Patents by Inventor Henri Brunengraber

Henri Brunengraber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Medical uses of pyruvates
    Patent number: 6086789
    Abstract: A pyruvate compound suitable for cosmetically or dermatologically administering to the skin and for use in treating diabetic ketosis or other medical treatments. The compound includes a pyruvate selected from the group of pyruvate thioester, dihydroxyacetonepyruvate, and an ester of pyruvate and a sugar or a polyol.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: July 11, 2000
    Assignee: Case Western Reserve University
    Inventors: Henri Brunengraber, Catherine Bomont, France David, Peter T. Hallowell, Kevin D. Cooper, Takhar Kasoumov
  • Pyruvate compounds and methods for use thereof
    Patent number: 5968727
    Abstract: The invention comprises a novel pyruvate compound for the treatment of prevention of reperfusion injury following ischemia, diabetic effects, cholesterol levels, injured organs ethanol intoxication oras s foodstuff. The novel pyruvate compound is particularly a puruvate thiolester, a glucerol-pyruvate ester or a dihydoxyacetone-pyruvate ester.
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: October 19, 1999
    Assignee: Case Western Reserve University
    Inventors: Henri Brunengraber, Catherine Bomont, France David, Peter T. Hallowell
  • Pyruvate compounds and methods for use thereof
    Patent number: 5876916
    Abstract: The invention comprises a novel pyruvate compound for the treatment or prevention of reperfusion injury following ischemia, diabetic effects, cholesterol levels, injured organs, ethanol intoxication or as a foodstuff. The novel pyruvate compound is particularly a pyruvate thiolester, a glycerol-pyruvate ester or a dihydoxyacetone-pyruvate ester.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: March 2, 1999
    Assignee: Case Western Reserve University
    Inventors: Henri Brunengraber, Catherine Bomont, France David, Peter T. Hallowell
  • Pyruvate thiolester for the prevention of reperfusion injury
    Patent number: 5667962
    Abstract: The invention comprises a novel pyruvate compound for the treatment or prevention of reperfusion injury following ischemia. The novel pyruvate compound is particularly a pyruvate thiolester. Preferably, the thiol is selected from a cysteine or a methionine amino acid. In a particularly preferred form, the compound is an N-acetyl ethyl ester of the cysteine or methionine amino acid.
    Type: Grant
    Filed: March 18, 1996
    Date of Patent: September 16, 1997
    Assignee: Case Western Reserve University
    Inventors: Henri Brunengraber, Hermann Dugas, Khadija Quinze, Catherine Bomont
  • Composition for parenteral and oral nutrition
    Patent number: 5126373
    Abstract: In accordance with the present invention, there is provided a composition for parenteral and oral nutrition, which comprises a compound of Formula I: ##STR1## wherein R.sub.2 is methyl or ethyl;R.sub.3 and R.sub.4 are independently ##STR2## or H, and X is --C.dbd.O or --HC--OH,and mixtures thereof,or pharmaceutically acceptable derivative, diastereoisomers or optical isomers thereof, in association with a pharmaceutically acceptable carrier, with the proviso that R.sub.3 and R.sub.4 cannot be H at the same time.
    Type: Grant
    Filed: December 6, 1990
    Date of Patent: June 30, 1992
    Inventors: Henri Brunengraber, Sylvain Desrochers, Bernard R. Landau
  • Use of 1,3-butanediol acetoacetate in parenteral oral nutrition
    Patent number: 4997976
    Abstract: Compositions for parenteral nutrition comprising a nutritionally effective amount of a compound of the following formula: ##STR1## R.sup.2 is methyl or ethyl, and R.sup.3 and R.sup.4 are ##STR2## or H, and X is --C.dbd.O or --HC--OH,or a compound of the following formula: ##STR3## wherein R.sup.2 is methyl or ethyl, andX is --C.dbd.O or --C--OH,or mixtures thereof in association with a carrier.
    Type: Grant
    Filed: November 15, 1988
    Date of Patent: March 5, 1991
    Inventors: Henri Brunengraber, Sylvain Desrochers, Bernard R. Landau