Patents by Inventor Henri Ramuz

Henri Ramuz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxadiazolotriazine derivatives
    Patent number: 4276417
    Abstract: Oxadiazolotriazine derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as hereinafter set forth, are described. The compounds of formula I are useful in the treatment of vascular-condition hypertension or also as vasodilators in the case of peripheral blood supply disorders.
    Type: Grant
    Filed: July 26, 1979
    Date of Patent: June 30, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Claude Muller, Henri Ramuz
  • Process for the preparation of oxadiazolopyrimidine derivatives
    Patent number: 4256886
    Abstract: A process for preparing oxadiazolopyrimidines of the formula ##STR1## wherein R is alkyl or alkoxyalkyl, by reacting a compound of the formula ##STR2## wherein R is as set forth above, with phosgene, is described.
    Type: Grant
    Filed: February 21, 1980
    Date of Patent: March 17, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Claude Muller, Henri Ramuz
  • 2-Imino-imidazolidine derivatives
    Patent number: 4244957
    Abstract: 2-Imino-imidazolidine derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as hereinafter set forth, and pharmaceutically acceptable acid addition salts thereof, are described. The 2-imino-imidazolidine derivatives are useful in the treatment of hypertension.
    Type: Grant
    Filed: November 6, 1978
    Date of Patent: January 13, 1981
    Assignee: Hoffman-La Roche Inc.
    Inventor: Henri Ramuz
  • Process for the preparation of oxadiazolopyrimidine derivatives
    Patent number: 4220772
    Abstract: A process for preparing oxadiazolopyrimidines of the formula ##STR1## wherein R is alkyl or alkoxyalkyl, by reacting a compound of the formula ##STR2## wherein R is as set forth above, with phosgene, is described.
    Type: Grant
    Filed: July 6, 1979
    Date of Patent: September 2, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Claude Muller, Henri Ramuz
  • 6-[3,6-Dihydro-1(2H)-pyridyl]-pyrimidine-3-oxides
    Patent number: 4182867
    Abstract: Alkyl or alkoxyalkyl 5-[3,6-dihydro-1(2H)-pyridyl]-2-oxo-2H-[1,2,4]-oxadiazolo-[2,3-a]pyrimidin e-7-carbamates, prepared, inter alia, from the corresponding 6-[3,6-dihydro-1(2H)-pyridyl]-2,4-pyrimidine-dicarbamate-3-oxide, are described. The end products are useful in the treatment of vascular-conditioned hypertension or as vasodilators in the case of peripheral blood supply disorders.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: January 8, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Claude Muller, Henri Ramuz
  • 2,4-Pyrimidine-dicarbamate-3-oxides
    Patent number: 4176119
    Abstract: Oxadiazolopyrimidine derivatives of the formula ##STR1## wherein R and R.sub.1 are as hereinafter described, prepared, inter alia, by cyclizing a compound of the formula ##STR2## wherein R and R.sub.1 are as hereinafter described. The end products are useful in the treatment of vascular-conditioned hypertension or as vasodilators in the case of peripheral blood supply disorders.
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: November 27, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Claude Muller, Henri Ramuz
  • 6-Chloro-2,4-pyrimidine-dicarbamate-3-oxides
    Patent number: 4175189
    Abstract: Alkyl or alkoxyalkyl 5-[3,6-dihydro-1(2H)-pyridyl]-2-oxo-2H-[1,2,4]-oxadiazolo-[2,3-a]pyrimidin e-7-carbamates, prepared, inter alia, from the corresponding 6-[3,6-dihydro-1(2H)-pyridyl]-2,4-pyrimidine-dicarbamate-3-oxide, are described. The end products are useful in the treatment of vascular-conditioned hypertension or as vasodilators in the case of peripheral blood supply disorders.
    Type: Grant
    Filed: December 22, 1978
    Date of Patent: November 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Claude Muller, Henri Ramuz
  • 6-Chloro-2,4-pyrimidine-dicarbamate-3-oxides
    Patent number: 4175190
    Abstract: Oxadiazolopyrimidine derivatives of the formula ##STR1## wherein R and R.sub.1 are as hereinafter described, prepared, inter alia, by cyclizing a compound of the formula ##STR2## wherein R and R.sub.1 are as hereinafter described. The end products are useful in the treatment of vascular-conditioned hypertension or as vasodilators in the case of peripheral blood supply disorders.
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: November 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Claude Muller, Henri Ramuz
  • Substituted oxadiazolopyrimidines
    Patent number: 4150131
    Abstract: Oxadiazolopyrimidine derivatives of the formula ##STR1## wherein R and R.sub.1 are as hereinafter described, prepared, inter alia, by cyclizing a compound of the formula ##STR2## wherein R and R.sub.1 are as hereinafter described. The end products are useful in the treatment of vascular-conditioned hypertension or as vasodilators in the case of peripheral blood supply disorders.
    Type: Grant
    Filed: January 27, 1978
    Date of Patent: April 17, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Claude Muller, Henri Ramuz
  • Oxadiazolopyrimidine derivatives
    Patent number: 4150132
    Abstract: Alkyl or alkoxyalkyl 5-[3,6-dihydro-1(2H)-pyridyl]-2-oxo-2H-[1,2,4]-oxadiazolo-[2,3-a]primidine -7-carbamates, prepared, inter alia, from the corresponding 6-[3,6-dihydro-1(2H)-pyridyl]-2,4-pyrimidine-dicarbamate-3-oxide, are described. The end products are useful in the treatment of vascular-conditioned hypertension or as vasodilators in the case of peripheral blood supply disorders.
    Type: Grant
    Filed: January 27, 1978
    Date of Patent: April 17, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Claude Muller, Henri Ramuz
  • Sulphur containing derivatives
    Patent number: 4127588
    Abstract: A novel class of dithiane and disulfone compound is described. These compounds are pharmaceutically active as coronary dilating agents and thus can be used therapeutically in cases of insufficient cardiac blood supply, i.e., in the treatment of angina pectoris. A preferred compound is N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-N-methyl-m-dithiane-2-p ropylamine-1,1-3,3-tetraoxide.
    Type: Grant
    Filed: November 21, 1977
    Date of Patent: November 28, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Henri Ramuz
  • Sulphur containing derivatives
    Patent number: 4073797
    Abstract: A novel class of dithiane and disulfone compound is described. These compounds are pharmaceutically active as coronary dilating agents and thus can be used therapeutically in cases of insufficient cardiac blood supply, i.e., in the treatment of angina pectoris. A preferred compound is N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-N-methyl-m-dithiane-2-p ropylamine-1,1-3,3-tetraoxide.
    Type: Grant
    Filed: October 1, 1976
    Date of Patent: February 14, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Henri Ramuz
  • Sulphur containing derivatives
    Patent number: 4003914
    Abstract: A novel class of dithiane and disulfone compound is described. These compounds are pharmaceutically active as coronary dilating agents and thus can be used therapeutically in cases of insufficient cardiac blood supply, i.e., in the treatment of angina pectoris. A preferred compound is N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-N-methyl-m-dithiane-2-p ropylamine-1,1-3,3-tetraoxide.
    Type: Grant
    Filed: December 16, 1974
    Date of Patent: January 18, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Henri Ramuz