Abstract: Pharmaceutical and chemical intermediates and relevant chemicals, and relates to a novel preparation method of N-substituted dibenzo[a,c]carbazole compound. O-alkynylaniline and derivatives thereof as raw materials conduct a cascade cyclization reaction in an anhydrous organic solvent in the presence of catalysts, oxidants and additives, and are converted into the N-substituted dibenzo[a,c]carbazole compound. The preparation method of the N-substituted dibenzo[a,c]carbazole compound has fewer reaction steps, low cost of raw material, mild reaction conditions and convenient operation. Moreover, the obtained product has high yield and high purity, fully meets the quality requirements for drug intermediates, and provides favorable conditions for the industrial production.

Abstract: Pharmaceutical and chemical intermediates and relevant chemicals, and relates to a novel preparation method of N-substituted dibenzo[a,c]carbazole compound. O-alkynylaniline and derivatives thereof as raw materials conduct a cascade cyclization reaction in an anhydrous organic solvent in the presence of catalysts, oxidants and additives, and are converted into the N-substituted dibenzo[a,c]carbazole compound. The preparation method of the N-substituted dibenzo[a,c]carbazole compound has fewer reaction steps, low cost of raw material, mild reaction conditions and convenient operation. Moreover, the obtained product has high yield and high purity, fully meets the quality requirements for drug intermediates, and provides favorable conditions for the industrial production.