Patents by Inventor Henri AROLA

Henri AROLA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230400461
    Abstract: The invention relates to a method for determining a target molecule in a sample. Also, the invention relates to a Förster resonance energy transfer (FRET, fluorescence resonance energy transfer) pair, recombinant antibodies, or antigen binding fragments thereof that bind Staphylococcus aureus Enterotoxin A and a test kit comprising the FRET pair, antibody or antigen binding fragment. Furthermore, the present invention relates to an isolated nucleic acid molecule comprising a nucleotide sequence that encodes the recombinant antibody or antigen binding fragment, and an expression vector comprising said nucleic acid molecule. Still, the invention relates to use of the FRET pair or the recombinant antibody or an antigen binding fragment thereof for determining a target molecule such as Staphylococcus aureus Enterotoxin A in a sample. And still, the invention relates to a method of producing the antibody or antigen binding fragment.
    Type: Application
    Filed: January 7, 2022
    Publication date: December 14, 2023
    Inventors: Tarja NEVANEN, Sirpa JYLHÄ, Henri AROLA
  • Patent number: 11578125
    Abstract: The present invention relates to the fields of antibodies, antigen binding fragments and immunodiagnostics. Specifically, the invention relates to a recombinant anti-body or antigen binding fragment for binding thyroid hormone T4 (thyroxine) and halogenated bisphenol A. Also, the present invention relates to an isolated nucleic acid molecule comprising a nucleotide sequence that encodes the recombinant antibody or antigen binding fragment of the present invention, as well as an ex-pression vector and host cell comprising the nucleic acid molecule of the present invention. Still, the present invention relates to a method of producing a recombi-nant antibody or antigen binding fragment for binding T4 thyroid hormone and hal-ogenated bisphenol A, a test kit and an immunoassay comprising the recombinant antibody or antigen binding fragment of the present invention, and a method for determining T4 thyroid hormone and/or halogenated bisphenol A levels in a sam-ple of a subject.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: February 14, 2023
    Assignees: Teknologian tutkimuskeskus VTT Oy, Politecnico di Milano
    Inventors: Tarja Nevanen, Henri Arola, Antti Tullila, Juha Rouvinen, Tarja Parkkinen, Pierangelo Metrangolo
  • Publication number: 20220214336
    Abstract: The present invention relates to the fields of life sciences, polypeptide analysis and polypeptide discovery methods. Also, the present invention concerns detection methods of target molecules in a sample. Specifically, the invention relates to a method of screening polypeptides capable of binding a target molecule and a method of analyzing or pretreating a sample. Also, the present invention relates to a kit for carrying out methods of the present invention as well as to a polypeptide, antibody or antigen binding fragment capable of binding target molecules screened or obtained by the method of the present invention.
    Type: Application
    Filed: January 28, 2020
    Publication date: July 7, 2022
    Applicant: Teknologian tutkimuskeskus VTT Oy
    Inventors: Antti TULLILIA, Tarja NEVANEN, Henri AROLA, Heli NYGREN
  • Publication number: 20210230270
    Abstract: The present invention relates to the fields of antibodies, antigen binding fragments and immunodiagnostics. Specifically, the invention relates to a recombinant anti-body or antigen binding fragment for binding thyroid hormone T4 (thyroxine) and halogenated bisphenol A. Also, the present invention relates to an isolated nucleic acid molecule comprising a nucleotide sequence that encodes the recombinant antibody or antigen binding fragment of the present invention, as well as an ex-pression vector and host cell comprising the nucleic acid molecule of the present invention. Still, the present invention relates to a method of producing a recombi-nant antibody or antigen binding fragment for binding T4 thyroid hormone and hal-ogenated bisphenol A, a test kit and an immunoassay comprising the recombinant antibody or antigen binding fragment of the present invention, and a method for determining T4 thyroid hormone and/or halogenated bisphenol A levels in a sam-ple of a subject.
    Type: Application
    Filed: May 28, 2019
    Publication date: July 29, 2021
    Applicants: Teknologian tutkimuskeskus VTT Oy, Politecnico di Milano
    Inventors: Tarja NEVANEN, Henri AROLA, Antti TULLILA, Juha ROUVINEN, Tarja PARKKINEN, Pierangelo METRANGOLO