Abstract: Solid porous supports find use in array analysis, as they offer high surface area for contacting the analyzed sample. The present invention provides a solid porous support suitable for array analysis having first and second surfaces, and comprising channels extending from said first surface to said second surface, characterised in that at least one conductive material is applied to predefined regions on said first surface and/or on said second surface and/or inside the channels contained within said solid porous support. Such conductive material(s) may form a high-precision grid delineating physically distinct compartments within the support and thus reduce the risk of cross-contamination in array analysis. Additionally, such conductive material(s) may directly participate in reactions performed on the array by means of their electrical and/or thermal conductivity.

Abstract: The present invention relates methods for screening of cellular responses comprising: (a) providing a solid porous support having first and second surfaces and at least one area with a plurality of through-going channels (b) providing cellular components on said first and/or second surface of said solid porous support, wherein said solid porous support retains said cellular compounds on its surface; (c) providing a supply chamber at said first and/or second surface and opposite to said cellular components (d) subjecting all or part of said cellular components to one or more effectors; wherein at least one effector is delivered from said supply chamber through the porous support; (e) incubating the said all or part of cellular components with said effectors under conditions allowing the induction of cellular responses in the said all or part of cellular components; (f) optionally providing detector molecules to the said all or part of cellular components for assaying cellular responses (g) assaying for cellula

Abstract: The present invention relates to methods for screening of cellular responses of cellular components comprising: (a) providing cellular components on the surface of a substrate, said substrate having immobilized thereon an array of detector molecules; (b) delivering test compounds to positions on the substrate corresponding to the arrayed detector molecules on the surface of said solid substrate; (c) incubating said test compounds with said cellular components on the surface of the solid support, under conditions allowing the induction of cellular responses; (d) assaying said cellular responses; and, identifying and characterizing the cellular responses induced by said test compounds. The present invention further relates to the uses of said methods as well as microarrays and kits for carrying out said methods.