Patents by Inventor Henricus Petrus Martinus Maria Van Assouw

Henricus Petrus Martinus Maria Van Assouw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CARDIOVASCULAR SAFETY ASSAY
    Publication number: 20110076696
    Abstract: The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity of compounds during the development of new therapeutics and other agents.
    Type: Application
    Filed: August 20, 2010
    Publication date: March 31, 2011
    Applicant: JANSSEN PHARMACEUTICA, N.V.
    Inventors: GODELIEVE IRMA CHRISTINE MARIA HEYLEN, CORNELUS GERARDUS MARIA JANSSEN, JURZAK MIREK, HENRICUS PETRUS MARTINUS MARIA VAN ASSOUW
  • Cardiovascular safety assay
    Patent number: 7820453
    Abstract: The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity of compounds during the development of new therapeutics and other agents.
    Type: Grant
    Filed: November 6, 2006
    Date of Patent: October 26, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Godelieve Irma Christine Maria Heylen, Cornelus Gerardus Maria Janssen, Mirek Jurzak, Henricus Petrus Martinus Maria Van Assouw
  • Radiolabeled astemizole and method of making
    Patent number: 7541476
    Abstract: The present invention provides a radiolabeled astemizole of formula (III) and a process for preparing the radiolabeled astemizole of formula III.
    Type: Grant
    Filed: January 26, 2007
    Date of Patent: June 2, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Godelieve Irma Christine Maria Heylen, Cornelus Gerardus Maria Janssen, Jurzak Mirek, Henricus Petrus Martinus Maria Van Assouw
  • Cardiovascular safety assay
    Publication number: 20040161805
    Abstract: The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity of compounds during the development of new therapeutics and other agents.
    Type: Application
    Filed: January 13, 2004
    Publication date: August 19, 2004
    Inventors: Godelieve Irma Christine Heylen, Cornelus Gerardus Maria Janssen, Mirek Jurzak, Henricus Petrus Martinus Maria Van Assouw