Abstract: This invention relates to a process for the preparation of 7-(4-methyl-1-piperazinyl)benzoxazol-2(3H)-one hydrochloride, a partial dopamine-D2 receptor agonist and a full serotonin 5-HT1A receptor agonist. This invention also relates to the monohydrate of said compound, as well as to pharmaceutical compositions containing these compounds, to methods for preparing these compounds, to methods for preparing intermediates useful for their synthesis, and to methods for preparing compositions containing these compounds.

Abstract: This invention relates to a process for the preparation of 7-(4-methyl-1-piperazinyl)benzoxazol-2(3H)-one hydrochloride, a partial dopamine-D2 receptor agonist and a full serotonin 5-HT1A receptor agonist. 7-(4-methyl-1-piperazinyl)benzoxazol-2(3H)-one hydrochloride The invention also relates to polymorphic forms of said compound, as well as to pharmaceutical compositions containing these compounds, to methods for preparing the compounds, to methods for preparing intermediates useful for their synthesis, and to methods for preparing compositions containing these compounds.

Abstract: The invention is related to an iontophoretic method for the delivery of a compound of the formula wherein R is defined herein, and pharmaceutically acceptable salts and prodrugs thereof; and, wherein the method comprises: (a) applying a transdermal device to the skin of a living body, wherein the transdermal device has a reservoir containing the compound of formula I or a composition thereof and optionally a pharmaceutically acceptable electrolyte; (b) causing current to flow through the skin so as to iontophoretically deliver the compound of formula I. The invention is further related to iontophoretic systems and to kits containing the iontophoretic system combined with one or more cartridges containing a compound of formula I, and to cartridges containing a compound of formula I.

Abstract: The present invention is directed to compositions, kits, and methods for a titration schedule to facilitate the treatment of a central nervous system condition or disorder by administering a plurality of dosage units of a composition comprising a compound 7-(4-methyl)-1-piperazinyl-2(3H)-benzoxazolone (INN pardoprunox).

Abstract: The invention relates to a wound dresssing comprising (1) a lower layer of a hydrogel of a polymer cross-linked under the influence of electron beam (E.B.) radiation, to which optionally one or more medicinal and/or antibacterial agents and/or one or more auxiliary substances have been added, and (2) a polymeric top layer, in which the top layer consists at least substantially of an elastomer selected from the group consisting of a silicone rubber, a polyetherpolyurethane copolymer, a polyester-polyurethane copolymer, a polyether-polyester copolymer and an optionally modified block copolymer based on suitable vinyl monomers, and that a fibrous layer is provided between the lower layer and the top layer for bonding the two layers together.The invention further relates to a method of preparing said wound dressing.