Patents by Inventor Hendrik Sibolt van Damme
Hendrik Sibolt van Damme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11519845Abstract: The present invention relates to a device (10) for use in fluid sample analysis. It is described to position (310) a top part (20) of the device (10) adjacent to a base part (30) of the device so as to define a fluidic receiving region in between, the top part being provided with a through opening fluidly connected to the fluidic receiving region, and the bottom part being provided with a radiation window adjacent to the fluidic receiving region. A fluidic sample is supplied (320) through the opening (24). The fluidic sample is moved laterally (330) in the fluid receiving region without the use of an intermediary membrane between the top part and the base part. A radiation is emitted (340) to the fluid receiving region. A radiation is detected (350) that is reflected by the device. A presence of the fluidic sample is determined (360) on the basis of a measured reflectance value based on the detected radiation.Type: GrantFiled: May 16, 2017Date of Patent: December 6, 2022Assignee: Siemens Healthineers Nederland B.V.Inventors: Alexander Van Reenen, Markus Hendrikus Van Roosmalen, Hendrik Sibolt Van Damme
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Patent number: 11427815Abstract: A simplified method of obtaining purified nucleic acids uses a single buffer solution to both wash and elute nucleic acids bound to a binding phase. Use of a single buffer solution avoids the time-consuming aspect of using different wash and elution buffer solutions during multiple nucleic acid purification steps. The method for purifying nucleic acids using a single buffer solution includes steps of: exposing a sample comprising nucleic acids to a nucleic acid binding phase, where the nucleic acid binding phase may include magnetic particles, silica particles, or a mixture thereof; and allowing the nucleic acids to bind to the nucleic acid binding phase; washing the nucleic acids bound to the nucleic acid binding phase at least once with the single buffer solution at room temperature; and eluting the nucleic acids from the nucleic acid binding phase with ?50 ?l of the single buffer solution, at a temperature of ?40° Celsius.Type: GrantFiled: December 27, 2016Date of Patent: August 30, 2022Assignee: Koninklijke Philips N.V.Inventors: Hendrik Sibolt Van Damme, Wilbert Hendrik Bouwman
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Publication number: 20200309675Abstract: The present invention relates to a device (10) for use in fluid sample analysis. It is described to position (310) a top part (20) of the device (10) adjacent to a base part (30) of the device so as to define a fluidic receiving region in between, the top part being provided with a through opening fluidly connected to the fluidic receiving region, and the bottom part being provided with a radiation window adjacent to the fluidic receiving region. A fluidic sample is supplied (320) through the opening (24). The fluidic sample is moved laterally (330) in the fluid receiving region without the use of an intermediary membrane between the top part and the base part. A radiation is emitted (340) to the fluid receiving region. A radiation is detected (350) that is reflected by the device. A presence of the fluidic sample is determined (360) on the basis of a measured reflectance value based on the detected radiation.Type: ApplicationFiled: May 16, 2017Publication date: October 1, 2020Inventors: Alexander VAN REENEN, Markus Hendrikus VAN ROOSMALEN, Hendrik Sibolt VAN DAMME
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Publication number: 20190300873Abstract: The present invention relates to the purification of nucleic acids by an efficient and cost-effective method. In particular, the present invention addresses the laborious and time-consuming aspect of using different wash and elution buffer solutions during multiple, purification steps by using a single wash and elution buffer for nucleic acid purification. The use of a single wash and elution buffer solution, particularly in miniaturized environments, 10 represents a simplified way of obtaining purified nucleic acids in high amounts.Type: ApplicationFiled: December 27, 2016Publication date: October 3, 2019Inventors: Hendrik Sibolt VAN DAMME, Wilbert Hendrik BOUWMAN
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Patent number: 8586349Abstract: The present invention concerns a method for the detection of an analyte in a droplet of fluid comprising the steps of providing a solid phase with a hydrophobic surface comprising at least one capture zone on which at least one binding agent with affinity for the analyte is immobilized, applying said droplet to the surface of said solid phase, applying a force that makes the droplet travel along the surface of said solid phase along a predetermined path thereby allowing the droplet to repeatedly contact said binding agent on the capture zone, applying conditions wherein said analyte is allowed to bind to said binding agent and detecting a complex of analyte and binding reagent at the position of the capture zone. The effect of a moving droplet is that the reactants in the droplet are well mixed which eliminates the risk of diffusion limitation. Such advantageous mixing is not obtained with conventional assays in which the surface is continuously exposed to the liquid.Type: GrantFiled: August 6, 2001Date of Patent: November 19, 2013Assignee: Biomerieux B.V.Inventors: Thomas Augustinus Maria Beumer, Petrus Franciscus Hendrikus M. Verheijden, Hendrik Sibolt van Damme
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Patent number: 8339608Abstract: A method of detecting redispersion of particles into a solution using for example FTIR. The method including providing a sensor surface with dry particles; illuminating the sensor surface with light along a first optical path and detecting the light reflected by the sensor surface; providing a liquid to a volume in contact with the sensor surface; and detecting the reflected light while the dry particles redisperse into the liquid. The angle between the first optical path and the sensor surface fulfils the condition of total internal reflection. Further, an FTIR cartridge may be provided for use in said method. The cartridge including a sensor surface accessible for FTIR detection including at least one binding area wherein label particles are situated.Type: GrantFiled: October 30, 2008Date of Patent: December 25, 2012Assignee: Koninklijke Philips Electronics N.V.Inventors: Harold Johannes Antonius Brans, Albert Hendrik Jan Immink, Hendrik Sibolt Van Damme, Mara Johanna Jacoba Sijbers
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Patent number: 7419778Abstract: The present invention relates to methods for screening of cellular responses of cellular components comprising: (a) providing cellular components on the surface of a substrate, said substrate having immobilized thereon an array of detector molecules; (b) delivering test compounds to positions on the substrate corresponding to the arrayed detector molecules on the surface of said solid substrate; (c) incubating said test compounds with said cellular components on the surface of the solid support, under conditions allowing the induction of cellular responses; (d) assaying said cellular responses; and, identifying and characterizing the cellular responses induced by said test compounds. The present invention further relates to the uses of said methods as well as microarrays and kits for carrying out said methods.Type: GrantFiled: June 3, 2003Date of Patent: September 2, 2008Assignee: PameGene B.V.Inventors: Hendrik Sibolt Van Damme, Herman Jacobus Blok, Maria Helena Hilhorst, Colin John Ingham
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Patent number: 7105134Abstract: A device for holding a substrate comprises upper and lower plates adapted to receive the substrate sandwiched in the interface between the plates. Each plate has at least one opening with a projecting rim surrounding the opening and directed away from the interface. The openings in the upper and lower plates are preferably at least partially aligned in the sandwiched position of the plates. Each opening in the lower plate can be provided with a shielding member partially shielding the opening of the lower plate.Type: GrantFiled: March 11, 2002Date of Patent: September 12, 2006Assignee: PamGene B.V.Inventors: Hendrik Sibolt van Damme, Wilhelmus Marinus Carpay
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Patent number: 6864102Abstract: The present invention relates to a device for performing an assay, which device comprises a substrate having oriented through-going channels, said channels opening out on a surface for sample application, the channels in at least one area of the surface for sample application being provided with a first binding substance capable of binding to an analyte. The object of the present invention is to provide a substrate having both a high channel density and a high porosity, allowing high density arrays comprising different first binding substances to be applied to the surface for sample application. More in particular, the object of the present invention is to provide a device comprising a relatively cheap substrate that does not require the use of any typical microfabrication technology and, that offers an improved control over the liquid distribution over the surface of the substrate.Type: GrantFiled: May 1, 2001Date of Patent: March 8, 2005Assignee: PamGene International B.V.Inventors: Hendrik Sibolt van Damme, Hermanus Johannes Maria Kreuwel
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Patent number: 6855539Abstract: Disclosed is a device useful for performing an assay comprising a substrate having interconnecting channels that open out onto a surface for sample application, the channels being provided in at least one cross-sectional area with a first binding substance capable of binding a particular analyte, the substrate being an electrochemically manufactured metal oxide membrane and containing the first binding substance within the through-going channels. Similar devices are also useful for chemical synthesis. Assay and chemical synthesis methods are also disclosed, as are kits for performing the assays or chemical syntheses.Type: GrantFiled: November 27, 2001Date of Patent: February 15, 2005Assignee: PamGene International B.V.Inventors: Hendrik Sibolt van Damme, Hermanus Johannes Maria Kreuwel, Tim Kievits, Marinus Gerardus Johannus van Beuningen, Pieter Jacob Boender
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Publication number: 20040043421Abstract: The present invention concerns a method for the detection of an analyte in a droplet of fluid comprising the steps of providing a solid phase with a hydrophobic surface comprising at least one capture zone on which at least one binding agent with affinity for the analyte is immobilised, applying said droplet to the surface of said solid phase, applying a force that makes the droplet travel along the surface of said solid phase along a predetermined path thereby allowing the droplet to repeatedly contact said binding agent on the capture zone, applying conditions wherein said analyte is allowed to bind to said binding agent and detecting a complex of analyte and binding reagent at the position of the capture zone. The effect of a moving droplet is that the reactants in the droplet are well mixed which eliminates the risk of diffusion limitation. Such advantageous mixing is not obtained with conventional assays in which the surface is continuously exposed to the liquid.Type: ApplicationFiled: August 1, 2003Publication date: March 4, 2004Inventors: Thomas Augustinus Maria Beumer, Petrus Franciscus Hendrikus M. Verheijden, Hendrik Sibolt van Damme
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Patent number: 6635493Abstract: The present invention relates to a device for performing an assay, which device comprises a substrate having oriented through-going channels, said channels opening out on a surface for sample application, the channels in at least one area of the surface for sample application being provided with a first binding substance capable of binding to an analyte. The object of the present invention is to provide a substrate having both a high channel density and a high porosity, allowing high density arrays comprising different first binding substances to be applied to the surface for sample application. More in particular, the object of the present invention is to provide a device comprising a relatively cheap substrate that does not require the use of any typical microfabrication technology and, that offers an improved control over the liquid distribution over the surface of the substrate.Type: GrantFiled: April 30, 2001Date of Patent: October 21, 2003Assignee: PamGene B.V.Inventors: Hendrik Sibolt van Damme, Hermanus Johannes Maria Kreuwel
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Publication number: 20030059348Abstract: A device for holding a substrate comprises upper and lower plates adapted to receive the substrate sandwiched in the interface between the plates. Each plate has at least one opening with a projecting rim surrounding the opening and directed away from the interface. The openings in the upper and lower plates are preferably at least partially aligned in the sandwiched position of the plates. Each opening in the lower plate can be provided with a shielding member partially shielding the opening of the lower plate.Type: ApplicationFiled: March 11, 2002Publication date: March 27, 2003Inventors: Hendrik Sibolt van Damme, Wilhelmus Marinus Carpay
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Publication number: 20020164584Abstract: Disclosed is a device useful for performing an assay comprising a substrate having interconnecting channels that open out onto a surface for sample application, the channels being provided in at least one cross-sectional area with a first binding substance capable of binding a particular analyte, the substrate being an electrochemically manufactured metal oxide membrane and containing the first binding substance within the through-going channels. Similar devices are also useful for chemical synthesis. Assay and chemical synthesis methods are also disclosed, as are kits for performing the assays or chemical syntheses.Type: ApplicationFiled: November 27, 2001Publication date: November 7, 2002Inventors: Tim Kievits, Marinus Gerardus Johannus Van Beuningen, Pieter Jacob Boender, Hendrik Sibolt van Damme, Hermanus Johannes Maria Kreuwel
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Publication number: 20020127738Abstract: The present invention relates to a device for performing an assay, which device comprises a substrate having oriented through-going channels, said channels opening out on a surface for sample application, the channels in at least one area of the surface for sample application being provided with a first binding substance capable of binding to an analyte. The object of the present invention is to provide a substrate having both a high channel density and a high porosity, allowing high density arrays comprising different first binding substances to be applied to the surface for sample application. More in particular, the object of the present invention is to provide a device comprising a relatively cheap substrate that does not require the use of any typical microfabrication technology and, that offers an improved control over the liquid distribution over the surface of the substrate.Type: ApplicationFiled: May 1, 2001Publication date: September 12, 2002Inventors: Hendrik Sibolt van Damme, Hermanus Johannes Maria Kreuwel
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Publication number: 20020102565Abstract: The present invention relates to a device for performing an assay, which device comprises a substrate having oriented through-going channels, said channels opening out on a surface for sample application, the channels in at least one area of the surface for sample application being provided with a first binding substance capable of binding to an analyte. The object of the present invention is to provide a substrate having both a high channel density and a high porosity, allowing high density arrays comprising different first binding substances to be applied to the surface for sample application. More in particular, the object of the present invention is to provide a device comprising a relatively cheap substrate that does not require the use of any typical microfabrication technology and, that offers an improved control over the liquid distribution over the surface of the substrate.Type: ApplicationFiled: April 30, 2001Publication date: August 1, 2002Applicant: PamGene B.V.Inventors: Hendrik Sibolt van Damme, Hermanus Johannes Maria Kreuwel
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Patent number: 6225131Abstract: A device for performing an assay comprising a substrate having through-going channels that open out onto a surface for sample application, the channels being provided in at least one cross-sectional area with a first binding substance capable of binding a particular analyte, the substrate being an electrochemically manufactured metal oxide membrane and containing the first binding substance within the through-going channels.Type: GrantFiled: October 25, 1999Date of Patent: May 1, 2001Assignee: Akzo Nobel N.V.Inventors: Hendrik Sibolt van Damme, Hermanus Johannes Maria Kreuwel