Patents by Inventor Henning Dieter Mootz

Henning Dieter Mootz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ATYPICAL INTEINS
    Publication number: 20160319287
    Abstract: The present invention relates to an isolated polypeptide comprising at least one intein or at least one intein fragment of said intein, wherein said intein is a naturally split intein with a N-terminal intein fragment split after 14-60 amino acids from the intein's N-terminal end and methods of using the same.
    Type: Application
    Filed: December 12, 2014
    Publication date: November 3, 2016
    Applicants: WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER, YEDA RESEARCH & DEVELOPMENT CO. LTD.
    Inventors: Henning Dieter MOOTZ, Ilka THIEL, Gerrit VOLKMANN, Shmuel PIETROKOVSKI, Anne-Lena BACHMANN
  • Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby
    Patent number: 7279304
    Abstract: The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a polyketide synthases (PKS) or non-ribosomal peptide synthetases (NRPS) multido system catalyzes the cyclization reaction. Thioester substrates also are described that are efficiently cyclized by the method of the present invention. Additionally, macrocyclic molecules, including macrolactones and macrolactams, that are prepared by the macrocyclization methods of the invention are described.
    Type: Grant
    Filed: December 15, 2001
    Date of Patent: October 9, 2007
    Assignee: President and Fellows of Harvard College
    Inventors: Christopher Thomas Walsh, John W. Trauger, Rahul Manu Kohli, Michael D. Burkart, Mohammed A. Maraheil, Henning Dieter Mootz, Dirk Schwarzer
  • Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby
    Publication number: 20020192773
    Abstract: The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a PKS or NRPS multidomain system catalyzes the cyclization reaction. Thioester substrates also are described that are efficiently cyclized by the method of the present invention. Additionally, macrocyclic molecules, including macrolactones and macrolactams, that are prepared by the macrocyclization methods of the invention are described.
    Type: Application
    Filed: December 15, 2001
    Publication date: December 19, 2002
    Applicant: The President and Fellows of Harvard College
    Inventors: Christopher Thomas Walsh, John W. Trauger, Rahul Manu Kohli, Michael D. Burkart, Mohammed A. Maraheil, Henning Dieter Mootz, Dirk Schwarzer