Patents by Inventor Heng Zhong
Heng Zhong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240327852Abstract: The disclosure relates to methods of transformation and related compositions. In some aspects, the methods comprise wounding at least part of a region of an embryo axis comprising an epicotyl, a shoot apical meristem, and cotyledonary node, or the corresponding region in a monocot embryo axis, to produce a wounded explant, and contacting the wounded explant with a heterologous polynucleotide. In some aspects, the methods further comprise on or more selection steps which may be done in planta.Type: ApplicationFiled: November 24, 2020Publication date: October 3, 2024Applicant: SYNGENTA CROP PROTECTION AGInventors: Heng Zhong, Changbao Li
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Patent number: 12013870Abstract: Technology for routing queries in a system with a plurality of nodes (for example online analytical processing sub-systems) where each node has an associated replicated local database and a local latency value and replication velocity values. The workload balancing for incoming received queries among and between the plurality of nodes is based, at least in part, on consideration of latency values and/or replication velocity values for the various nodes. The best node to handle a given query is thereby selected and the query is routed to the selected node for response.Type: GrantFiled: July 29, 2022Date of Patent: June 18, 2024Assignee: International Business Machines CorporationInventors: Manogari Nogi Simanjuntak, Sowmya Kameswaran, Daniel Martin, Jia Heng Zhong
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Patent number: 11898149Abstract: The present invention relates to methods and compositions for modifying a target site in the genome of a plant cell. Such modifications include integration of a transgene and mutations. The present invention also relates to methods and compositions for identifying and enriching for cells which comprise a modified target site.Type: GrantFiled: March 10, 2023Date of Patent: February 13, 2024Assignee: Syngenta Participations AGInventors: Zhongying Chen, Myoung Kim, Mary-Dell Chilton, Heng Zhong, Weining Gu, Yaping Jiang, Qiudeng Que
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Publication number: 20240037115Abstract: Technology for routing queries in a system with a plurality of nodes (for example online analytical processing sub-systems) where each node has an associated replicated local database and a local latency value and replication velocity values. The workload balancing for incoming received queries among and between the plurality of nodes is based, at least in part, on consideration of latency values and/or replication velocity values for the various nodes. The best node to handle a given query is thereby selected and the query is routed to the selected node for response.Type: ApplicationFiled: July 29, 2022Publication date: February 1, 2024Inventors: Manogari Nogi Simanjuntak, Sowmya KAMESWARAN, Daniel Martin, JIA HENG ZHONG
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Publication number: 20230265446Abstract: The present invention relates to methods and compositions for modifying a target site in the genome of a plant cell. Such modifications include integration of a transgene and mutations. The present invention also relates to methods and compositions for identifying and enriching for cells which comprise a modified target site.Type: ApplicationFiled: March 10, 2023Publication date: August 24, 2023Applicant: SYNGENTA PARTICIPATIONS AGInventors: Zhongying Chen, Myoung Kim, Mary-Dell Chilton, Heng Zhong, Weining Gu, Yaping Jiang, Qiudeng Que
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Patent number: 11643664Abstract: The present invention relates to methods and compositions for modifying a target site in the genome of a plant cell. Such modifications include integration of a transgene and mutations. The present invention also relates to methods and compositions for identifying and enriching for cells which comprise a modified target site.Type: GrantFiled: February 17, 2021Date of Patent: May 9, 2023Assignee: Syngenta Participations AGInventors: Zhongying Chen, Myoung Kim, Mary-Dell Chilton, Heng Zhong, Weining Gu, Yaping Jiang, Qiudeng Que
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Publication number: 20230130592Abstract: The invention provides three novel disarmed strains of Agrobacteriumtumefaciens bacteria useful for the transformation of plants. The invention provides three engineered A. tumefaciens Chry5 strains or bacterial cells thereof which comprise the Chry5 strain chromosomal background and a disarmed pTiChry5 vector, and methods of using said bacterial strains or cells for transformation of fungal or plant cells, in particular dicot or monocot plant cells, including soybean, maize, wheat, and sugarcane cells. The invention further relates to the transgenic plants created by these methods.Type: ApplicationFiled: October 18, 2022Publication date: April 27, 2023Applicant: SYNGENTA PARTICIPATIONS AGInventors: Zhongying Chen, Qiudeng Que, Mark Scott Rose, Heng Zhong, Mary-Dell Chilton, Eric Levy, Yingping Lucy Qin
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Publication number: 20230114951Abstract: The present invention relates to methods and compositions for targeted insertion of polynucleotide molecules into ideal target sites in the genome of a maize plant. The present invention relates to maize recombinant molecules comprising heterologous sequences and also to methods of integrating a DNA of interest into a target maize genomic locus in a maize genome. The present invention also relates to regenerated maize plants or plant parts comprising the recombinant molecules and/or a DNA of interest.Type: ApplicationFiled: August 26, 2022Publication date: April 13, 2023Applicant: SYNGENTA PARTICIPATIONS AGInventors: Yinping Lucy Qin, Mark Rose, Zhongying Chen, Heng Zhong, Weining Gu, Wenling Wang, Qiudeng Que, Ailing Zhou, Mary-Dell Chilton
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Publication number: 20230086203Abstract: A method, computer program product, and system include a processor(s) obtaining a query request from an application via a source database management system to a target database management system, where the query request comprises a query and a query timestamp indicating a last update to table(s) in the source database management system referenced in the query request. The processor(s) determines a table update timestamp indicating a last time when the table(s) in the source database management system referenced in the query request was replicated to the target database management system. The processor(s) generates an indicator where the indicator represent a difference between the query timestamp and the table update timestamp. The processor(s) executes the query in the target database management system. The processor(s) transmit a query result and the indicator to the source database management system.Type: ApplicationFiled: September 15, 2021Publication date: March 23, 2023Inventors: Daniel Martin, Jia Heng Zhong, Sowmya Kameswaran, Manogari Nogi Simanjuntak
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Publication number: 20220389437Abstract: Conventional gene transformation requires tissue culture, and some elite lines have very low transformation efficiency in tissue culture. The disclosure relates to methods of in planta transformation. In some aspects, an axillary meristem of a plant is wounded and contacted with a transformation agent. The wounded axillary meristem is then regenerated and treated with a selection step, resulting in transformed tissue that can produce transgenic seeds.Type: ApplicationFiled: November 24, 2020Publication date: December 8, 2022Applicant: SYNGENTA CROP PROTECTION AGInventors: Changbao Li, Wenjin Yu, Heng Zhong, Hua-ping Zhou
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Patent number: 11505801Abstract: The invention provides three novel disarmed strains of Agrobacterium tumefaciens bacteria useful for the transformation of plants. The invention provides three engineered A. tumefaciens Chry5 strains or bacterial cells thereof which comprise the Chry5 strain chromosomal background and a disarmed pTiChry5 vector, and methods of using said bacterial strains or cells for transformation of fungal or plant cells, in particular dicot or monocot plant cells, including soybean, maize, wheat, and sugarcane cells. The invention further relates to the transgenic plants created by these methods.Type: GrantFiled: July 26, 2018Date of Patent: November 22, 2022Assignee: Syngenta Participations AGInventors: Zhongying Chen, Qiudeng Que, Mark Scott Rose, Heng Zhong, Mary-Dell Chilton, Eric Levy, Yingping Lucy Qin
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Patent number: 11459577Abstract: The present invention relates to methods and compositions for targeted insertion of polynucleotide molecules into ideal target sites in the genome of a maize plant. The present invention relates to maize recombinant molecules comprising heterologous sequences and also to methods of integrating a DNA of interest into a target maize genomic locus in a maize genome. The present invention also relates to regenerated maize plants or plant parts comprising the recombinant molecules and/or a DNA of interest.Type: GrantFiled: December 12, 2018Date of Patent: October 4, 2022Assignee: Syngenta Participations AGInventors: Yinping Lucy Qin, Mark Rose, Zhongying Chen, Heng Zhong, Weining Gu, Wenling Wang, Qiudeng Que, Ailing Zhou, Mary-Dell Chilton
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Patent number: 11163792Abstract: A computer-implemented method, system, and non-transitory computer program product for work assignment for parallelized database synchronization. Data changes to a source database are identified from a change log for the source database. The data changes are batched into data change chunks of data changes. An estimated processing cost for processing of each of the data change chunks to apply the data changes in the data change chunks to a target database is determined. A priority queue in which the data change chunks are identified in order of estimated processing cost is generated. Each data change chunk identified in the priority queue is assigned to a processing thread in a plurality of processing threads for processing in order by estimated processing cost from higher estimated processing cost to lower estimated processing cost to apply the data changes in the data change chunks to the target database.Type: GrantFiled: May 29, 2019Date of Patent: November 2, 2021Assignee: International Business Machines CorporationInventors: Jia Heng Zhong, Daniel Martin, Sowmya Kameswaran, Manogari Nogi Simanjuntak
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Patent number: 11093477Abstract: A method, system, and program product for enabling multiple source database coherency is provided. The method includes detecting an incoming query to be executed with respect to an accelerator server. An initial timestamp of the incoming query is analyzed and additional timestamps of database tables referenced by the incoming query are retrieved. It is determined that each timestamp of the additional timestamps is reached with respect to a corresponding replication engine and target data from the database tables is synchronized with source data of a source database. In response, the incoming query is accelerated for execution with respect to a target database management system.Type: GrantFiled: March 17, 2020Date of Patent: August 17, 2021Assignee: International Business Machines CorporationInventors: Daniel Martin, Jia Heng Zhong, Sowmya Kameswaran, Manogari Nogi Simanjuntak
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Publication number: 20210214736Abstract: The present invention relates to methods and compositions for modifying a target site in the genome of a plant cell. Such modifications include integration of a transgene and mutations. The present invention also relates to methods and compositions for identifying and enriching for cells which comprise a modified target site.Type: ApplicationFiled: February 17, 2021Publication date: July 15, 2021Applicant: SYNGENTA PARTICIPATIONS AGInventors: Zhongying Chen, Myoung Kim, Mary-Dell Chilton, Heng Zhong, Weining Gu, Yaping Jiang, Qiudeng Que
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Publication number: 20210189409Abstract: The present invention relates to methods and compositions for targeted insertion of polynucleotide molecules into ideal target sites in the genome of a maize plant. The present invention relates to maize recombinant molecules comprising heterologous sequences and also to methods of integrating a DNA of interest into a target maize genomic locus in a maize genome. The present invention also relates to regenerated maize plants or plant parts comprising the recombinant molecules and/or a DNA of interest.Type: ApplicationFiled: December 12, 2018Publication date: June 24, 2021Applicant: SYNGENTA PARTICIPATIONS AGInventors: Yinping Lucy Qin, Mark Rose, Zhongying Chen, Heng Zhong, Weining Gu, Wenling Wang, Qiudeng Que, Ailing Zhou, Mary-Dell Chilton
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Publication number: 20210087557Abstract: The present invention relates to methods and compositions for chimeric RNA comprising a guide RNA and bait RNA for modifying a target site in the genome of a cell. Such modifications include integration of a transgene and allelic mutations and modifications of native genes. Also provided are plants comprising a modified nucleic acid sequence compared to the native gene integrated into a targeted genomic site in the plant genome.Type: ApplicationFiled: July 26, 2018Publication date: March 25, 2021Applicant: SYNGENTA PARTICIPATIONS AGInventors: Zhongying Chen, Mary-Dell Chilton, Shujie Dong, Qiudeng Que, Heng Zhong
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Publication number: 20200380011Abstract: A computer-implemented method, system, and non-transitory computer program product for work assignment for parallelized database synchronization. Data changes to a source database are identified from a change log for the source database. The data changes are batched into data change chunks of data changes. An estimated processing cost for processing of each of the data change chunks to apply the data changes in the data change chunks to a target database is determined. A priority queue in which the data change chunks are identified in order of estimated processing cost is generated. Each data change chunk identified in the priority queue is assigned to a processing thread in a plurality of processing threads for processing in order by estimated processing cost from higher estimated processing cost to lower estimated processing cost to apply the data changes in the data change chunks to the target database.Type: ApplicationFiled: May 29, 2019Publication date: December 3, 2020Inventors: Jia Heng Zhong, Daniel Martin, Sowmya Kameswaran, Manogari Nogi Simanjuntak
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Publication number: 20200208162Abstract: The invention provides three novel disarmed strains of Agrobacterium tumefaciens bacteria useful for the transformation of plants. The invention provides three engineered A. tumefaciens Chry5 strains or bacterial cells thereof which comprise the Chry5 strain chromosomal background and a disarmed pTiChry5 vector, and methods of using said bacterial strains or cells for transformation of fungal or plant cells, in particular dicot or monocot plant cells, including soybean, maize, wheat, and sugarcane cells. The invention further relates to the transgenic plants created by these methods.Type: ApplicationFiled: July 26, 2018Publication date: July 2, 2020Applicant: SYNGENTA PARTICIPATIONS AGInventors: Zhongying Chen, Qiudeng Que, Mark Scott Rose, Heng Zhong, Mary-Dell Chilton, Eric Levy, Yingping Lucy Qin
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Patent number: 10549344Abstract: A liquid composition includes copper particles, an organic acid, and a solvent. The copper particle has a particle size of 0.5 ?m˜30 ?m which falls in a micron scale. The liquid composition performs reaction sintering by redox reactions taken place between the copper particles and an organic acid solution at a low temperature of 150° C. in order to produce a dense copper layer and improve the conventional micron-scale copper particles that requires a protective atmosphere for the high-temperature sintering before achieving the required densification. This liquid composition also prevents an excessive oxidation of the nano copper particles during the low-temperature sintering process and a failure of the dense sintering. Due to the agglomeration of nano copper particles, some areas have to be sintered first, so that the sintered products have a good uniformity of tissue and a low resistance below 0.04 ohm per square (?/?).Type: GrantFiled: October 31, 2017Date of Patent: February 4, 2020Assignee: SHENMAO TECHNOLOGY INC.Inventors: Chang-Meng Wang, Hsiang-Chuan Chen, Ruei-Ying Sheng, Chen-Yi Chen, Albert T. Wu, Chih-Hao Chen, Yuan-Heng Zhong