Patents by Inventor Henri ROCHE

Henri ROCHE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Signature for the diagnosis of cancer aggressiveness and genetic instability
    Patent number: 8865408
    Abstract: The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of the patient. The method includes measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in the patient cancer sample, calculating an expression level ratio of the expression level of POLQ to the expression of the control gene in the patient cancer sample, comparing the expression level ratio to a corresponding threshold value, and diagnosing cancer aggressiveness and genetic instability if the POLQ expression level ratio is superior to a corresponding threshold value. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: October 21, 2014
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Paul Sabatier Toulouse III, Institut Claudius Regaud
    Inventors: Christophe Cazaux, Jean-Sébastien Hoffmann, Jean-Christophe Bourdon, Alice Machado Da Silva, Henri Roche
  • SIGNATURE FOR THE DIAGNOSIS OF CANCER AGGRESSIVENESS AND GENETIC INSTABILITY
    Publication number: 20120021935
    Abstract: The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of said patient, comprising: a) measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in said patient cancer sample; b) calculating for said POLQ gene an expression level ratio of the expression level of POLQ to the expression of the said control gene in said patient cancer sample; c) comparing the said POLQ expression level ratio to a corresponding threshold value, and d) diagnosing cancer aggressiveness and genetic instability if the said POLQ expression level ratio is superior to a corresponding threshold values. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.
    Type: Application
    Filed: May 18, 2011
    Publication date: January 26, 2012
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT CLAUDIUS REGAUD, UNIVERSITE PAUL SABATIER TOULOUSE III
    Inventors: Christophe CAZAUX, Jean-Sébastien HOFFMANN, Jean-Christophe BOURDON, Alice MACHADO DA SILVA, Henri ROCHE