Patents by Inventor Henriette Maria Aleida Adriaanse

Henriette Maria Aleida Adriaanse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for nucleic acid amplification using inosine triphosphates to partially replace guanosine triphosphates in the synthesis of multiple RNA copies
    Patent number: 5654142
    Abstract: The invention is an improved method for the amplification of nucleic acid, wherein ribonucleotides that weaken normal base pairing are introduced during amplification. Preferably, the ribonucleotides are inosine-triphosphate nucleotides which partly substitute guanine-triphosphate nucleotides normally present in the amplification reaction mixture. These ribonucleotides weaken normal base pairing and prevent the formation of secondary structures in the amplificate, thereby increasing the efficiency of amplification. Also, improved sensitivity results during detection of the amplified nucleic acid when the detection method comprises the hybridization of the amplified nucleic acid to a complementary sequence.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: August 5, 1997
    Assignee: Akzo Nobel N.V.
    Inventors: Tim Kievits, Peter Franklin Lens, Henriette Maria Aleida Adriaanse