Patents by Inventor Henning Steinhagen

Henning Steinhagen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluoromethyl-substituted pyrrole carboxamides iv
    Patent number: 9802921
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: October 31, 2017
    Assignee: GRUENENTHAL GMBH
    Inventors: Melanie Reich, Stefan Schunk, Florian Jakob, Henning Steinhagen, Nils Damann, Michael Haurand, Richard Hamlyn, Marc Rogers, Kathy MacKenzie
  • 3-oxo-tetrahydro-furo[3,2-b]pyrrol-4(5H)-yl) derivatives II
    Patent number: 9802947
    Abstract: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors exhibiting a pronounced CatK-inhibition, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: October 31, 2017
    Assignee: GRÜNENTHAL GMBH
    Inventors: Antonio Nardi, Paul Ratcliffe, Tobias Craan, Torsten Hertrampf, Bernhard Lesch, Henning Steinhagen
  • 3-oxo-tetrahydro-furo[3,2-B]pyrrol-4(5H)-yl) derivatives I
    Patent number: 9725459
    Abstract: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors. to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: August 8, 2017
    Assignee: GRUNENTHAL GMBH
    Inventors: Antonio Nardi, Paul Ratcliffe, Tobias Craan, Torsten Hertrampf, Bernhard Lesch, Robert Kime, Henning Steinhagen
  • Fluoromethyl-substituted pyrrole carboxamides as CaV2.2 calcium channel blockers
    Patent number: 9562036
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: February 7, 2017
    Assignee: GRÜNENTHAL GMBH
    Inventors: Melanie Reich, Stefan Schunk, Florian Jakob, Henning Steinhagen, Nils Damann, Michael Haurand, Marc Rogers, Kathy MacKenzie
  • FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES IV
    Publication number: 20160297803
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: June 14, 2016
    Publication date: October 13, 2016
    Inventors: Melanie REICH, Stefan SCHUNK, Florian JAKOB, Henning STEINHAGEN, Nils DAMANN, Michael HAURAND, Richard HAMLYN, Marc ROGERS, Kathy MACKENZIE
  • FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES AS CAV2.2 CALCIUM CHANNEL BLOCKERS
    Publication number: 20160289214
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 6, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Melanie REICH, Stefan SCHUNK, Florian JAKOB, Henning STEINHAGEN, Nils DAMANN, Michael HAURAND, Marc ROGERS, Kathy MACKENZIE
  • Fluoromethyl-substituted pyrrole carboxamides
    Patent number: 9302988
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: April 5, 2016
    Assignee: GRÜNENTHAL GMBH
    Inventors: Stefan Schunk, Melanie Reich, Henning Steinhagen, Nils Damann, Michael Haurand, Achim Kless, Philip Skone, Richard Hamlyn, Robert Kirby, Marc Rogers, Kathy Sutton
  • 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES I
    Publication number: 20150307507
    Abstract: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors. to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: April 23, 2015
    Publication date: October 29, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: ANTONIO NARDI, PAUL RATCLIFFE, TOBIAS CRAAN, TORSTEN HERTRAMPF, BERNHARD LESCH, ROBERT KIME, HENNING STEINHAGEN
  • 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES II
    Publication number: 20150307506
    Abstract: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors exhibiting a pronounced CatK-inhibition, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: April 23, 2015
    Publication date: October 29, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Antonio NARDI, Paul RATCLIFFE, Tobias CRAAN, Torsten HERTRAMPF, Bernhard LESCH, Henning STEINHAGEN
  • Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments
    Patent number: 9079906
    Abstract: The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R6, R7, R8, Q1, Q2 and Q3 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of formula I and to the use thereof as a medicament.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: July 14, 2015
    Assignee: Sanofi
    Inventors: Uwe Heinelt, Volkmar Wehner, Matthias Herrmann, Karl Schoenafinger, Henning Steinhagen, Bodo Scheiper
  • Tricyclic pyridyl-vinyl pyrroles as PAR1 inhibitors
    Patent number: 8871798
    Abstract: This disclosure relates to compounds of formula I: wherein R1, R2, R3, R4, X and Y have the meanings denoted in the disclosure. The compounds of formula I have antithrombotic activity and in particular inhibit the protease-activated receptor 1 (PAR1). The disclosure further relates to a method for producing the compound of formula I and to the use thereof as a pharmaceutical product.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: October 28, 2014
    Assignee: Sanofi
    Inventors: Karl Schoenafinger, Henning Steinhagen, Bodo Scheiper, Uwe Heinelt, Volkmar Herrmann, Matthias Herrmann
  • Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments
    Patent number: 8853206
    Abstract: The invention relates to novel compounds of formula I where X, A?, Q1, Q2, Q3, R2, R3, R4, R5, R6, R7, R8 and R9 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of formula I and to the use thereof as a medicament.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: October 7, 2014
    Assignee: Sanofi
    Inventors: Uwe Heinelt, Volkmar Wehner, Matthias Herrmann, Karl Schoenafinger, Henning Steinhagen
  • Pyridylvinylpyrazoloquinolines as PAR1 inhibitors
    Patent number: 8791133
    Abstract: The disclosure relates to compounds of formula I: wherein the groups R1, R2, R3, R4, R5 and X are as defined in the disclosure, having antithrombotic activity, which in particular inhibits the protease-activated receptor 1 (PAR1). The disclosure further relates to methods for producing the same and to the use thereof as a pharmaceutical product.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: July 29, 2014
    Assignee: Sanofi
    Inventors: Karl Schoenafinager, Henning Steinhagen, Bodo Scheiper, Uwe Heinelt, Volkmar Wehner, Matthias Herrmann, Jacques Mauger, Pavel Safar
  • FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES
    Publication number: 20140066426
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: August 29, 2013
    Publication date: March 6, 2014
    Inventors: Stefan SCHUNK, Melanie REICH, Henning STEINHAGEN, Nils DAMANN, Michael HAURAND, Achim KLESS, Philip SKONE, Richard HAMLYN, Robert KIRBY, Marc ROGERS, Kathy SUTTON
  • Imidazopyridazines as PAR1 inhibitors, production thereof, and use as medicaments
    Patent number: 8598177
    Abstract: The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R6, R7, R8, R9, Q1, Q2 and Q3 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of formula I and to the use thereof as a medicament.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: December 3, 2013
    Assignee: Sanofi
    Inventors: Uwe Heinelt, Volkmar Wehner, Matthias Herrmann, Karl Schoenafinger, Henning Steinhagen
  • Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals
    Patent number: 8580813
    Abstract: The present invention relates to cyclic azaindole-3-carboxamides of the formula I, wherein A, R, R10, R20, R30, R40, Y1, Y2, Y3, Y4, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: November 12, 2013
    Assignee: Sanofi
    Inventors: Henning Steinhagen, Bodo Scheiper, Hans Matter, Gary Mccort
  • SFderivatives as PAR1 inhibitors, production thereof, and use as medicaments
    Patent number: 8466169
    Abstract: The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R9, Ar, Q1, Q2 and Q3 are each as defined below. The compounds of the formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of the formula I and to the use thereof as a medicament.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: June 18, 2013
    Assignee: Sanofi
    Inventors: Uwe Heinelt, Volkmar Wehner, Matthias Herrmann, Karl Schoenafinger, Henning Steinhagen
  • Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals
    Patent number: 8415336
    Abstract: The present invention relates to cyclic indolizinecarboxamides and azaindolizinecarboxamides of the formulae Ia and Ib, wherein R, Ra, R10, R20, R30, R40, Y, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: April 9, 2013
    Assignee: Sanofi
    Inventors: Henning Steinhagen, Bodo Scheiper, Hans Matter, Gary McCort, Guillaume Begis, Pascale Goberville, Berangere Thiers
  • CYCLIC (AZA)INDOLIZINECARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
    Publication number: 20120232081
    Abstract: The present invention relates to cyclic indolizinecarboxamides and azaindolizinecarboxamides of the formulae Ia and Ib, wherein R, Ra, R10, R20, R30, R40, Y, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them.
    Type: Application
    Filed: January 19, 2012
    Publication date: September 13, 2012
    Applicant: SANOFI
    Inventors: Henning STEINHAGEN, Bodo SCHEIPER, Hans MATTER, Gary MCCORT, Guillaume BEGIS, Pascale GOBERVILLE, Berangere THIERS
  • Tartrate derivatives for use as coagulation factor IXa inhibitors
    Patent number: 8263621
    Abstract: The invention relates to the compounds of formula I having antithrombotic activity which especially inhibits blood clotting factor IXa, to methods for producing the same and to the use thereof as drugs.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: September 11, 2012
    Assignee: Sanofi
    Inventors: Henning Steinhagen, Markus Follmann, Jochen Goerlitzer, Herman Schreuder