Patents by Inventor Hendrik-Jan Houthoff
Hendrik-Jan Houthoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220143204Abstract: The invention relates to the field of binding molecules comprising at least one single variable antibody domain, targeted at receptors present on myofibroblasts and/or hepatic stellate cells (HSCs). The invention also relates to a binding molecule comprising at least two single variable antibody domains, each targeting a receptor on HSCs and/or on myofibroblasts. The invention further relates to nucleic acids encoding such binding molecules, a host cell for expression of such binding molecules and to methods for preparing such binding molecules. The invention further relates to pharmaceutical compositions that comprise such binding molecule and to uses of such binding molecules and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.Type: ApplicationFiled: March 6, 2020Publication date: May 12, 2022Applicant: LinXis B.V.Inventors: Hendrik Jan Houthoff, Paulus Martinus Petrus van Bergen en Henegouwen, Niels Jurriaan Sijbrandi, Joey Armand Muns, Jan Hendrik Schooten, Sebas Daniƫl Pronk
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Publication number: 20210113712Abstract: Methods for preparing a cell targeting conjugate, which conjugate comprises a cell binding moiety conjugated to a secondary functional moiety. The disclosure further relates to the cell targeting conjugates obtainable by the method, to a pharmaceutical composition comprising the conjugates and to the secondary functional moieties as such. The disclosure also relates to the use of the cell targeting conjugates in the treatment of cancer.Type: ApplicationFiled: December 19, 2018Publication date: April 22, 2021Inventors: Eugen Merkul, Niels Jurriaan Sijbrandi, Joey Armand Muns, Augustinus Antonius Maria Silvester Van Dongen, Paulus Johannes Gerardus Maria Steverink, Hendrik Jan Houthoff
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Publication number: 20200345862Abstract: The disclosure relates to secondary functional moieties comprising a transition metal-based linker and a primary functional moiety bound thereto. The disclosure also relates to cell targeting conjugates comprising a linker of the invention. The disclosure further relates to a medicament comprising the cell targeting conjugate and to the use of the cell targeting conjugates in the diagnosis and treatment of cancer.Type: ApplicationFiled: December 19, 2018Publication date: November 5, 2020Inventors: Eugen Merkul, Niels Jurriaan Sijbrandi, Joey Armand Muns, Augustinus Antonius Maria Silvester Van Dongen, Paulus Johannes Gerardus Maria Steverink, Hendrik Jan Houthoff
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Patent number: 10668162Abstract: A first aspect of the disclosure relates to a method for preparing cell-targeting conjugates by coupling at least one functional moiety, such as a therapeutic compound, diagnostic compound or chelating agent to a targeting moiety. A second aspect of this disclosure relates to the cell-targeting conjugates obtainable with this method. A third aspect of the disclosure described herein relates to pharmaceutical compositions comprising the cell-targeting conjugates.Type: GrantFiled: January 4, 2013Date of Patent: June 2, 2020Assignee: LinXis B.V.Inventors: Hendrik Jan Houthoff, Augustinus A. M. S. Van Dongen, Robbert Jan Kok, Dennis Christian Johannes Waalboer, Sytze Jan Buwalda, Niels Jurriaan Sijbrandi
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Patent number: 10668168Abstract: This disclosure describes a method for preparing stable cell targeting conjugates. A further aspect of this disclosure relates to the stable cell targeting conjugates obtainable by the method and to pharmaceutical compositions comprising these stable cell targeting conjugates. A last aspect of this disclosure relates to the use of these conjugates and pharmaceutical compositions as a medicament.Type: GrantFiled: March 9, 2016Date of Patent: June 2, 2020Assignee: LinXis B.V.Inventors: Augustinus A. M. S. Van Dongen, Niels Jurriaan Sijbrandi, Dennis Christian Johannes Waalboer, Hendrik Jan Houthoff
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Publication number: 20190298846Abstract: Cell targeting conjugates that comprise a targeting moiety and one or more functional moieties bound thereto via a linker, wherein the linker comprises a transition metal complex and wherein at least 90% of the conjugates have a ratio of functional moieties to targeting moieties (DAR) of or less. A pharmaceutical composition comprising the cell targeting conjugates and the use of the conjugates and composition as a medicament, in particular, in the treatment of cancer.Type: ApplicationFiled: June 6, 2017Publication date: October 3, 2019Applicant: LinXis B.V.Inventors: Augustinus Antonius Maria Silvester Van Dongen, Niels Jurriaan Sijbrandi, Dennis Christian Johannes Waalboer, Hendrik Jan Houthoff
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Publication number: 20180055947Abstract: This disclosure describes a method for preparing stable cell targeting conjugates. A further aspect of this disclosure relates to the stable cell targeting conjugates obtainable by the method and to pharmaceutical compositions comprising these stable cell targeting conjugates. A last aspect of this disclosure relates to the use of these conjugates and pharmaceutical compositions as a medicament.Type: ApplicationFiled: March 9, 2016Publication date: March 1, 2018Inventors: Augustinus A. M. S. Van Dongen, Niels Jurriaan Sijbrandi, Dennis Christian Johannes Waalboer, Hendrik Jan Houthoff
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Publication number: 20140377174Abstract: A first aspect of the disclosure relates to a method for preparing cell-targeting conjugates by coupling at least one functional moiety, such as a therapeutic compound, diagnostic compound or chelating agent to a targeting moiety. A second aspect of this disclosure relates to the cell-targeting conjugates obtainable with this method. A third aspect of the disclosure described herein relates to pharmaceutical compositions comprising the cell-targeting conjugates.Type: ApplicationFiled: January 4, 2013Publication date: December 25, 2014Inventors: Hendrik Jan Houthoff, Augustinus A.M.S. Van Dongen, Robbert Jan Kok, Dennis Christian Johannes Waalboer, Sytze Jan Buwalda, Niels Jurriaan Sijbrandi
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Publication number: 20090023910Abstract: The invention provides a method for stably cross-linking a first nucleic acid sequence selected for being stably cross-linked in the presence of a second nucleic acid sequence selected for not being stably cross-linked in a nucleic acid molecule. The method comprises providing a nucleic acid sequence that is complementary to the first nucleic acid sequence; hybridizing the first nucleic acid sequence to its complementary sequence; and stably cross-linking the first nucleic acid sequence to the complementary sequence.Type: ApplicationFiled: August 25, 2008Publication date: January 22, 2009Applicant: KREATECH BIOTECHNOLOGY B.V.Inventors: Herman Volkers, Robert Heetebrij, Hendrik-Jan Houthoff, R.P.M. van Gijlswijk, Hendrikus Johannes Tanke, Anton Klaas Raap
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Publication number: 20060204987Abstract: The invention provides a method for stably cross-linking a first nucleic acid sequence selected for being stably cross-linked in the presence of a second nucleic acid sequence selected for not being stably cross-linked in a nucleic acid molecule. The method comprises providing a nucleic acid sequence that is complementary to the first nucleic acid sequence; hybridizing the first nucleic acid sequence to its complementary sequence; and stably cross-linking the first nucleic acid sequence to the complementary sequence.Type: ApplicationFiled: February 15, 2006Publication date: September 14, 2006Inventors: Herman Volkers, Robert Heetebrij, Hendrik-Jan Houthoff, R.P.M. Gijlswijk, Hendrikus Tanke, Anton Raap
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Publication number: 20040161743Abstract: The invention relates to a method for distinguishing at least two target bio-organic molecules with dyes selected from a pool of at least two dyes, the method comprising: (a) providing a first set of at least two probes, wherein each probe recognizes a target bio-organic molecule in a first set of target bio-organic molecules, and wherein each probe is distinctly-labelled with primary labels that are distinct from one another due to the presence of dyes in distinct ratios; (b) providing a second set of probes distinctly-labelled with said primary labels described in step (a), wherein each probe in said second probe set recognizes a target bio-organic molecule in a second set of target bio-organic molecules; wherein each probe in said first or second probe set is further labelled with the same first binary label, wherein said first binary label is distinct from said primary labels; and (c) contacting said at least two target bio-organic molecules with said probe sets, wherein said target bio-organic moleculesType: ApplicationFiled: December 5, 2001Publication date: August 19, 2004Inventors: Herman Volkers, Robert Heetebrij, Hendrik-Jan Houthoff, R.P.M. van Gijlswijk, Hendrikus Johannes Tanke, Anton Klaas Raap
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Publication number: 20040132106Abstract: The invention relates to a method for identifying a Mycobacterium species comprising the steps of:Type: ApplicationFiled: December 17, 2003Publication date: July 8, 2004Applicant: Kreatech Biotechnology B.V.Inventors: Hendrik-Jan Houthoff, Saskia Kroon-Swart, Remco Van Der Meulen, Soenita Goerdayal, Arend Kolk, Lenka Pereira Arias-Bouda, Sjoukje Kuyper
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Patent number: 6733983Abstract: The invention relates to a method for identifying a Mycobacterium species comprising the steps of: a) contacting at least one immuno-cross reactive antigen component of a mycobacterial species with a sample of a body fluid of a human or animal individual; b) contacting at least one antibody, which is capable of reacting with a mycobacterial antigen, with said body fluid sample; c) detecting the presence of antigen-antibody complexes, and identifying the Mycobacterium species present in said body fluid sample.Type: GrantFiled: July 7, 2000Date of Patent: May 11, 2004Assignee: Kreatech Biotechnology, B.V.Inventors: Hendrik-Jan Houthoff, Saskia Kroon-Swart, Remco Van Der Meulen, Soenita Goerdayal, Arend Kolk, Lenka Perira Arias-Bouda, Sjoukje Kuyper
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Publication number: 20030153019Abstract: The invention relates to a method for identifying a Mycobacterium species responsible for a mycobacterial infection in human or animal, comprising selecting a suitable mycobacterial species and strain; preparing at least one mycobacterial antigen, respectively antigen preparation; binding the antigen, respectively the antigen preparation to a suitable carrier; causing the binding antigen to react with antibodies from serum of an individual infected with a Mycobacterium species; making visible antigen-antibody reactions for a suitable antibody (sub-)class; and identifying the responsible Mycobacterium species on the basis of the reactions which are made visible. The invention further provides a diagnostic kit which takes the form of a dip-stick on which is arranged a carrier strip with mycobacterial antigens binding thereto, and means for visualizing antigen-antibody reactions occurring on the carrier after contact with the serum for testing.Type: ApplicationFiled: June 18, 2002Publication date: August 14, 2003Inventors: Pranab K. Das, Remco Maria Van Es, Hendrik Jan Houthoff
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Patent number: 6416962Abstract: The invention relates to a method for identifying a Mycobacterium species responsible for a mycobacterial infection in human or animal, comprising selecting a suitable mycobacterial species and strain; preparing at least one mycobacterial antigen, respectively antigen preparation; binding the antigen, respectively the antigen preparation to a suitable carrier; causing the binding antigen to react with antibodies from serum of an individual infected with a Mycobacterium species; making visible antigen-antibody reactions for a suitable antibody (sub-)class; and identifying the responsible Mycobacterium species on the basis of the reactions which are made visible. The invention further provides a diagnostic kit which takes the form of a dip-stick on which is arranged a carrier strip with mycobacterial antigens binding thereto, and means for visualizing antigen-antibody reactions occurring on the carrier after contact with the serum for testing.Type: GrantFiled: October 5, 1998Date of Patent: July 9, 2002Assignee: Kreatech Biotechnology B.V.Inventors: Pranab Khumar Das, Remco Maria Van Es, Hendrik Jan Houthoff
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Patent number: 6406850Abstract: The Invention relates to a method for providing at least one selected sequence in a nucleic acid with interstrand cross-links. The method comprises hybridizing at least one selected single strand sequence with a complementary single strand nucleic acid or a functional analogue thereof. The selected sequence or complementary nucleic acid or both comprise a cross-linking agent. The invention also relates to a method, referred to as COBRA, for the labeling of a set of at least two bio-organic molecules with a set of at least two colors, comprising generating said set of colors through combining ratio labeling with binary labeling.Type: GrantFiled: December 3, 1999Date of Patent: June 18, 2002Assignee: Kreatech Biotechnology B.V.Inventors: Herman Volkers, Robert Heetebrij, Hendrik-Jan Houthoff, R. P. M. van Gijlswijk, Hendrikus Johannes Tanke, Anton Klaas Raap
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Publication number: 20020012915Abstract: The Invention relates to a method for providing at least one selected sequence in a nucleic acid with interstrand cross-links. The method comprises hybridizing at least one selected single strand sequence with a complementary single strand nucleic acid or a functional analogue thereof. The selected sequence or complementary nucleic acid or both comprise a cross-linking agent. The invention also relates to a method, referred to as COBRA, for the labeling of a set of at least two bio-organic molecules with a set of at least two colors, comprising generating said set of colors through combining ratio labeling with binary labeling.Type: ApplicationFiled: December 3, 1999Publication date: January 31, 2002Inventors: Herman Volkers, Robert Heetebrij, Hendrik-Jan Houthoff, R.P.M. Van Gijlswijk, Hendrikus Johannes Tanke, Anton Klaas Raap
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Patent number: 6248531Abstract: The present invention is concerned with a trans-platinum based compound for use in a method for labelling a bio-organic molecule, having formula (I), wherein A represents a reactive moiety for attachment to a label, D represents a reactive moiety for attachment to a bio-organic molecule, and X1 and X2 represent the same or different inert moieties.Type: GrantFiled: December 21, 1999Date of Patent: June 19, 2001Assignee: Kreatech Biotechnology B.V.Inventors: Hendrik-Jan Houthoff, Jan Reedijk, Herman H. Volkers, Robert Jochem Heetebrij
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Patent number: 5817473Abstract: A method for identifying a Mycobacterium species responsible for a mycobacterial infection in human or animal, comprising selecting a suitable mycobacterial species and strain; preparing at least one mycobacterial antigen, respectively antigen preparation; binding the antigen, respectively the antigen preparation to a suitable carrier, causing the binding antigen to react with antibodies from serum of an individual infected with a Mycobacterium species; making visible antigen-antibody reactions for a suitable antibody (sub-)class; and identifying the responsible Mycobacterium on the basis of the reactions which are made visible. The invention further provides a diagnostic kit which takes the form of a dip-stick on which is arranged a carrier strip with mycobacterial antigens binding thereto, and visualizing reagents antigen-antibody reactions occurring on the carrier after contact with the serum for testing.Type: GrantFiled: November 20, 1995Date of Patent: October 6, 1998Assignee: Kreatech Biotechnology B.V.Inventors: Pranab Khumar Das, Remco Maria Van Es, Hendrik Jan Houthoff