Patents by Inventor Henner Straub

Henner Straub has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hereroaryl derivatives of monocyclic beta-lactam antibiotics
    Patent number: 5705645
    Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: January 6, 1998
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William H. Koster, Joseph E. Sundeen, Henner Straub, Peter Ermann, Uwe D. Treuner, Kent Amsberry, Michael Fakes, Sailesh A. Varia
  • Intermediates for the preparation of heteroaryl derivatives of monocyclic beta-lactam antiobiotics
    Patent number: 5420277
    Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring. Also described are various intermediates for the preparation of compounds of formula 1.
    Type: Grant
    Filed: November 29, 1993
    Date of Patent: May 30, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William H. Koster, Joseph E. Sundeen, Henner Straub, Peter Ermann, Uwe D. Treuner, Kent Amsberry, Michael Fakes, Sailesh A. Varia
  • Heterocyclic hydrazide derivatives of monocyclic .beta.-lactam antibiotics
    Patent number: 5318963
    Abstract: Antibacterial activity has been found in compounds of the formula.Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein: A is a bond or alkylene;Q completes a 5- or 6-membered saturated or unsaturated (including aromatic) heterocyclic ring having one or two, heteroatoms in the ring selected from nitrogen, ##STR2## sulfur or oxygen; X is attached to an available carbon atom in the heterocyclic ring and is hydrogen or oxo;Y is attached to an available carbon atom in the heterocyclic ring and is hydrogen, amino, hydroxyl, halogen, carboxamide, nitrile, or carboxyl, except that Y is not carboxyl when the bicyclic ring completed by Q is 2-quinolyl, 3-quinolyl, or quinoxalyl;and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: November 30, 1990
    Date of Patent: June 7, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter H. Ermann, Henner Straub
  • Heteroaryl derivatives of monocyclic beta-lactam antibiotics
    Patent number: 5290929
    Abstract: Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: March 1, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William H. Koster, Joseph E. Sundeen, Henner Straub, Peter Ermann, Uwe D. Treuner, Kent Amsberry, Michael Fakes, Sailesh A. Varia
  • 4-methoxy-5-methyl-pyran-3-ol natural products and derivatives thereof
    Patent number: 5270334
    Abstract: Novel antibiotic substances, including novel natural products, having the general formula ##STR1## wherein R.sub.1 and R.sub.2 are as defined herein, are disclosed. These compounds have been found to be cytochrome P450 inhibitors.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: December 14, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph O'Sullivan, Douglas W. Phillipson, Henner Straub, Peter H. Ermann
  • Substituted pyran derivatives having antiinfective activity
    Patent number: 5266593
    Abstract: Novel antibiotic substances, having the general formula ##STR1## wherein A, R.sub.1 and R.sub.2 are as defined herein.
    Type: Grant
    Filed: June 30, 1992
    Date of Patent: November 30, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter Ermann, Henner Straub, Uwe D. Treuner, Jakob-Matthias Drossard
  • Heteroaryl derivatives of monocyclic beta-lactam antibiotics
    Patent number: 5250691
    Abstract: Compounds having the formula ##STR1## exhibiting antibacterial activity.
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: October 5, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Henner Straub, Jakob-Matthias Drossard
  • 2-oxoazetidin-1-yloxy acetic acids and analogs
    Patent number: 4939253
    Abstract: Antibiotic activity is exhibited by .beta.-lactams having an ##STR1## substituent (and analogs thereof) in the 1-position and an acylamino substituent in the 3-position.
    Type: Grant
    Filed: July 21, 1983
    Date of Patent: July 3, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Henner Straub
  • 2-oxo-1-(((substituted sulfonyl)amino)-carbonyl)azetidines
    Patent number: 4801705
    Abstract: Antibacterial activity is exhibited by .beta.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: January 31, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Jakob-Matthias Drossard, Peter H. Ermann, Henner Straub, Uwe D. Treuner