Abstract: A flowchart of a process plant is compiled by linking graphical process objects representing operator-controllable and observable facilities of the plant when planning a process plant, wherein the process in the process plant is simulated with reference to simulation models assigned to the graphical process objects during a simulation phase, where simulation models include energy consumption models that describe the electrical energy consumption of the respective facilities to be described as a function of measurable or known process variables in the plant and hence enable simulation and optimization of the automation with respect to electrical energy consumption and energy efficiency.

Abstract: Improved identification of a process anomaly in a technical facility includes training a self-organizing map using the historical process data as good states of the facility. The good states are used to determine a temporal sequence or a path of node hits and the tolerances of neuron hits. Threshold values are determined and stored for a Euclidean distance for the good states. The Euclidean distance of a current state vector to the neuron hit is checked as to whether the threshold value has been exceeded. The path determined is used to determine the neuron to be hit as long as the threshold value was not already exceeded in the check on the relevant neuron. A symptom vector from the current state vector and either the neuron hit or the neuron that is to be hit is determined.

Abstract: A flowchart of a process plant is compiled by linking graphical process objects representing operator-controllable and observable facilities of the plant when planning a process plant, wherein the process in the process plant is simulated with reference to simulation models assigned to the graphical process objects during a simulation phase, where simulation models include energy consumption models that describe the electrical energy consumption of the respective facilities to be described as a function of measurable or known process variables in the plant and hence enable simulation and optimization of the automation with respect to electrical energy consumption and energy efficiency.

Abstract: A method for operating a Coriolis mass flow rate meter and a Coriolis mass flow rate meter including an evaluation device, a measuring tube having a medium flowing therethrough and which is excited so as to perform oscillations, and at least two spaced oscillation pickups spaced apart in the longitudinal direction of the measuring tube to each generate an oscillation signal, wherein a first indicator variable based on the damping of the oscillations of the measuring tube is initially used to detect deposits in the measuring tube and if, based on the first indicator variable, increased damping is established, a second indicator variable is used, which is based on the manifestation of harmonics in the frequency spectrum of an oscillation signal such that reliable detection of deposits and therefore an indication of the state of meters and pipelines in a process engineering installation are advantageously possible.

Abstract: A method for operating a Coriolis mass flow rate meter and a Coriolis mass flow rate meter including an evaluation device, a measuring tube having a medium flowing therethrough and which is excited so as to perform oscillations, and at least two spaced oscillation pickups spaced apart in the longitudinal direction of the measuring tube to each generate an oscillation signal, wherein a first indicator variable based on the damping of the oscillations of the measuring tube is initially used to detect deposits in the measuring tube and if, based on the first indicator variable, increased damping is established, a second indicator variable is used, which is based on the manifestation of harmonics in the frequency spectrum of an oscillation signal such that reliable detection of deposits and therefore an indication of the state of meters and pipelines in a process engineering installation are advantageously possible.

Abstract: A process is disclosed for preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (I), or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (Ia) involving, as a key step, the enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone compound of formula (II).

Abstract: The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

Abstract: The invention relates to a position-finding method for determing the location of a mobile object. The features, for example received field strengths, of a plurality of base stations are measured, and the object position is located from these features, using a reference map. During an initialization process, a reference map is created which comprises a multiplicity of positions and the associated feature-dependent values. During use of the method, a plurality of position-finding processes are carried out, by means of each of which a measured feature-dependent value and from this, a located position of the object, are determined using the predetermined reference map. The predetermined reference map is in each case updated for at least some of the positions found, during which updates, the feature-dependent values are each corrected by a correction term at the support points of the reference map in a predetermined area surrounding an object position.

Abstract: The invention relates to a wireless communication device comprising an electrically operated radio module for wireless communication by receiving and/or transmitting communication signals in a transmitting and/or receiving mode; an electrically operated processor unit for controlling wireless communication via the radio module; a motion sensor for detecting movements and/or accelerations of the communication device, wherein the motion sensor outputs at least one detection signal to the processor unit in the event of the occurrence of movements and/or accelerations of a predetermined magnitude, wherein the processor unit is coupled to the motion sensor and the radio module in such a manner that it occasionally puts the radio module into the transmitting and/or receiving mode when outputting the at least one detection signal of the motion sensor.

Abstract: The invention relates to a position-finding method for d4eterming the location of a mobile object. The features, for example received field strengths, of a plurality of base stations are measured, and the object position is located from these features, using a reference map. During an initialization process, a reference map is created which comprises a multiplicity of positions and the associated feature-dependent values. During use of the method, a plurality of position-finding processes are carried out, by means of each of which a measured feature-dependent value and from this, a located position of the object, are determined using the predetermined reference map. The predetermined reference map is in each case updated for at least some of the positions found, during which updates, the feature-dependent values are each corrected by a correction term at the support points of the reference map in a predetermined area surrounding an object position.

Abstract: The present invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine nucleosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

Abstract: The invention relates to a wireless communication device comprising an electrically operated radio module for wireless communication by receiving and/or transmitting communication signals in a transmitting and/or receiving mode; an electrically operated processor unit for controlling wireless communication via the radio module; a motion sensor for detecting movements and/or accelerations of the communication device, wherein the motion sensor outputs at least one detection signal to the processor unit in the event of the occurrence of movements and/or accelerations of a predetermined magnitude, wherein the processor unit is coupled to the motion sensor and the radio module in such a manner that it occasionally. puts the radio module into the transmitting and/or receiving mode when outputting the at least one detection signal of the motion sensor.

Abstract: The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5?-methylthioadenosine phosphorylases (MTAP), 5?-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

Abstract: A process is disclosed for preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (I), or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (Ia) involving, as a key step, the enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone compound of formula (II).

Abstract: According to the invention, primary route information, which describes a primary route of a mobile unit, is determined for said mobile unit. The primary route information is then evaluated using fuzzy logic, determining the maneuver information.

Abstract: The invention relates to a method and an assembly for accumulating combined positional information for a system, in which for predetermined instants first and second respective positional information of a system are determined, using a first and a second position determination system. Respective error information for at least one part of the predetermined instants is determined using the first and second positional information. The error information is used to determine a measure for a statistical dependency between the respective error information, and said measure for a statistical dependency is used to determine the combined positional information.