Abstract: The present invention is directed to compounds of formula IIa These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.

Abstract: The present invention relates to a dental implant analog, an implant analog kit comprising the dental implant analog, the combination of a physical model of a set of a patient's teeth and the dental implant analog and a method of positioning a dental implant analog into a physical model of a set of a patient's teeth.

Abstract: Described is a composite material composed of an atomically thin (single layer) amorphous carbon disposed on top of a substrate (metal, glass, oxides) and methods of growing and differentiating stem cells.

Abstract: Described is a fuel cell comprising an electrode catalyst assembly, and a two-dimensional (2D) amorphous carbon, wherein the 2D amorphous carbon has a crystallinity (C)?0.8.

Abstract: A recording device comprising an overcoat layer, wherein the overcoat layer comprises an amorphous carbon overcoat layer having a crystallinity (C)?0.8.

Abstract: Described is a composite material composed of an atomically thin (single layer) amorphous carbon disposed on top of a substrate (metal, glass, oxides) and methods of growing and differentiating stem cells.

Abstract: The present invention relates to a dental implant analog, an implant analog kit comprising the dental implant analog, the combination of a physical model of a set of a patient's teeth and the dental implant analog and a method of positioning a dental implant analog into a physical model of a set of a patient's teeth.

Abstract: Apparatus (100) for cleaning the interior of a gas container (2) for pressurized gas; said apparatus comprising: —a rig (4) comprising container receiving means (6) for suspending said container; —an array (7) of elongate arms (8,8?,8?,8??), wherein said array (7) of elongate arms comprises: ii) an endoscope (14) comprising in its first end (10) image capturing means (16); and ii) a blasting arm (18) comprising in its first end (10?) a bias ling nozzle (19); wherein said apparatus comprises means (20,20?) for independently moving one or more of said elongate arms (8,8?,8?,8??), relative to said container receiving means (6), in such a way that the first end (10,10?, 10?,10??) of said one or more of said elongate arms can be inserted into the interior of a gas container (2), when said gas container is suspended in said rig.

Abstract: The invention relates to methods for directing differentiation of stem cells comprising graphene. In additional embodiments, the invention relates to methods for repairing and improving bone tissue functions comprising accelerating differentiation in stem cell growth by exposing stem cells to graphene and transplanting the graphene with the exposed stem cells in the tissue at the site of repair.

Abstract: A recording device comprising an overcoat layer, wherein the overcoat layer comprises an amorphous carbon overcoat layer having a crystallinity (C)?0.8.

Abstract: A version of the invention comprises a device for controlling or interfacing with a computer or other form of communicable machine based on the pyroelectric effect, and includes at least one optically- and infrared- (IR-) transparent graphene electrode.

Abstract: Variant antibodies having cysteine substitutions at selected positions in the Fc region can be conjugated via the thiol group of the substituted-in cysteine.

Abstract: Described is a fuel cell comprising an electrode catalyst assembly, and a two-dimensional (2D) amorphous carbon, wherein the 2D amorphous carbon has a crystallinity (C)?0.8.

Abstract: Described is a composite material composed of an atomically thin (single layer) amorphous carbon disposed on top of a substrate (metal, glass, oxides) and methods of growing and differentiating stem cells.

Abstract: A version of the invention comprises a device for controlling or interfacing with a computer or other form of communicable machine based on the pyroelectric effect, and includes at least one optically- and infrared- (IR-) transparent graphene electrode.

Abstract: The invention relates to a physical model of a person's teeth and to an analog configured to mutually snap engage upon insertion of the analog to a the desired depth into a hole in the physical model representative of an implant in the person's bone, with a peripheral or annular space between the analog and the model in the hole between the location of the snap engagement and a distal portion that together with the snap engagement define contact areas serving to keep the analog from sideways or turning movements within the hole.