Patents by Inventor Henning WEHRS
Henning WEHRS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240087872Abstract: A method of determining an expected response to injecting a beam of ions of a species of interest into a static field mass filter of a mass spectrometer including a mass analyser is provided. The method includes: measuring an intensity of ions injected into the static field mass filter for various combinations of test ion species, test magnetic field strengths, and test electric field strengths; determining electric field strengths corresponding to an intensity equal to a first and a second fraction of the measured peak intensity; based on a predetermined relationship between magnetic field strength, electric field strength and centre mass of the static field mass filter, determining mass values corresponding to the determined electric field strengths; and interpolating, from said mass values and for each ion species and for at least one of the test magnetic field strengths, expected mass values for an ion species of interest.Type: ApplicationFiled: September 13, 2023Publication date: March 14, 2024Applicant: Thermo Fisher Scientific (Bremen) GmbHInventors: Henning Wehrs, Joachim Hinrichs
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Publication number: 20240086587Abstract: A computer-implemented method of simulating a mass filter, which has a bandpass characteristic, of a mass spectrometer includes: receiving a first candidate magnetic field strength and a first candidate electric field strength of the mass filter; based on the received first candidate magnetic and electric field strengths, determining a corresponding centre mass of the mass filter; based on the received first candidate magnetic and electric field strengths, determining the width of a passband of the bandpass characteristic; and determining at least one of a lower or an upper bound of the passband of the bandpass characteristic of the mass filter, the determining of the upper bound including adding a first predetermined fraction of the determined width of the passband to the determined centre mass and the determining of the lower bound comprising subtracting a second predetermined fraction of the determined width of the passband from the determined centre mass.Type: ApplicationFiled: September 13, 2023Publication date: March 14, 2024Applicant: Thermo Fisher Scientific (Bremen) GmbHInventors: Henning Wehrs, Jan Schuessler, Johannes Schwieters
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Publication number: 20240087863Abstract: A method of tuning a static field mass filter of a mass spectrometer, the static field mass filter having a first Wien filter and a second Wien filter. The method comprises injecting a beam of ions into the static field mass filter, applying a magnetic and an electric field in the first and second Wien filters, adjusting a second lens of the filter.Type: ApplicationFiled: September 13, 2023Publication date: March 14, 2024Applicant: Thermo Fisher Scientific (Bremen) GmbHInventors: Henning Wehrs, Markus Pfeifer, Joachim Hinrichs, Grant Craig
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Patent number: 11862450Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises a collision cell defining an ion optical axis along which ions may pass, electrodes comprising a set of parallel poles (11A, 11B, 11C) arranged in the collision cell, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is arranged for switching between a first operation mode in which the collision cell is pressurized and a second operation mode in which the collision cell is substantially evacuated. The ion optical arrangement is further arranged for producing a radio frequency electric focusing field in the first operation mode and a static electric focusing field in the second operation mode.Type: GrantFiled: May 19, 2020Date of Patent: January 2, 2024Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Henning Wehrs, Johannes Schwieters, Gerhard Jung
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Publication number: 20230343571Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises electrodes (11, 12, 14) comprising a multipole arrangement defining an ion optical axis, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is configured for producing a radio frequency electric focusing field for focusing ions on the ion optical axis. The radio frequency electric focusing field has a varying frequency so as to reduce any mass dependence of ion trajectories through the ion optical arrangement. The ion optical arrangement may further he configured for producing a static electric field in response to a DC bias voltage applied to the multipole arrangement. A superimposed varying electric field may be produced by superimposing an AC voltage upon the DC bias voltage.Type: ApplicationFiled: June 22, 2023Publication date: October 26, 2023Applicant: Thermo Fisher Scientific (Bremen) GmbHInventors: Henning WEHRS, Johannes SCHWIETERS, Gerhard JUNG
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Patent number: 11728155Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises electrodes (11, 12, 14) comprising a multipole arrangement defining an ion optical axis, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is configured for producing a radio frequency electric focusing field for focusing ions on the ion optical axis. The radio frequency electric focusing field has a varying frequency so as to reduce any mass dependence of ion trajectories through the ion optical arrangement. The ion optical arrangement may further be configured for producing a static electric field in response to a DC bias voltage applied to the multipole arrangement. A superimposed varying electric field may be produced by superimposing an AC voltage upon the DC bias voltage.Type: GrantFiled: May 19, 2020Date of Patent: August 15, 2023Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Henning Wehrs, Johannes Schwieters, Gerhard Jung
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Publication number: 20220230863Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises electrodes (11) defining an ion optical path, a housing (18) for accommodating the electrodes, a voltage source for providing voltages to the electrodes to produce electric fields, and a valve for allowing gas to enter and/or leave the housing. The valve comprises an electrostatic mechanism and/or a pneumatic mechanism. The electrostatic mechanism may comprise a flexible foil (30, 31) configured for covering at least one opening (16) in the ion optical arrangement when a first voltage is applied and being spaced apart from the at least one opening when a second voltage is applied. The pneumatic mechanism may comprise a Bourdon tube.Type: ApplicationFiled: May 19, 2020Publication date: July 21, 2022Applicant: Thermo Fisher Scientific (Bremen) GmbHInventor: Henning WEHRS
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Publication number: 20220216043Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises electrodes (11, 12, 14) comprising a multipole arrangement defining an ion optical axis, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is configured for producing a radio frequency electric focusing field for focusing ions on the ion optical axis. The radio frequency electric focusing field has a varying frequency so as to reduce any mass dependence of ion trajectories through the ion optical arrangement. The ion optical arrangement may further be configured for producing a static electric field in response to a DC bias voltage applied to the multipole arrangement. A superimposed varying electric field may be produced by superimposing an AC voltage upon the DC bias voltage.Type: ApplicationFiled: May 19, 2020Publication date: July 7, 2022Applicant: Thermo Fisher Scientific (Bremen) GmbHInventors: Henning WEHRS, Johannes SCHWIETERS, Gerhard JUNG
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Publication number: 20220216044Abstract: An ion optical arrangement (1) for use in a mass spectrometer comprises a collision cell defining an ion optical axis along which ions may pass, electrodes comprising a set of parallel poles (11A, 11B, 11C) arranged in the collision cell, and a voltage source for providing voltages to the electrodes to produce electric fields. The ion optical arrangement is arranged for switching between a first operation mode in which the collision cell is pressurized and a second operation mode in which the collision cell is substantially evacuated. The ion optical arrangement is further arranged for producing a radio frequency electric focusing field in the first operation mode and a static electric focusing field in the second operation mode.Type: ApplicationFiled: May 19, 2020Publication date: July 7, 2022Inventors: Henning WEHRS, Johannes SCHWIETERS, Gerhard JUNG
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Patent number: 11328915Abstract: A mass spectrometry method comprising steps of generating an ion beam from an ion source; directing the ion beam into a collision cell; introducing into the collision cell through a gas inlet on the collision cell a charge-neutral analyte gas or reaction gas; ionizing the analyte gas or reaction gas in the collision cell by means of collisions between the analyte gas or reaction gas and the ion beam; transmitting ions from the ionized analyte gas or reaction gas from the collision cell into a mass analyzer; and mass analyzing the transmitted ions of the ionized analyte or reaction gas. The methods can be applied in isotope ratio mass spectrometry to determine the isotope abundance or isotope ratio of a reaction gas used in mass shift reactions between the gas and sample ions, to determine a corrected isotope abundance or ratio of the sample ions.Type: GrantFiled: April 23, 2020Date of Patent: May 10, 2022Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Johannes Schwieters, Henning Wehrs, Jamie Lewis
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Publication number: 20200251322Abstract: A mass spectrometry method comprising steps of generating an ion beam from an ion source; directing the ion beam into a collision cell; introducing into the collision cell through a gas inlet on the collision cell a charge-neutral analyte gas or reaction gas; ionizing the analyte gas or reaction gas in the collision cell by means of collisions between the analyte gas or reaction gas and the ion beam; transmitting ions from the ionized analyte gas or reaction gas from the collision cell into a mass analyzer; and mass analyzing the transmitted ions of the ionized analyte or reaction gas. The methods can be applied in isotope ratio mass spectrometry to determine the isotope abundance or isotope ratio of a reaction gas used in mass shift reactions between the gas and sample ions, to determine a corrected isotope abundance or ratio of the sample ions.Type: ApplicationFiled: April 23, 2020Publication date: August 6, 2020Inventors: Johannes Schweiters, Henning Wehrs, Jamie Lewis
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Patent number: 10699890Abstract: Methods of determining isobaric interference during mass analysis in a mass spectrometer are provided. The methods comprise comparing interference-free reaction profiles of a chemical species to reaction profiles of the same chemical species that may comprise isobaric interference, wherein a determination of a difference between the profiles is an indication of isobaric interference being present. Methods of quantifying isobaric interference are also provided, including methods of correcting isotope ratios determined in the presence of isobaric interference.Type: GrantFiled: March 5, 2019Date of Patent: June 30, 2020Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Johannes Schwieters, Henning Wehrs
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Patent number: 10651023Abstract: A mass spectrometry method comprising steps of generating an ion beam from an ion source; directing the ion beam into a collision cell; introducing into the collision cell through a gas inlet on the collision cell a charge-neutral analyte gas or reaction gas; ionizing the analyte gas or reaction gas in the collision cell by means of collisions between the analyte gas or reaction gas and the ion beam; transmitting ions from the ionized analyte gas or reaction gas from the collision cell into a mass analyzer; and mass analyzing the transmitted ions of the ionized analyte or reaction gas. The methods can be applied in isotope ratio mass spectrometry to determine the isotope abundance or isotope ratio of a reaction gas used in mass shift reactions between the gas and sample ions, to determine a corrected isotope abundance or ratio of the sample ions.Type: GrantFiled: February 23, 2018Date of Patent: May 12, 2020Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Johannes Schwieters, Henning Wehrs, Jamie Lewis
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Publication number: 20190221416Abstract: Methods of determining isobaric interference during mass analysis in a mass spectrometer are provided. The methods comprise comparing interference-free reaction profiles of a chemical species to reaction profiles of the same chemical species that may comprise isobaric interference, wherein a determination of a difference between the profiles is an indication of isobaric interference being present. Methods of quantifying isobaric interference are also provided, including methods of correcting isotope ratios determined in the presence of isobaric interference.Type: ApplicationFiled: March 5, 2019Publication date: July 18, 2019Inventors: Johannes SCHWIETERS, Henning WEHRS
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Patent number: 10290486Abstract: Methods of determining isobaric interference during mass analysis in a mass spectrometer are provided. The methods comprise comparing interference-free reaction profiles of a chemical species to reaction profiles of the same chemical species that may comprise isobaric interference, wherein a determination of a difference between the profiles is an indication of isobaric interference being present. Methods of quantifying isobaric interference are also provided, including methods of correcting isotope ratios determined in the presence of isobaric interference.Type: GrantFiled: December 18, 2017Date of Patent: May 14, 2019Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Johannes Schwieters, Henning Wehrs
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Publication number: 20180240662Abstract: A mass spectrometry method comprising steps of generating an ion beam from an ion source; directing the ion beam into a collision cell; introducing into the collision cell through a gas inlet on the collision cell a charge-neutral analyte gas or reaction gas; ionizing the analyte gas or reaction gas in the collision cell by means of collisions between the analyte gas or reaction gas and the ion beam; transmitting ions from the ionized analyte gas or reaction gas from the collision cell into a mass analyzer; and mass analyzing the transmitted ions of the ionized analyte or reaction gas. The methods can be applied in isotope ratio mass spectrometry to determine the isotope abundance or isotope ratio of a reaction gas used in mass shift reactions between the gas and sample ions, to determine a corrected isotope abundance or ratio of the sample ions.Type: ApplicationFiled: February 23, 2018Publication date: August 23, 2018Inventors: Johannes SCHWIETERS, Henning WEHRS, Jamie LEWIS
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Patent number: 10056241Abstract: Disclosed is a method of inductively coupled plasma mass spectrometry (ICP-MS), comprising steps of introducing at least one sample comprising at least one sample species, and at least one reactive species, into an inductively coupled plasma source, such that at least one molecular adduct ion of the at least one reactive species and the at least one sample species is formed; transferring the at least one molecular adduct ion into a collision cell that is arranged between the inductively coupled plasma source and at least one mass analyzer, transferring the at least one molecular adduct ion, or a product thereof, into the at least one mass analyzer, and analyzing the mass of the at least one molecular adduct ion, or the product thereof, in the at least one mass analyzer. Also disclosed is a mass spectrometer that is adapted to perform the method.Type: GrantFiled: October 31, 2016Date of Patent: August 21, 2018Assignee: Thermo Fisher Scientific (Bremen) GmbHInventor: Henning Wehrs
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Publication number: 20180174814Abstract: Methods of determining isobaric interference during mass analysis in a mass spectrometer are provided. The methods comprise comparing interference-free reaction profiles of a chemical species to reaction profiles of the same chemical species that may comprise isobaric interference, wherein a determination of a difference between the profiles is an indication of isobaric interference being present. Methods of quantifying isobaric interference are also provided, including methods of correcting isotope ratios determined in the presence of isobaric interference.Type: ApplicationFiled: December 18, 2017Publication date: June 21, 2018Inventors: Johannes SCHWIETERS, Henning WEHRS
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Publication number: 20170140914Abstract: Disclosed is a method of inductively coupled plasma mass spectrometry (ICP-MS), comprising steps of introducing at least one sample comprising at least one sample species, and at least one reactive species, into an inductively coupled plasma source, such that at least one molecular adduct ion of the at least one reactive species and the at least one sample species is formed; transferring the at least one molecular adduct ion into a collision cell that is arranged between the inductively coupled plasma source and at least one mass analyzer, transferring the at least one molecular adduct ion, or a product thereof, into the at least one mass analyzer, and analyzing the mass of the at least one molecular adduct ion, or the product thereof, in the at least one mass analyzer. Also disclosed is a mass spectrometer that is adapted to perform the method.Type: ApplicationFiled: October 31, 2016Publication date: May 18, 2017Inventor: Henning WEHRS