Patents by Inventor Heng-Keang Lim

Heng-Keang Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Patent number: 11214566
    Abstract: The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: January 4, 2022
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jie Chen, Matthew Donahue, Heng-Keang Lim, Ronghui Lin, Rhys Salter, Jiejun Wu, Yong Gong
  • Substituted Pyridine Derivatives Useful As C-FMS Kinase Inhibitors
    Publication number: 20200399254
    Abstract: The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
    Type: Application
    Filed: September 2, 2020
    Publication date: December 24, 2020
    Inventors: Jie Chen, Matthew Donahue, Heng-Keang Lim, Ronghui Lin, Rhys Salter, Jiejun Wu, Yong Gong
  • Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Patent number: 10800764
    Abstract: The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: October 13, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jie Chen, Matthew Donahue, Heng-Keang Lim, Ronghui Lin, Rhys Salter, Jiejun Wu, Yong Gong
  • Substituted Pyridine Derivatives Useful As C-FMS Kinase Inhibitors
    Publication number: 20180346454
    Abstract: The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
    Type: Application
    Filed: August 13, 2018
    Publication date: December 6, 2018
    Inventors: Jie CHEN, Matthew DONAHUE, Heng-Keang LIM, Ronghui LIN, Rhys SALTER, Jiejun WU, Yong GONG
  • Substituted pyridine derivatives useful as c-fms kinase inhibitors
    Patent number: 10071991
    Abstract: The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: September 11, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jie Chen, Matthew Donahue, Heng-Keang Lim, Ronghui Lin, Rhys Salter, Jiejun Wu, Yong Gong
  • SUBSTITUTED PYRIDINE DERIVATIVES USEFUL AS C-FMS KINASE INHIBITORS
    Publication number: 20170158678
    Abstract: The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
    Type: Application
    Filed: February 23, 2017
    Publication date: June 8, 2017
    Inventors: Jie CHEN, Matthew DONAHUE, Heng-Keang LIM, Ronghui LIN, Rhys SALTER, Jiejun WU, Yong GONG
  • Substituted pyridine derivatives useful as C-FMS kinase inhibitors
    Patent number: 9611259
    Abstract: The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: April 4, 2017
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jie Chen, Matthew Donahue, Heng-Keang Lim, Ronghui Lin, Rhys Salter, Jiejun Wu, Yong Gong
  • Method for Determining the Stability of Organic Methyleneamines in the Presence of Semicarbazide-Sensitive Amine Oxidase
    Publication number: 20140363836
    Abstract: The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing an methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.
    Type: Application
    Filed: May 12, 2014
    Publication date: December 11, 2014
    Inventors: Adedayo ADEDOYIN, Michael ANGELASTRO, Julie BICK, Jennifer CAIRNS, Yongqing HUANG, Guyan LIANG, Heng-Keang LIM
  • Method for determining the stability of organic methyleneamines in the presence of semicarbazide-sensitive amine oxidase
    Patent number: 8883410
    Abstract: The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing a methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.
    Type: Grant
    Filed: November 18, 2012
    Date of Patent: November 11, 2014
    Assignee: Sanofi
    Inventors: Adedayo Adedoyin, Michael R. Angelastro, Julie Bick, Jennifer Caims, Yongqing Huang, Guyan Liang, Heng-Keang Lim
  • Compounds having inhibitory activity against sodium-dependent glucose transporter
    Patent number: 7666845
    Abstract: The invention is directed to compounds of the formula (I) described herein, a pharmaceutically acceptable salt thereof, or a prodrug thereof, and pharmaceutical compositions and methods of treatment.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: February 23, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Kevin L. Cook, Heng-Keang Lim, Frank J. Villani, Lorraine Scott, Christian Andrew Baumann
  • METHOD FOR DETERMINING THE STABILITY OF ORGANIC METHYLENEAMINES IN THE PRESENCE OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE
    Publication number: 20100028895
    Abstract: The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing an methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.
    Type: Application
    Filed: January 8, 2008
    Publication date: February 4, 2010
    Inventors: Adedayo Adedoyin, Michael Angelastro, Julie Bick, Jennifer Cairns, Yongqing Huang, Guyan Liang, Heng-Keang Lim
  • COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDENT GLUCOSE TRANSPORTER
    Publication number: 20090029927
    Abstract: The invention is directed to compounds of the formula (I) described herein, a pharmaceutically acceptable salt thereof, or a prodrug thereof, and pharmaceutical compositions and methods of treatment.
    Type: Application
    Filed: December 3, 2007
    Publication date: January 29, 2009
    Inventors: Kevin L. Cook, Heng-Keang Lim, Frank J. Villani, Lorraine Scott, Christian Andrew Baumann