Patents by Inventor Henning Weigt

Henning Weigt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives for use as BCRP inhibitors in therapeutic treatments
    Patent number: 10975079
    Abstract: The present invention relates to 5-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives of the general formula (I) or pharmaceutically acceptable salts or propharmacons thereof for use as BCRP inhibitors, wherein at least one hydrogen atom in at least one of the phenyl groups A and B is substituted by a substituent RH, which has a Hammett constant ?p greater than 0.23. For corresponding compounds, surprisingly a particularly high inhibitory activity against BCRP has been discovered which can be exploited for suppressing the multidrug resistance modulator BCRP, thus providing an improvement in efficacy of BCRP affected drugs. This has useful implications for cancer and HIV treatment.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: April 13, 2021
    Assignee: Scandion Oncology A/S
    Inventors: Steffen Rump, Henning Weigt
  • 4-AMINO-3-PHENYLAMINO-6-PHENYLPYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES FOR USE AS BCRP INHIBITORS IN THERAPEUTIC TREATMENTS
    Publication number: 20180044341
    Abstract: The present invention relates to 5-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives of the general formula (I) or pharmaceutically acceptable salts or propharmacons thereof for use as BCRP inhibitors, wherein at least one hydrogen atom in at least one of the phenyl groups A and B is substituted by a substituent RH, which has a Hammett constant ?p greater than 0.23. For corresponding compounds, surprisingly a particularly high inhibitory activity against BCRP has been discovered which can be exploited for suppressing the multidrug resistance modulator BCRP, thus providing an improvement in efficacy of BCRP affected drugs. This has useful implications for cancer and HIV treatment.
    Type: Application
    Filed: February 24, 2016
    Publication date: February 15, 2018
    Inventors: Steffen RUMP, Henning WEIGT
  • Therapeutical composition containing dentritic cells and use thereof
    Patent number: 8415152
    Abstract: The present invention relates to a method for the preparation of a therapeutical composition, in particular, the present invention relates to a method for treating dendritic cells with a combination of at least one interferon gamma receptor agonist and at least one toll like receptor 2 and/or TLR 6 agonist and using these pretreated dendritic cells for the preparation of a therapeutical composition. Moreover, the present invention relates to a therapeutical composition containing dendritic cells and the use thereof for the treatment of various diseases and disorders.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: April 9, 2013
    Assignee: Helmholtz-Zentrum für Infektionsforschung GmbH
    Inventors: Peter F. Muhlradt, Armin Braun, Norbert Krug, Henning Weigt
  • Therapeutical Composition Containing Dentritic Cells and use Thereof
    Publication number: 20110070250
    Abstract: The present invention relates to a method for the preparation of a therapeutical composition, in particular, the present invention relates to a method for treating dendritic cells with a combination of at least one interferon gamma receptor agonist and at least one toll like receptor 2 and/or TLR 6 agonist and using these pretreated dendritic cells for the preparation of a therapeutical composition. Moreover, the present invention relates to a therapeutical composition containing dendritic cells and the use thereof for the treatment of various diseases and disorders.
    Type: Application
    Filed: September 3, 2010
    Publication date: March 24, 2011
    Inventors: Peter F. Muhlradt, Armin Braun, Norbert Krug, Henning Weigt
  • Therapeutical Composition Containing Dentritic Cells And Use Thereof
    Publication number: 20070203185
    Abstract: The present invention relates to a method for the preparation of a therapeutical composition, in particular, the present invention relates to a method for treating dendritic cells with a combination of at least one interferon gamma receptor agonist and at least one toll like receptor 2 and/or TLR 6 agonist and using these pretreated dendritic cells for the preparation of a therapeutical composition. Moreover, the present invention relates to a therapeutical composition containing dendritic cells and the use thereof for the treatment of various diseases and disorders.
    Type: Application
    Filed: June 3, 2004
    Publication date: August 30, 2007
    Inventors: Peter Muhlradt, Armin Braun, Norbert Krug, Henning Weigt