Abstract: The invention relates to an ablation catheter for treatment of a patient's tissue, for example for a PVI procedure on a patient's heart, comprising an elongated catheter shaft and an ablation portion being arranged at a distal end of the catheter shaft with a plurality of electrodes accommodated along the ablation portion, wherein the ablation portion comprises at least two loop sections forming a three-dimensional spiral. In order to increase safety of ablation treatment, spare adjacent tissue (e.g. nerves, vessels, esophagus) and shorten ablation time, a pitch, or clearance of two neighboring loop sections is greater than an ionization threshold of the medium around the distal section, for example blood or gases resulted from electrolysis. The invention further relates to an operation method of such ablation catheter.

Abstract: A system for treatment of patient tissue by delivery of high-voltage pulses comprising an ablation catheter, a measurement unit and an electronic control unit (ECU). The measurement unit is configured to perform measurements using an energy source, whereby the impedance and/or current measurement values are determined as response to an alternating voltage and/or at least one voltage pulse. The ECU is configured to receive and analyze said measurement values provided by the measurement unit and determine arcing risk (AR) indexes for said electrode pairs and/or a contact uniformity (CU) value based on said impedance measurement values and/or impedances for said electrodes and/or an impedance uniformity (IU) value based on said current measurement values.

Abstract: A sensor system detects a presence or concentration of an analyte in a medium. The sensor system contains a sensor having a sensor head with a chamber. The sensor head has a permeable area through which the analyte can pass into the chamber when the sensor head contacts the medium. A cross-linked hydrogel fills the chamber, the hydrogel is configured to undergo a change in volume when contacting the analyte passed into the chamber which leads to a change in pressure in the chamber. A pressure sensor is configured to measure the pressure in the chamber for detecting the presence or concentration of the analyte.

Abstract: The invention describes an implantable pressure sensor having a housing, wherein the housing has walls and two or more pressure transfer membranes bounding an internal volume, wherein the pressure transfer membranes are not coplanar.

Abstract: An implantable pressure sensor device (100) has a housing (10) which is at least partially made of a pressure transmitting membrane (20), and which includes one or more regions which can reversibly deform while maintaining the surface area of the membrane (20) when the internal volume of the housing (10) is changed. The housing (10) has a non-circular cross-section which can deform to a more circular shape when pressure in the internal volume increases. An inner housing is preferably situated within the housing, with its exterior spaced from the interior of the housing, and has its inner volume in fluid communication with the space between the housing and inner housing.

Abstract: The disclosure relates to an ablation catheter for determining a local property of a biological tissue, said catheter having a flexible shaft, a data processing device, and an NMR sensor, which is arranged at the distal end of the shaft and is connected to the data processing device, wherein the NMR sensor comprises a first sensor element for generating a static magnetic field and a second sensor element for generating a magnetic alternating field, wherein the distal end of the shaft can be arranged adjacently to the point of the tissue to be measured, wherein the data processing device is designed to determine the local property of the tissue at this point on the basis of a signal of the NMR sensor transmitted to the data processing device. The disclosure also relates to a corresponding method.

Abstract: Embodiments of the invention include a biosensor, such as an implantable biosensor, that includes a sensor material sensitive to at least one analyte in a pressure measurement chamber coupled to a pressure sensor. In embodiments of the invention, a pressure prevailing in the pressure measurement chamber may be determined by the pressure sensor. The sensor material is coupled in the pressure measurement chamber to a compensation material, which includes a relationship between a temperature and a volume of the pressure. The relationship is opposite to a temperature-dependent change in pressure or volume of the sensor material and at least partially compensates for a cross-sensitivity-induced change in volume of the sensor material.

Abstract: A sensor system detects a presence or concentration of an analyte in a medium. The sensor system contains a sensor having a sensor head with a chamber. The sensor head has a permeable area through which the analyte can pass into the chamber when the sensor head contacts the medium. A cross-linked hydrogel fills the chamber, the hydrogel is configured to undergo a change in volume when contacting the analyte passed into the chamber which leads to a change in pressure in the chamber. A pressure sensor is configured to measure the pressure in the chamber for detecting the presence or concentration of the analyte.

Abstract: The invention describes an implantable pressure sensor having a housing, wherein the housing has walls and two or more pressure transfer membranes bounding an internal volume, wherein the pressure transfer membranes are not coplanar.

Abstract: Embodiments of the invention include a biosensor, such as an implantable biosensor, that includes a sensor material sensitive to at least one analyte in a pressure measurement chamber coupled to a pressure sensor. In embodiments of the invention, a pressure prevailing in the pressure measurement chamber may be determined by the pressure sensor. The sensor material is coupled in the pressure measurement chamber to a compensation material, which includes a relationship between a temperature and a volume of the pressure. The relationship is opposite to a temperature-dependent change in pressure or volume of the sensor material and at least partially compensates for a cross-sensitivity-induced change in volume of the sensor material.

Abstract: An implantable pressure sensor device (100) has a housing (10) which is at least partially made of a pressure transmitting membrane (20), and which includes one or more regions which can reversibly deform while maintaining the surface area of the membrane (20) when the internal volume of the housing (10) is changed. The housing (10) has a non-circular cross-section which can deform to a more circular shape when pressure in the internal volume increases. An inner housing is preferably situated within the housing, with its exterior spaced from the interior of the housing, and has its inner volume in fluid communication with the space between the housing and inner housing.