Abstract: A multi-use drug delivery device for extended use, wherein the multi-use drug delivery device comprising a multi-use main portion (310) and a single-use flow conducting device (360) adapted for conducting drug to the subcutaneous tissue of a subject, wherein the change from a connected configuration to an unconnected configuration of the main portion and the flow conducting device is through the intermediate configuration. The intermediate configuration comprises an equalizing channel defining an equalizing flow path (304) different from an unintended flow path (303).

Abstract: A monitoring arrangement for an exercise device generates data items representing exercise activity by a user, performs a connection process for establishment of an end-to-end connection to a user device, broadcasts progress data that represents data items generated during the connection process, and sequentially transmits, on the end-to-end connection data items, generated after establishment of the end-to-end connection. The user device receives the progress data and presents, during the connection process, progress of the exercise activity based on the progress data. After establishment of the end-to-end connection, the user device presents progress of the exercise activity based on data items received on the end-to-end connection. The combination of broadcasting and sequential transmission obviates the need for the user to wait for the end-to-end connection before starting exercise activity.

Abstract: Drug delivery system comprising a dose setting member adapted to incrementally rotate in a first direction to set a dose, and incrementally rotate in an opposed second direction to reduce a set dose, the dose setting member having a rotational slack in each incremental rotational position. The system further comprises a rotary sensor adapted to detect the amount of rotation of the dose setting member during dose setting. Processor means is adapted to detect a first or second dose setting pattern when the final dose was set by rotating the setting member in the first respectively the second direction. When a first / second dose setting pattern is detected the detected amount of rotation is used to calculate a corrected amount of rotation using a first/ second algorithm compensating for a slack-induced error generated corresponding to the first/ second dose setting pattern.

Abstract: The disclosure relates generally to devices, systems and methods for measuring, transmitting, recording and displaying information relating to physical exercise and, more particularly, to a monitoring system for monitoring exercise machines comprising a lifting mechanism for selectively engaging one or more of the weights. A first aspect of the disclosure relates to an exercise machine monitoring system for monitoring exercise machines, where the exercise machines, comprise a plurality of stacked weights, the monitoring system comprises, for each of the exercise machines a repetition detector and an exercise machine identifier. The monitoring system further comprises an observer and a user device.

Abstract: A monitoring device performs a method of detecting a need for maintenance of an exercise machine comprising a time-of-flight, ToF, sensor. The method comprises obtaining a measurement signal from the ToF sensor at a predefined operating condition of the exercise machine. Based on the measurement signal, the method determines a measured distance between the ToF sensor and a reflective element in the exercise machine. The measured distance has been found to be responsive to accumulation of deposits on the ToF sensor and is thus evaluated by the method to detect a need for cleaning. The method thereby enables preventive maintenance.

Abstract: A drug delivery system comprises an indicator element and a sensor system. The indicator element is arranged to rotate relative to a reference component and corresponding to a reference axis and comprises a plurality of dipole magnets. The sensor system comprises a plurality of magnetometers arranged non-rotational relative to the reference component and adapted to determine continuous magnetic field values from the plurality of dipole magnets, as well as processor means configured to determine on the basis of measured values from the plurality of magnetometers a rotational position and/or a rotational movement of the indicator element.

Abstract: A drug delivery system comprises an indicator element and a sensor system. The indicator element is arranged to rotate relative to a reference component and corresponding to a reference axis and comprises a plurality of dipole magnets. The sensor system comprises a plurality of magnetometers arranged non-rotational relative to the reference component and adapted to determine continuous magnetic field values from the plurality of dipole magnets, as well as processor means configured to determine on the basis of measured values from the plurality of magnetometers a rotational position and/or a rotational movement of the indicator element.

Abstract: Systems and methods are provided for optimizing short acting insulin medicament dosage timing relative to a meal event for a subject. Glucose measurements of the subject over a time course and the timing of the measurements are obtained. Meal events in the time course and information regarding when dosages were injected into the subject relative to the meal events is obtained. Bins, each for a different time range for when a dosage is injected relative to a meal event, are constructed. Each bin is assigned glucose measurements in one or more periods within the time course in which the subject injected the dosage within the time range associated with the bin. A glycaemic risk measure is determined for each bin with the assigned measurements and used to identify an optimal relative time range for the subject. This is communicated to a health care practitioner or to the subject.

Abstract: The invention relates to an injection device for ejecting a predetermined plurality of fixed doses. The doses are expelled by moving a needle shield (30) in the proximal direction which releases a pre-strained torsion spring (115) to eject one of the predetermined doses at the time. The injection device is further provided with a number of integrated needle assemblies (70) which one at the time are brought to an injection position. The needle change mechanism (80,90) operating the needle assemblies is controlled by rotation of the needle shield which is rotatable between a locked and an unlocked position.

Abstract: The present invention provides a needle unit (10) for use with a pen injection device, wherein the needle unit (10) comprises a needle shield (50) and an axially movable needle hub (25).

Abstract: Systems and methods for evaluating insulin medicament dosage regimen adherence by a subject are provided. A description of metabolic events the subject engaged in is obtained. Each event comprises a timestamp and a classification that is one of insulin regimen adherent and insulin regimen nonadherent. Events are binned into consecutive time windows on the basis of time to obtain a plurality of subsets. Adherence values are computed. Each adherence value is for a subset and is computed by dividing the insulin regimen adherent events by the total number of events in the subset. Adherence values are combined into a composite value by a process that comprises downweighting a first adherence value, representing a first time window, with respect to a second adherence value, representing a second time window, when the first time window occurs in time before the second time window. The composite value is communicated as a single representation.

Abstract: A housing for a Time-of-Flight (ToF) range meter includes a wall structure defining a first optical beam path to an emitter of the ToF range meter, and a second optical beam path to a detector of the ToF range meter, and a transmissive optical diffusor configured to cover the beam path to at least one of said emitter and said detector. The housing may be connected to a ToF range meter into a ToF ranging device. Such a ToF ranging device where the ToF ranging device is directed to measure a distance to a reflector member to determine a distance which correlates to the weight of the selectively engaged weights.

Abstract: A benchmarking approach is employed that compares advice output from one or more alternative treatment guidance algorithms with a current actual treatment in terms of treatment outcomes. Treatment outcome for the current strategy is reflected in an actual BG outcome or profiled. Treatment outcome for an alternative algorithm-generated dose advice is based on a patient-specific model. The two sets of outcomes can be compared directly or using performance scores as a weighted combination that penalises or rewards certain outcomes. A statistical test may be applied to the accumulated results (paired outcomes or scores) to determine whether the algorithm is superior to the user's current dosing strategy, or alternative strategies.

Abstract: A subject is prescribed short and long acting insulin medicament regimens. When a qualified fasting event occurs, the basal insulin sensitivity estimate of the subject is updated using (i) an expected fasting blood glucose level based upon the long acting insulin medicament dosing specified by the long acting regimen during the fasting event, (ii) glucose measurements contemporaneous with the fasting event and (iii) a prior insulin sensitivity factor. A basal insulin sensitivity factor curve is calculated from the updated basal insulin sensitivity estimate. A bolus insulin sensitivity estimate of the subject is updated upon occurrence of a correction bolus with a short acting insulin medicament using (i) an expected blood glucose level based upon the correction bolus, (ii) glucose measurements after occurrence of the correction bolus, and (iii) a prior insulin sensitivity factor. A bolus insulin sensitivity factor curve is calculated from the updated bolus insulin sensitivity estimate.

Abstract: Add-on device for a drug delivery pen device, comprising a drive member adapted for coupling to a dose dial member of the pen device, a dial member adapted to rotate the drive member in first and second directions to set/adjust a pen dose, a release member axially moveable to actuate a pen device release button, a linear-to-rotational converter mechanism adapted to convert axial movement of the release member to rotational movement of the drive member in a first direction, whereby, when the add-on device is mounted on the drug delivery pen device: the dose dial member of the pen device is biased in the first direction by the drive member thereby taking up rotational slack in the pen device.

Abstract: The present invention provides a needle unit (10) for use with a pen injection device, wherein the needle unit (10) comprises a needle shield (50) and an axially movable needle hub (25).

Abstract: the present invention provides a needle system comprising a needle assembly (1, 100, 200, 300) and a drug cartridge (30, 130, 230, 330), the needle assembly (1, 100, 200, 300) comprising a needle hub member (4.1, 104.1, 204.1, 304.1) in which an injection needle (15, 115, 215, 315) is fixedly mounted such that a front needle portion (15f, 115f, 215f, 315f) extends in a distal direction therefrom and a rear needle portion (15r, 115r, 215r, 315r) extends in a proximal direction therefrom, and a skirt member (4.2, 104.2, 204.2, 304.2) extending proximally from the needle hub member (4.1, 104.1, 204.1, 304.1) and defining a skirt cavity (4.9, 104.9, 204.9, 304.9) accommodating the rear needle portion (15r, 115r, 215r, 315r), the skirt cavity (4.9, 104.9, 204.9, 304.

Abstract: The present invention provides a needle assembly (1) for a drug delivery device, comprising a needle hub (25) in which a needle (15) is fixedly mounted, the needle (15) extending along a reference axis and comprising a needle body with a lumen and a distal needle end portion adapted for insertion through a skin layer, a needle shield (12) axially displaceable relative to the needle hub (25) between an extended position in which the distal needle end portion is covered and a retracted position in which the distal needle end portion is exposed, the nee-dle shield (12) being biased towards the extended position, and an elastomeric plug member (10) fitted tightly around a portion of the needle (15), the plug member (10) comprising a self-sealing front section (10.

Abstract: Systems and methods are provided for adjusting a standing insulin medicament dosage regimen for a subject. Fasting events are identified using autonomous timestamped glucose measurements of the subject in a first data set. A second data set, from one or more insulin pens used to apply the standing regimen, comprises records, each record comprising a timestamped event specifying an amount of injected insulin medicament. Each fasting event is characterized as adherent or nonadherent. A fasting event is adherent when the second data set includes one or more records that temporally and quantitatively establish adherence with the standing regimen during the fasting event. Conversely, a fasting event is nonadherent when the second data set fails to temporally and quantitatively establish adherence with the standing regimen.

Abstract: Systems and methods are provided for adjusting a basal/bolus ratio in a standing insulin regimen for a subject that comprises daily amounts of basal and bolus insulin medicaments that define an initial basal/bolus ratio. A data set comprising glucose measurements of the subject with a respective timestamp for each such measurement over a time course is obtained. One or more fasting events are identified in the time course. A temporal glucose gradient is computed for each fasting event using the glucose measurements in the data set within the fasting event time period. Fasting event glucose gradients are used to determine whether to recommend adjustment to the basal/bolus ratio for the subject without change to the daily total insulin medicament. The recommended adjustment to the basal/bolus ratio is communicated when the determination is made to make the recommended adjustment to the basal/bolus ratio for the subject.