Abstract: The invention relates to a molecular scaffold suitable for covalently binding at least one biologically active molecule to a carrier molecule, the scaffold comprising a polymeric structure and the biologically active molecules covalently bound to said polymeric structure, and wherein the scaffold further comprises a chemical group for covalently coupling of the scaffold to the carrier molecule. The biologically active molecule has a molecular weight of 3.000 Dalton or less, such as 1.700 Dalton-1.950 Dalton. The biologically active molecule is an amphiphilic molecule in some embodiments. The biologically active molecule is a single specific molecule or is a mixture of different types of molecules, when more than one biologically active molecules are covalently bound to the polymeric (or oligomeric) structure. In particular, the invention relates to monoclonal antibody-based antibody-drug conjugates with improved therapeutic window of the drug due to covalent linkage of (a cluster of) potentiator molecules, e.

Abstract: The invention relates to a therapeutic combination, comprising a first proteinaceous molecule comprising a first binding site for binding to a first epitope of a first cell-surface molecule, the first proteinaceous molecule provided with at least one saponin covalently bound to an amino-acid residue of said first proteinaceous molecule, and comprising a second pharmaceutical composition comprising a second proteinaceous molecule different from the first proteinaceous molecule, the second proteinaceous molecule comprising a second binding site for binding to a second epitope of a second cell-surface molecule different from the first cell-surface molecule, and comprising an effector moiety, wherein the second epitope is different from the first epitope. An aspect of the invention is a composition comprising the first proteinaceous molecule and the second proteinaceous molecule of the invention.

Abstract: A method is provided for maneuver planning and implementation for a vehicle by a vehicle-internal control unit. The control unit includes a strategic planning level for carrying out route planning, a tactical planning level for providing lane-accurate trajectories to possible destination points, and an operative planning level for selecting a destination point and a negotiable trajectory to the selected destination point. The planning levels have a cascading design. When each planning level is executed, an information exchange with neighboring vehicles is carried out via a communication link in order to ascertain collisions. When a collision is ascertained in at least one planning level, a maneuver coordination is carried out between the vehicles via the communication link. Moreover, a control unit is provided.

Abstract: The current invention relates to an effector moiety capable of inducing an intracellular effect when present inside a mammalian cell, the effector moiety comprising a payload conjugated with at least one saponin. The invention also relates to an antibody-drug conjugate comprising the effector moiety according to the invention, or a ligand-drug conjugate comprising the effector moiety of the invention, the effector moiety comprising covalently coupled saponin. The invention also relates to a therapeutic combination comprising: (a) the effector moiety of the invention, comprising at least one saponin, and optionally a pharmaceutically acceptable excipient; and (b) an antibody-drug conjugate or a ligand-drug conjugate, and optionally a pharmaceutically acceptable excipient.

Abstract: The present invention relates to a method of cooperatively coordinating future driving maneuvers of a vehicle with fellow maneuvers of at least one fellow vehicle, wherein trajectories for the vehicle are rated with an effort value each, trajectories and fellow trajectories of the fellow vehicle are combined into tuples, the trajectory and the associated effort value of a collision-free tuple are selected as reference trajectory and reference effort value, trajectories with a lower effort value than the reference effort value are classified as demand trajectories, trajectories with higher effort value than the reference effort value are classified as alternative trajectories, and a data packet having a trajectory set consisting of the reference trajectory and the associated reference effort value as well as at least one trajectory from a group comprising the demand trajectories and the alternative trajectories as well as the respective effort values is transmitted to the fellow vehicle.

Abstract: The present invention relates to a method of cooperatively coordinating future driving maneuvers of a vehicle with fellow maneuvers of at least one fellow vehicle, wherein a fellow data packet is received from the fellow vehicle, in which a fellow trajectory set of a fellow reference trajectory is contained, a trajectory from a trajectory set for the vehicle is selected as a reference trajectory for the vehicle using the fellow reference trajectory, wherein a trajectory which is collision-free towards the fellow reference trajectory is selected, the trajectories of the trajectory set are rated using limit trajectories, and at least one cooperation trajectory is selected from the trajectories of the trajectory set using the reference effort value, wherein a data packet containing the reference trajectory and the cooperation trajectory is transmitted to the fellow vehicle.

Abstract: A plausibility check module for a vehicle driver assistance system, including at least one sensor for detecting the vehicle surroundings, and Kl-module(s) to classify objects in the surroundings based on the sensor data supplied by the sensor with an internal processing chain established by parameters, the plausibility check module receiving pieces of reference information about objects in the surroundings supplied by other vehicles and/or by an infrastructure, and comparing the pieces of reference information with the classification result by the Kl-module and to initiate at least one measure for a deviation established by the comparison, so that the parameters of the processing chain of the Kl-module are adapted to the effect that the deviation is reduced in comparable situations. Also described are a driver assistance system having the plausibility check module and Kl-module(s), a method for calibrating a sensor for detecting the vehicle surroundings, and an associated computer program.

Abstract: A method is provided for correcting a positional probability distribution, at least two mobile systems each ascertaining a positional probability distribution through respective GNSS receivers, at least one mobile system ascertaining a distance to at least one second mobile system, the at least two mobile systems exchanging the ascertained positional probability distribution among themselves through a communication link, and by using the at least two ascertained positional probability distributions and the distance between the at least two mobile systems, an improvement of the positional probability distributions being calculated. Furthermore, a method for providing at least one correction term is provided.

Abstract: A method is provided for maneuver planning and implementation for a vehicle by a vehicle-internal control unit. The control unit includes a strategic planning level for carrying out route planning, a tactical planning level for providing lane-accurate trajectories to possible destination points, and an operative planning level for selecting a destination point and a negotiable trajectory to the selected destination point. The planning levels have a cascading design. When each planning level is executed, an information exchange with neighboring vehicles is carried out via a communication link in order to ascertain collisions. When a collision is ascertained in at least one planning level, a maneuver coordination is carried out between the vehicles via the communication link. Moreover, a control unit is provided.

Abstract: A plausibility check module for a vehicle driver assistance system, including at least one sensor for detecting the vehicle surroundings, and Kl-module(s) to classify objects in the surroundings based on the sensor data supplied by the sensor with an internal processing chain established by parameters, the plausibility check module receiving pieces of reference information about objects in the surroundings supplied by other vehicles and/or by an infrastructure, and comparing the pieces of reference information with the classification result by the Kl-module and to initiate at least one measure for a deviation established by the comparison, so that the parameters of the processing chain of the Kl-module are adapted to the effect that the deviation is reduced in comparable situations. Also described are a driver assistance system having the plausibility check module and Kl-module(s), a method for calibrating a sensor for detecting the vehicle surroundings, and an associated computer program.

Abstract: The present invention relates to a composition comprising a pharmacologically active agent coupled to a target cell specific component, and a saponin, to uses of said composition and to a kit comprising said composition. The invention also relates to a method of enhancing the function and/or the target cell specificity of a pharmacologically active agent. It furthermore relates to uses of a saponin.

Abstract: A redundance reduction method used in coding multichannel signals is proposed, where signals available in digitized form are predicted. A prediction error is computed, which is subsequently quantized and loaded for transmission over a transmission path. In the method, prediction is performed linearly in a backward-adaptive fashion for at least two channels simultaneously, and the statistical relationships of the signals within a channel and between at least two channels is taken into account. A device for decoding redundance-reduced multichannel signals is proposed. It comprises a linear backward-adaptive predictor for at least two channels.

Abstract: In a method for reducing data in a multi-channel data transmission, existing cross-relations between the signal channels are determined with due consideration of the transit-time difference. Upon the data transmission, a signal channel, the predictor coefficients and transit-time differences obtained from the cross-relations ascertained, and the prediction error are transmitted. At the receiver, the signal of the second channel is reconstructed from the transmitted signal channel, the predictor coefficients, the transit-time difference, and the prediction error. In this way, the amount of data to be transmitted in the case of multi-channel video or audio signals is reduced.