the first contact and the movable element are positioned such that the arm-leaf spring assembly in both the open and closed position of the contacts assumes a deflected position, by which the connection length of the switch is effectively reduced.

Abstract: An improved trip device for an electric switch comprises a yoke, a permanent magnet immovably positioned with respect to the yoke and a movably supported armature forming a first magnetic circuit, in which the armature is able to assume a first position under the influence of the magnetic field of the permanent magnet. A magnet winding and spring are provided for causing the armature to assume a second position in response to the magnetic field generated by an electric current, flowing during operation in the magnet winding. For adjusting the threshold value at which the armature is moved to its second position, a second magnetic circuit in the form of shunt interacting with the yoke and the permanent magnet is provided. The magnetically effective surface area of the shunt is smaller in the vicinity of the section thereof which interacts with the yoke than in the vicinity of the section which interacts with the permanent magnet.

Abstract: Current limiting switch for rapid circuit breaking, including at least one pair of contacts, one contact being mounted stationary and the other being mounted on a movable arm. The contact arm is rotatable about a fixed point upon surpassing a predetermined current threshold value, by means of an electromagnet energized by the current passing through the switch. The electromagnetic means comprise an electromagnet and a first and a second armature cooperating with the electromagnet, in which the first armature drives the movable contact in the direction of disengagement and the second armature releases a locking device, which blocks the movable contact in the direction of movement until the current threshold is reached.

Abstract: An actuation device which includes a holding magnet, an attracting magnet and an armature therebetween, both magnets being excitable by the same electromagnetic source. The armature comprises two half portions interconnected by a non-magnetic plate and operating such that upon saturation of the holding magnet with current, the armature will be disengaged by the holding magnet and drawn towards the attracting magnet.